UniProt ID | TR150_MOUSE | |
---|---|---|
UniProt AC | Q569Z6 | |
Protein Name | Thyroid hormone receptor-associated protein 3 | |
Gene Name | Thrap3 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 951 | |
Subcellular Localization | Nucleus . Nucleus, nucleoplasm . Nucleus speckle . | |
Protein Description | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes. [PubMed: 24043798] | |
Protein Sequence | MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSVSRSRKRRLSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRGGYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSTKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDIKGSESSKPWPDATTYGAGSASRASVSDLSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSNASQMGSSMSGGAGYQSGAHQGQFDHGSGSLSPSKKSPVGKSPPATGSAYGSSQKEESAASGGAAYSKRYLEEQKTENGKDKEQKQTNADKEKLKEKGGFSDADVKMKSDPFAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEELDEHDKDKSKGRKEPEFDDEPKFMSKVIAGASKNQEEEKSGKWESLHTGKEKQRKAEEMEDEPFTERSRKEERGGSKRSESGHRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGSKGDFSSGKSSFSITREAQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGNEQEAAKNKKSPEIHRRIDISPSTFRKHGLTHEELKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRESVDSRDSSHSRERSTEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYPEEAEEREESTSGFDKSRLGTKDFVGPNERGGRARGTFQFRARGRGWGRGNYSGNNNNNSNNDFQKRSREEEWDPEYTPKSKKYYLHDDREGEGSDKWMGRGRGRGAFPRGRGRFMFRKSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDSLQPSAE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MSKTNKSKS ------CCCCCCCCC | 48.46 | - | |
13 | Phosphorylation | KSKSGSRSSRSRSAS CCCCCCCCHHCHHHH | 31.62 | 20531401 | |
14 | Phosphorylation | SKSGSRSSRSRSASR CCCCCCCHHCHHHHH | 32.91 | 19854140 | |
16 | Phosphorylation | SGSRSSRSRSASRSR CCCCCHHCHHHHHHH | 32.32 | 20531401 | |
17 | Methylation | GSRSSRSRSASRSRS CCCCHHCHHHHHHHH | 34.82 | - | |
38 | Phosphorylation | RSRSRSVSRSRKRRL HHHHHHHCHHHHHHH | 26.28 | 25890499 | |
46 | Phosphorylation | RSRKRRLSSRSRSRS HHHHHHHHHHHHCCC | 23.15 | 23737553 | |
47 | Phosphorylation | SRKRRLSSRSRSRSY HHHHHHHHHHHCCCC | 38.58 | 23737553 | |
49 | Phosphorylation | KRRLSSRSRSRSYSP HHHHHHHHHCCCCCC | 36.23 | 25159016 | |
51 | Phosphorylation | RLSSRSRSRSYSPAH HHHHHHHCCCCCCCC | 27.16 | 27742792 | |
53 | Phosphorylation | SSRSRSRSYSPAHNR HHHHHCCCCCCCCCC | 31.07 | 25521595 | |
54 | Phosphorylation | SRSRSRSYSPAHNRE HHHHCCCCCCCCCCC | 19.98 | 23684622 | |
55 | Phosphorylation | RSRSRSYSPAHNRER HHHCCCCCCCCCCCC | 19.50 | 25521595 | |
