KIFA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIFA3_MOUSE
• UniProt AC: P70188
• Protein Name: Kinesin-associated protein 3
• Gene Name: Kifap3
• Organism: Mus musculus (Mouse).
• Sequence Length: 793
• Protein Description: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex..
• Protein Sequence: MQGEDARYLKRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLSEVEQLLYYLQNRRDSLPGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDLENQTLRKDYDKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKLKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISSDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPFLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQLDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLITSEGAISPDFFNDFHLQNGDVVGQHAFPGSLGMDGFGQPLGILGRPATAYGFRPDEPYYYSFGSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MQGEDARYLKRKVKG CCCHHHHHHHHHCCC	20.49	29514104
60	Phosphorylation	QKIIRLKSLNANTDI HHHHHHHHCCCCCCH	31.29	25521595
65	Phosphorylation	LKSLNANTDITSLAR HHHCCCCCCHHHHHH	26.77	28833060
84	Phosphorylation	ECKLIHPSKLSEVEQ HCCCCCHHHCHHHHH	31.87	30387612
94	Phosphorylation	SEVEQLLYYLQNRRD HHHHHHHHHHHHCHH	15.66	23984901
95	Phosphorylation	EVEQLLYYLQNRRDS HHHHHHHHHHHCHHC	11.20	23984901
102	Phosphorylation	YLQNRRDSLPGKEKK HHHHCHHCCCCHHHC	34.35	25521595
256	Phosphorylation	DEDLENQTLRKDYDK CHHHHHCHHHHHHHH	39.86	29176673
411	Phosphorylation	MCVLYHISMDDRFKS HHHHHHCCCCHHHHH	11.66	28285833
437	Phosphorylation	MKMLFECSDERIDLE HHHHHHCCCCCCCHH	35.00	-
477	Ubiquitination	MLMKRALKLKDPLLM HHHHHHHHCCCHHHH	53.13	22790023
630	Ubiquitination	ATRDVIIKETQAPAY HCHHHHEECCCCCHH	43.51	-
786	Phosphorylation	GFRPDEPYYYSFGSR CCCCCCCCCCCCCCC	17.00	22817900
787	Phosphorylation	FRPDEPYYYSFGSR- CCCCCCCCCCCCCC-	11.89	22817900
788	Phosphorylation	RPDEPYYYSFGSR-- CCCCCCCCCCCCC--	7.53	18563927

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIFA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIFA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIFA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF3B_MOUSE	Kif3b	physical	15834408
CTNB1_MOUSE	Ctnnb1	physical	15834408
CADH2_MOUSE	Cdh2	physical	15834408
CTND1_MOUSE	Ctnnd1	physical	15834408
ZN821_MOUSE	Zfp821	physical	23954693

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.