SYYC_MOUSE - dbPTM
SYYC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYYC_MOUSE
UniProt AC Q91WQ3
Protein Name Tyrosine--tRNA ligase, cytoplasmic
Gene Name Yars
Organism Mus musculus (Mouse).
Sequence Length 528
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)..
Protein Sequence MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTVYLELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPPAKGPAKNSEPEEVIPSRLDIRVGKILSVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSRQVEPLDPPAGSAPGERVFVQGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGFVSCKSLKGGNIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MGDAPSPE
-------CCCCCCHH		11.20-
2Acetylation------MGDAPSPEE
------CCCCCCHHH		39.52-
6Phosphorylation--MGDAPSPEEKLHL
--CCCCCCHHHHHHH		46.8225293948
47AcetylationWGTATTGKPHVAYFV
EECCCCCCCEEEEEE		29.8322826441
58AcetylationAYFVPMSKIADFLKA
EEEEEHHHHHHHHHH		35.3422826441
114AcetylationSIGVPLEKLKFIKGT
HCCCCHHHCCCCCCC		65.7422826441
119AcetylationLEKLKFIKGTDYQLS
HHHCCCCCCCCCCCC		59.9122826441
121PhosphorylationKLKFIKGTDYQLSKE
HCCCCCCCCCCCCEE		26.9121454597
146AcetylationVVTQHDAKKAGAEVV
CCCHHHHHHHCHHHH		49.5723954790
146MalonylationVVTQHDAKKAGAEVV
CCCHHHHHHHCHHHH		49.5726320211
147MalonylationVTQHDAKKAGAEVVK
CCHHHHHHHCHHHHH		54.4926320211
190MalonylationFGGVDQRKIFTFAEK
CCCCCHHHHHHHHHH		36.2226320211
197UbiquitinationKIFTFAEKYLPALGY
HHHHHHHHHHHHCCC		48.97-
197AcetylationKIFTFAEKYLPALGY
HHHHHHHHHHHHCCC		48.9723954790
205PhosphorylationYLPALGYSKRVHLMN
HHHHCCCCCCEECCC		16.5225338131
206UbiquitinationLPALGYSKRVHLMNP
HHHCCCCCCEECCCC		50.37-
206AcetylationLPALGYSKRVHLMNP
HHHCCCCCCEECCCC		50.37-
272AcetylationKHVLFPLKSEFVILR
HHHHHCCCCCEEEEE		48.4522826441
334MalonylationKFNTPALKKLASAAY
HCCCHHHHHHHHCCC		48.0926320211
334UbiquitinationKFNTPALKKLASAAY
HCCCHHHHHHHHCCC		48.09-
335MalonylationFNTPALKKLASAAYP
CCCHHHHHHHHCCCC		50.5726320211
335UbiquitinationFNTPALKKLASAAYP
CCCHHHHHHHHCCCC		50.57-
338PhosphorylationPALKKLASAAYPDPS
HHHHHHHHCCCCCHH		24.7029514104
356MalonylationPPAKGPAKNSEPEEV
CCCCCCCCCCCCCCC		65.2326320211
358PhosphorylationAKGPAKNSEPEEVIP
CCCCCCCCCCCCCCC		54.5525338131
386PhosphorylationEKHPDADSLYVEKID
ECCCCCCCEEEEEEC		24.26-
412AcetylationGLVQFVPKEELQDRL
EEEEECCHHHHHHCE		59.5223236377
427AcetylationVVVLCNLKPQKMRGV
EEEEECCCCHHCCCC		31.2622826441
442GlutathionylationDSQGMLLCASVEGVS
CCCCCEEEEEECCCC		2.0324333276
474AcetylationVFVQGYEKGQPDEEL
EEECCCCCCCCCCCC		55.1323954790
474MalonylationVFVQGYEKGQPDEEL
EEECCCCCCCCCCCC		55.1326320211
482AcetylationGQPDEELKPKKKVFE
CCCCCCCCCCHHHHH		59.0623954790
490AcetylationPKKKVFEKLQADFKI
CCHHHHHHHHHHHCC		34.14-
490MalonylationPKKKVFEKLQADFKI
CCHHHHHHHHHHHCC		34.1426320211
513UbiquitinationKQTNFMTKLGFVSCK
HHCCHHHHHCCEECC		34.52-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYYC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYYC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYYC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYYC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYYC_MOUSE

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Related Literatures of Post-Translational Modification

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