66 | Asymmetric dimethylarginine | NRERNHPRVYQNRDF CCCCCCCCCCCCCCC | 32.02 | - | |
66 | Methylation | NRERNHPRVYQNRDF CCCCCCCCCCCCCCC | 32.02 | 54560283 | |
71 | Dimethylation | HPRVYQNRDFRGHNR CCCCCCCCCCCCCCC | 28.99 | - | |
71 | Methylation | HPRVYQNRDFRGHNR CCCCCCCCCCCCCCC | 28.99 | 54560307 | |
91 | Dimethylation | YYFRGRNRGFYPWGQ CEECCCCCCCCCCCC | 34.93 | - | |
91 | Methylation | YYFRGRNRGFYPWGQ CEECCCCCCCCCCCC | 34.93 | 54560291 | |
101 | Asymmetric dimethylarginine | YPWGQYNRGGYGNYR CCCCCCCCCCCCCCC | 34.67 | - | |
101 | Methylation | YPWGQYNRGGYGNYR CCCCCCCCCCCCCCC | 34.67 | 24129315 | |
108 | Asymmetric dimethylarginine | RGGYGNYRSNWQNYR CCCCCCCCCCHHHHH | 27.75 | - | |
108 | Methylation | RGGYGNYRSNWQNYR CCCCCCCCCCHHHHH | 27.75 | 24129315 | |
114 | Phosphorylation | YRSNWQNYRQAYSPR CCCCHHHHHHHCCCC | 6.76 | 23984901 | |
118 | Phosphorylation | WQNYRQAYSPRRGRS HHHHHHHCCCCCCCC | 15.74 | 25367039 | |
119 | Phosphorylation | QNYRQAYSPRRGRSR HHHHHHCCCCCCCCC | 18.23 | 27087446 | |
125 | Phosphorylation | YSPRRGRSRSRSPKR CCCCCCCCCCCCCCC | 37.11 | 19367708 | |
127 | Phosphorylation | PRRGRSRSRSPKRRS CCCCCCCCCCCCCCC | 38.05 | 19367708 | |
129 | Phosphorylation | RGRSRSRSPKRRSPS CCCCCCCCCCCCCCC | 35.70 | 23384938 | |
134 | Phosphorylation | SRSPKRRSPSPRSRS CCCCCCCCCCCCCCC | 33.49 | 23684622 | |
136 | Phosphorylation | SPKRRSPSPRSRSHS CCCCCCCCCCCCCCC | 33.90 | 23684622 | |
139 | Phosphorylation | RRSPSPRSRSHSRNS CCCCCCCCCCCCCCC | 41.33 | 29899451 | |
167 | Phosphorylation | SRSSSNHSRVESSKR CCCHHHHHHHHHHHC | 42.12 | 20139300 | |
171 | Phosphorylation | SNHSRVESSKRKSTK HHHHHHHHHHCCCCC | 38.00 | 20139300 | |
172 | Phosphorylation | NHSRVESSKRKSTKE HHHHHHHHHCCCCCC | 23.99 | 20139300 | |
182 | Phosphorylation | KSTKEKKSSSKDSRP CCCCCCCCCCCCCCH | 51.41 | 25521595 | |
183 | Phosphorylation | STKEKKSSSKDSRPS CCCCCCCCCCCCCHH | 50.73 | 24453211 | |
184 | Phosphorylation | TKEKKSSSKDSRPSQ CCCCCCCCCCCCHHH | 47.80 | 25521595 | |
187 | Phosphorylation | KKSSSKDSRPSQAAG CCCCCCCCCHHHHCC | 50.23 | 25521595 | |
190 | Phosphorylation | SSKDSRPSQAAGDNQ CCCCCCHHHHCCCCC | 31.20 | 25521595 | |
205 | Phosphorylation | GDEAKEQTFSGGTSQ CHHHHHHHCCCCCCC | 22.36 | 25159016 | |
207 | Phosphorylation | EAKEQTFSGGTSQDI HHHHHHCCCCCCCCC | 39.43 | 25521595 | |
210 | Phosphorylation | EQTFSGGTSQDIKGS HHHCCCCCCCCCCCC | 27.09 | 23684622 | |
211 | Phosphorylation | QTFSGGTSQDIKGSE HHCCCCCCCCCCCCC | 29.18 | 25521595 | |
217 | Phosphorylation | TSQDIKGSESSKPWP CCCCCCCCCCCCCCC | 29.33 | 25367039 | |
