CSCL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSCL1_MOUSE
• UniProt AC: Q91YT8
• Protein Name: CSC1-like protein 1
• Gene Name: Tmem63a
• Organism: Mus musculus (Mouse).
• Sequence Length: 804
• Subcellular Localization: Lysosome membrane; Multi-pass membrane protein.
• Protein Description: Acts as an osmosensitive calcium-permeable cation channel..
• Protein Sequence: MTSSPFLDPWPSKAVFVRERLGLGERPNDSYCYNSAKNSTVLQGVTFGGIPTVLLLDVSCFLFLILVFSIIRRRFWDYGRIALVSEAGSEARFQRLSSSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVISFLSLCVILPVNLSGDLLGKDPYSFGRTTIANLQTDNDLLWLHTVFSVIYLFLTVGFMWHHTRSIRYKEESLVRQTLFITGLPREARKETVESHFRDAYPTCEVVDVQLCYSVAKLIYLCKERKKTEKSLTYYTNLQAKTGRRTLINPKPCGQFCCCEVQGCEREDAISYYTRMNDSLLERITAEESRVQDQPLGMAFVTFREKSMATYILKDFNACKCQGLRCKGEPQPSSYSRELCVSKWTVTFASYPEDICWKNLSIQGVRWWLQWLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPSIVYYSTLLESHWTRSGENRIMVSKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSETSIRLECVFLPDQGAFFVNYVIASAFIGSGMELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLFFFSFLRLGLTAPATLFTFLVVLLTILACLLYTCFGCFKHLSPWNYKTEESASDKGSEAEAHVPPPFTPYVPRILNGLASERTALSPQQQQTYGAIRNISGTLPGQPVAQDPSGTAAYAYQES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	YGRIALVSEAGSEAR HHHEEEEECCCHHHH		28066266
89	Phosphorylation	ALVSEAGSEARFQRL EEEECCCHHHHHHHH		28066266
97	Phosphorylation	EARFQRLSSSSSGQQ HHHHHHHHCCCCCCH		21189417
98	Phosphorylation	ARFQRLSSSSSGQQD HHHHHHHCCCCCCHH		23649490
99	Phosphorylation	RFQRLSSSSSGQQDF HHHHHHCCCCCCHHH		23649490
101	Phosphorylation	QRLSSSSSGQQDFEN HHHHCCCCCCHHHCH		23649490
220	Ubiquitination	HTRSIRYKEESLVRQ HHCCCCCCHHHHHHH		27667366
278	Phosphorylation	LCKERKKTEKSLTYY HHHHHCCCCCCHHHE		28576409
303	S-palmitoylation	TLINPKPCGQFCCCE CCCCCCCCCCEEEEE		28680068
307	S-palmitoylation	PKPCGQFCCCEVQGC CCCCCCEEEEECCCC		28680068
308	S-palmitoylation	KPCGQFCCCEVQGCE CCCCCEEEEECCCCC		28680068
309	S-palmitoylation	PCGQFCCCEVQGCER CCCCEEEEECCCCCH		28680068
314	S-palmitoylation	CCCEVQGCEREDAIS EEEECCCCCHHHHHH		28680068
395	Phosphorylation	ELCVSKWTVTFASYP CEEEEEEEEEEECCC		24719451
729	Phosphorylation	LSPWNYKTEESASDK CCCCCCCCCCCCCCC		19060867
732	Phosphorylation	WNYKTEESASDKGSE CCCCCCCCCCCCCCC		29472430
734	Phosphorylation	YKTEESASDKGSEAE CCCCCCCCCCCCCCH		19060867
736	Ubiquitination	TEESASDKGSEAEAH CCCCCCCCCCCCHHC		22790023
738	Phosphorylation	ESASDKGSEAEAHVP CCCCCCCCCCHHCCC		22817900
764	Phosphorylation	NGLASERTALSPQQQ HHHHCCCCCCCHHHH		26239621
767	Phosphorylation	ASERTALSPQQQQTY HCCCCCCCHHHHHHH		26239621
773	Phosphorylation	LSPQQQQTYGAIRNI CCHHHHHHHHHHHHC		28833060
774	Phosphorylation	SPQQQQTYGAIRNIS CHHHHHHHHHHHHCC		28833060
781	Phosphorylation	YGAIRNISGTLPGQP HHHHHHCCCCCCCCC		25338131
783	Phosphorylation	AIRNISGTLPGQPVA HHHHCCCCCCCCCCC		25338131
794	Phosphorylation	QPVAQDPSGTAAYAY CCCCCCCCCCEEEEC		25338131
804	Phosphorylation	AAYAYQES------- EEEECCCC-------		25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSCL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSCL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSCL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSCL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.