219 | Phosphorylation | QDIKGSESSKPWPDA CCCCCCCCCCCCCCC | 45.41 | 25367039 | |
220 | Phosphorylation | DIKGSESSKPWPDAT CCCCCCCCCCCCCCC | 38.39 | 25367039 | |
221 | Acetylation | IKGSESSKPWPDATT CCCCCCCCCCCCCCC | 61.45 | 22826441 | |
227 | Phosphorylation | SKPWPDATTYGAGSA CCCCCCCCCCCCCCC | 28.12 | 25367039 | |
228 | Phosphorylation | KPWPDATTYGAGSAS CCCCCCCCCCCCCCC | 22.98 | 26745281 | |
229 | Phosphorylation | PWPDATTYGAGSASR CCCCCCCCCCCCCCC | 10.71 | 23984901 | |
233 | Phosphorylation | ATTYGAGSASRASVS CCCCCCCCCCCCCHH | 23.65 | 23684622 | |
235 | Phosphorylation | TYGAGSASRASVSDL CCCCCCCCCCCHHHC | 30.03 | 26745281 | |
238 | Phosphorylation | AGSASRASVSDLSPR CCCCCCCCHHHCCHH | 22.50 | 24925903 | |
240 | Phosphorylation | SASRASVSDLSPRER CCCCCCHHHCCHHHC | 30.27 | 24925903 | |
243 | Phosphorylation | RASVSDLSPRERSPA CCCHHHCCHHHCCHH | 27.23 | 18388127 | |
248 | Phosphorylation | DLSPRERSPALKSPL HCCHHHCCHHHCCCC | 15.12 | 18388127 | |
252 | Acetylation | RERSPALKSPLQSVV HHCCHHHCCCCEEEE | 52.73 | 22826441 | |
252 | Methylation | RERSPALKSPLQSVV HHCCHHHCCCCEEEE | 52.73 | - | |
253 | Phosphorylation | ERSPALKSPLQSVVV HCCHHHCCCCEEEEE | 31.52 | 18388127 | |
257 | Phosphorylation | ALKSPLQSVVVRRRS HHCCCCEEEEEECCC | 25.27 | 24925903 | |
264 | Phosphorylation | SVVVRRRSPRPSPVP EEEEECCCCCCCCCC | 24.37 | 26824392 | |
268 | Phosphorylation | RRRSPRPSPVPKPSP ECCCCCCCCCCCCCC | 39.55 | 27742792 | |
274 | Phosphorylation | PSPVPKPSPPLSNAS CCCCCCCCCCCCCHH | 45.32 | 26370283 | |
278 | Phosphorylation | PKPSPPLSNASQMGS CCCCCCCCCHHHCCC | 35.80 | 25293948 | |
281 | Phosphorylation | SPPLSNASQMGSSMS CCCCCCHHHCCCCCC | 25.58 | 26160508 | |
285 | Phosphorylation | SNASQMGSSMSGGAG CCHHHCCCCCCCCCC | 19.95 | 26160508 | |
286 | Phosphorylation | NASQMGSSMSGGAGY CHHHCCCCCCCCCCC | 15.96 | 26160508 | |
288 | Phosphorylation | SQMGSSMSGGAGYQS HHCCCCCCCCCCCCC | 35.70 | 26160508 | |
293 | Phosphorylation | SMSGGAGYQSGAHQG CCCCCCCCCCCCCCC | 10.04 | 26160508 | |
295 | Phosphorylation | SGGAGYQSGAHQGQF CCCCCCCCCCCCCCC | 29.48 | 26160508 | |
306 | Phosphorylation | QGQFDHGSGSLSPSK CCCCCCCCCCCCCCC | 23.07 | 26160508 | |
308 | Phosphorylation | QFDHGSGSLSPSKKS CCCCCCCCCCCCCCC | 27.63 | 25266776 | |
310 | Phosphorylation | DHGSGSLSPSKKSPV CCCCCCCCCCCCCCC | 28.91 | 26160508 | |
312 | Phosphorylation | GSGSLSPSKKSPVGK CCCCCCCCCCCCCCC | 49.71 | 26160508 | |
315 | Phosphorylation | SLSPSKKSPVGKSPP CCCCCCCCCCCCCCC | 28.67 | 25521595 | |
320 | Phosphorylation | KKSPVGKSPPATGSA CCCCCCCCCCCCCCC | 30.13 | 27087446 | |
324 | Phosphorylation | VGKSPPATGSAYGSS CCCCCCCCCCCCCCC | 37.13 | 24925903 | |
326 | Phosphorylation | KSPPATGSAYGSSQK CCCCCCCCCCCCCHH | 17.60 | 24925903 | |
328 | Phosphorylation | PPATGSAYGSSQKEE CCCCCCCCCCCHHHH | 21.16 | 24925903 | |
330 | Phosphorylation | ATGSAYGSSQKEESA CCCCCCCCCHHHHHH | 19.54 | 24925903 | |
331 | Phosphorylation | TGSAYGSSQKEESAA CCCCCCCCHHHHHHH | 40.69 | 24925903 | |
336 | Phosphorylation | GSSQKEESAASGGAA CCCHHHHHHHCCCHH | 30.17 | 25619855 | |
339 | Phosphorylation | QKEESAASGGAAYSK HHHHHHHCCCHHHHH | 37.16 | 25619855 | |
344 | Phosphorylation | AASGGAAYSKRYLEE HHCCCHHHHHHHHHH | 17.75 | 25619855 | |
345 | Phosphorylation | ASGGAAYSKRYLEEQ HCCCHHHHHHHHHHH | 13.11 | 25619855 | |
346 | Acetylation | SGGAAYSKRYLEEQK CCCHHHHHHHHHHHC | 32.17 | 23806337 | |
346 | Malonylation | SGGAAYSKRYLEEQK CCCHHHHHHHHHHHC | 32.17 | 26320211 | |
353 | Acetylation | KRYLEEQKTENGKDK HHHHHHHCCCCCCCH | 62.17 | 7615345 | |
354 | Phosphorylation | RYLEEQKTENGKDKE HHHHHHCCCCCCCHH | 34.08 | 21659604 | |
358 | Acetylation | EQKTENGKDKEQKQT HHCCCCCCCHHHHHH | 76.76 | 7615357 | |
369 | Acetylation | QKQTNADKEKLKEKG HHHHHHHHHHHHHHC | 55.10 | 7615369 | |
375 | Ubiquitination | DKEKLKEKGGFSDAD HHHHHHHHCCCCHHH | 63.85 | 27667366 | |
379 | Phosphorylation | LKEKGGFSDADVKMK HHHHCCCCHHHCCCC | 34.85 | 27087446 | |
386 | Acetylation | SDADVKMKSDPFAPK CHHHCCCCCCCCCCC | 46.09 | 23806337 | |
387 | Phosphorylation | DADVKMKSDPFAPKT HHHCCCCCCCCCCCC | 47.20 | 27717184 | |
394 | Phosphorylation | SDPFAPKTDSEKPFR CCCCCCCCCCCCCCC | 43.64 | 23429704 | |
396 | Phosphorylation | PFAPKTDSEKPFRGS CCCCCCCCCCCCCCC | 53.39 | 23429704 | |
398 | Acetylation | APKTDSEKPFRGSQS CCCCCCCCCCCCCCC | 54.10 | 23806337 | |
403 | Phosphorylation | SEKPFRGSQSPKRYK CCCCCCCCCCCCCCC | 24.19 | 18388127 | |
405 | Phosphorylation | KPFRGSQSPKRYKLR CCCCCCCCCCCCCCH | 33.80 | 18388127 | |
417 | Acetylation | KLRDDFEKKMADFHK CCHHHHHHHHHHHHH | 48.09 | 22826441 | |
432 | Acetylation | EELDEHDKDKSKGRK HHHHHHCHHHCCCCC | 69.80 | 23806337 | |
452 | Acetylation | DEPKFMSKVIAGASK CCHHHHHHHHHHCCC | 26.35 | 23806337 | |
466 | Phosphorylation | KNQEEEKSGKWESLH CCHHHHHHCCCHHCC | 49.21 | 18779572 | |
468 | Acetylation | QEEEKSGKWESLHTG HHHHHHCCCHHCCCH | 55.68 | 23806337 | |
471 | Phosphorylation | EKSGKWESLHTGKEK HHHCCCHHCCCHHHH | 25.08 | 29514104 | |
476 | Acetylation | WESLHTGKEKQRKAE CHHCCCHHHHHHHHH | 63.99 | 23806337 | |
502 | Phosphorylation | RKEERGGSKRSESGH HHHHCCCCCCCCCCC | 27.93 | 27717184 | |
505 | Phosphorylation | ERGGSKRSESGHRGF HCCCCCCCCCCCCCC | 39.59 | 26745281 | |
507 | Phosphorylation | GGSKRSESGHRGFVP CCCCCCCCCCCCCCC | 40.94 | 26745281 | |
516 | Acetylation | HRGFVPEKNFRVTAY CCCCCCCCCEEEEEH | 56.14 | 23806337 | |
524 | Acetylation | NFRVTAYKAVQEKSS CEEEEEHHHHHHHCC | 39.35 | 23806337 | |
524 | Malonylation | NFRVTAYKAVQEKSS CEEEEEHHHHHHHCC | 39.35 | 26320211 | |
530 | Phosphorylation | YKAVQEKSSSPPPRK HHHHHHHCCCCCCCC | 34.98 | 27087446 | |
531 | Phosphorylation | KAVQEKSSSPPPRKT HHHHHHCCCCCCCCC | 58.91 | 25263469 | |
532 | Phosphorylation | AVQEKSSSPPPRKTS HHHHHCCCCCCCCCC | 48.82 | 27087446 | |
538 | Phosphorylation | SSPPPRKTSESRDKL CCCCCCCCCHHHHHH | 38.72 | 23375375 | |
541 | Phosphorylation | PPRKTSESRDKLGSK CCCCCCHHHHHHCCC | 45.61 | 23375375 | |
547 | Phosphorylation | ESRDKLGSKGDFSSG HHHHHHCCCCCCCCC | 43.85 | 27681418 | |
548 | Malonylation | SRDKLGSKGDFSSGK HHHHHCCCCCCCCCC | 61.78 | 26320211 | |
552 | Phosphorylation | LGSKGDFSSGKSSFS HCCCCCCCCCCCCEE | 42.81 | 27149854 | |
553 | Phosphorylation | GSKGDFSSGKSSFSI CCCCCCCCCCCCEEE | 50.67 | 29899451 | |
555 | Acetylation | KGDFSSGKSSFSITR CCCCCCCCCCEEEEE | 44.89 | 23806337 | |
555 | Malonylation | KGDFSSGKSSFSITR CCCCCCCCCCEEEEE | 44.89 | 26320211 | |
555 | Ubiquitination | KGDFSSGKSSFSITR CCCCCCCCCCEEEEE | 44.89 | - | |
556 | Phosphorylation | GDFSSGKSSFSITRE CCCCCCCCCEEEEEE | 39.89 | 26239621 | |
557 | Phosphorylation | DFSSGKSSFSITREA CCCCCCCCEEEEEEE | 26.88 | 26239621 | |
559 | Phosphorylation | SSGKSSFSITREAQV CCCCCCEEEEEEEEE | 25.62 | 28973931 | |
561 | Phosphorylation | GKSSFSITREAQVNV CCCCEEEEEEEEEEE | 22.66 | 29899451 | |
572 | Phosphorylation | QVNVRMDSFDEDLAR EEEEECCCCCHHHHC | 25.84 | 24925903 | |
581 | Phosphorylation | DEDLARPSGLLAQER CHHHHCCCCHHHHHH | 36.20 | 28833060 | |
597 | Phosphorylation | LCRDLVHSNKKEQEF HHHHHHHCCHHHHHH | 42.75 | - | |
613 | Phosphorylation | SIFQHIQSAQSQRSP HHHHHHHHHHHCCCH | 27.89 | 26643407 | |
616 | Phosphorylation | QHIQSAQSQRSPSEL HHHHHHHHCCCHHHH | 27.55 | 26643407 | |
619 | Phosphorylation | QSAQSQRSPSELFAQ HHHHHCCCHHHHHHH | 25.74 | 25521595 | |
621 | Phosphorylation | AQSQRSPSELFAQHI HHHCCCHHHHHHHHH | 48.45 | 25521595 | |
630 | Phosphorylation | LFAQHIVTIVHHVKE HHHHHHHHHHHHHHH | 19.37 | 20415495 | |
653 | Ubiquitination | TLHERFTKYLKRGNE HHHHHHHHHHHHCCH | 45.96 | 27667366 | |
669 | Phosphorylation | EAAKNKKSPEIHRRI HHHHHCCCHHHHHHC | 29.40 | 25521595 | |
679 | Phosphorylation | IHRRIDISPSTFRKH HHHHCCCCHHHHHHC | 14.73 | 18388127 | |
681 | Phosphorylation | RRIDISPSTFRKHGL HHCCCCHHHHHHCCC | 33.13 | 24925903 | |
682 | Phosphorylation | RIDISPSTFRKHGLT HCCCCHHHHHHCCCC | 30.73 | 24925903 | |
685 | Acetylation | ISPSTFRKHGLTHEE CCHHHHHHCCCCHHH | 37.52 | 23806337 | |
689 | Phosphorylation | TFRKHGLTHEELKSP HHHHCCCCHHHHCCC | 31.65 | 25619855 | |
695 | Phosphorylation | LTHEELKSPREPGYK CCHHHHCCCCCCCCC | 41.64 | 26824392 | |
701 | Phosphorylation | KSPREPGYKAEGKYK CCCCCCCCCCCCCCC | 20.10 | 25159016 | |
706 | Acetylation | PGYKAEGKYKDDPVD CCCCCCCCCCCCCCH | 40.40 | 23806337 | |
734 | Phosphorylation | RDLKRGKSRESVDSR HHHHCCCCCHHHHCC | 44.07 | 27087446 | |
737 | Phosphorylation | KRGKSRESVDSRDSS HCCCCCHHHHCCCCC | 30.07 | 25159016 | |
740 | Phosphorylation | KSRESVDSRDSSHSR CCCHHHHCCCCCCCC | 35.51 | 27087446 | |
743 | Phosphorylation | ESVDSRDSSHSRERS HHHHCCCCCCCCCCC | 28.92 | 25159016 | |
744 | Phosphorylation | SVDSRDSSHSRERST HHHCCCCCCCCCCCC | 29.76 | 25159016 | |
746 | Phosphorylation | DSRDSSHSRERSTEK HCCCCCCCCCCCCHH | 37.47 | 25159016 | |
750 | Phosphorylation | SSHSRERSTEKTEKT CCCCCCCCCHHCHHH | 35.84 | 22817900 | |
776 | Phosphorylation | RARDRSRSSSSSSQS HHHHHCCCCCCCCCC | 35.50 | 23684622 | |
777 | Phosphorylation | ARDRSRSSSSSSQSS HHHHCCCCCCCCCCC | 32.88 | 25195567 | |
778 | Phosphorylation | RDRSRSSSSSSQSSH HHHCCCCCCCCCCCC | 35.17 | 29895711 | |
781 | Phosphorylation | SRSSSSSSQSSHSYK CCCCCCCCCCCCCCC | 35.71 | 29895711 | |
783 | Phosphorylation | SSSSSSQSSHSYKAE CCCCCCCCCCCCCHH | 31.78 | 29895711 | |
784 | Phosphorylation | SSSSSQSSHSYKAEE CCCCCCCCCCCCHHH | 14.60 | 29895711 | |
786 | Phosphorylation | SSSQSSHSYKAEEYP CCCCCCCCCCHHHCH | 30.21 | 29895711 | |
802 | Phosphorylation | EAEEREESTSGFDKS HHHHHHHHCCCCCHH | 24.10 | 25521595 | |
803 | Phosphorylation | AEEREESTSGFDKSR HHHHHHHCCCCCHHH | 35.83 | 23375375 | |
804 | Phosphorylation | EEREESTSGFDKSRL HHHHHHCCCCCHHHC | 46.90 | 27841257 | |
808 | Acetylation | ESTSGFDKSRLGTKD HHCCCCCHHHCCCCC | 34.90 | - | |
825 | Dimethylation | GPNERGGRARGTFQF CCCCCCCCCCEEEEE | 24.76 | - | |
825 | Methylation | GPNERGGRARGTFQF CCCCCCCCCCEEEEE | 24.76 | 82954755 | |
827 | Dimethylation | NERGGRARGTFQFRA CCCCCCCCEEEEEEE | 43.24 | - | |
827 | Methylation | NERGGRARGTFQFRA CCCCCCCCEEEEEEE | 43.24 | 24395871 | |
841 | Asymmetric dimethylarginine | ARGRGWGRGNYSGNN ECCCCCCCCCCCCCC | 24.55 | - | |
841 | Methylation | ARGRGWGRGNYSGNN ECCCCCCCCCCCCCC | 24.55 | 24129315 | |
860 | Phosphorylation | NNDFQKRSREEEWDP CCCHHHHHHHHHCCC | 51.59 | 18388127 | |
869 | Phosphorylation | EEEWDPEYTPKSKKY HHHCCCCCCCCCCCE | 33.46 | 25619855 | |
870 | Phosphorylation | EEWDPEYTPKSKKYY HHCCCCCCCCCCCEE | 23.68 | 25521595 | |
887 | Phosphorylation | DDREGEGSDKWMGRG CCCCCCCCCCCCCCC | 31.54 | 26643407 | |
904 | Dimethylation | RGAFPRGRGRFMFRK CCCCCCCCCCEEEEC | 34.10 | - | |
904 | Methylation | RGAFPRGRGRFMFRK CCCCCCCCCCEEEEC | 34.10 | 54541805 | |
906 | Dimethylation | AFPRGRGRFMFRKSS CCCCCCCCEEEECCC | 20.63 | - | |
906 | Methylation | AFPRGRGRFMFRKSS CCCCCCCCEEEECCC | 20.63 | 54541801 | |
912 | Phosphorylation | GRFMFRKSSTSPKWA CCEEEECCCCCCCCC | 34.29 | 23684622 | |
913 | Phosphorylation | RFMFRKSSTSPKWAH CEEEECCCCCCCCCC | 35.62 | 23684622 | |
914 | Phosphorylation | FMFRKSSTSPKWAHD EEEECCCCCCCCCCC | 57.02 | 23684622 | |
915 | Phosphorylation | MFRKSSTSPKWAHDK EEECCCCCCCCCCCC | 26.82 | 18779572 | |
924 | Phosphorylation | KWAHDKFSGEEGEIE CCCCCCCCCCCCCCC | 51.54 | 27087446 | |
935 | Phosphorylation | GEIEDDESGTENREE CCCCCCCCCCCCHHH | 58.99 | 27087446 | |
937 | Phosphorylation | IEDDESGTENREEKD CCCCCCCCCCHHHHH | 39.09 | 25521595 | |
945 | Phosphorylation | ENREEKDSLQPSAE- CCHHHHHHCCCCCC- | 39.72 | 25159016 | |
949 | Phosphorylation | EKDSLQPSAE----- HHHHCCCCCC----- | 31.88 | 25159016 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TR150_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TR150_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TR150_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of TR150_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-248; SER-253;SER-572 AND SER-679, AND MASS SPECTROMETRY. | |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119; SER-134; SER-238;SER-243; SER-248; SER-379; SER-572; SER-679; SER-695 AND SER-924, ANDMASS SPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; SER-53; SER-55;SER-264; SER-268; SER-315; SER-320; SER-403; SER-405; SER-572; SER-860AND SER-924, AND MASS SPECTROMETRY. | |
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-679, ANDMASS SPECTROMETRY. | |
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248; SER-253; SER-315;SER-320; THR-324; SER-679; SER-924; SER-935 AND THR-937, AND MASSSPECTROMETRY. | |
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248 AND SER-253, ANDMASS SPECTROMETRY. | |
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572 AND SER-935, ANDMASS SPECTROMETRY. | |
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, AND MASSSPECTROMETRY. |