ABC8A_MOUSE - dbPTM
ABC8A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABC8A_MOUSE
UniProt AC Q8K442
Protein Name ATP-binding cassette sub-family A member 8-A
Gene Name Abca8a
Organism Mus musculus (Mouse).
Sequence Length 1620
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description ATP-dependent lipophilic drug transporter..
Protein Sequence MVKREINVCQQTWALLCKNLLRKKRLKRDTFLEFLYTALILLSLILFLQLHEVYDFSSLPDVDLGRIDSFNDSTFMIVYTPITPTTQRIMDRVSLVSYMTGRKILASPNEENMTELISMRFSDVVGVIFTNAYSYNLKFIKGARIPTIKEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDSFVGQEGTTTDCFLFFCIIRFSPLTYYISAGVTRERKKMKGLMAVMGLRDSAFWLSWGLLYGVIVFVVTLLSTTIVKLVQFVFLTGFMVIFSLFFFYGLSLISLSFLMSVLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVSLEWLLSLLSPFAFMLGMVQLLRLDYDVNSNADPMGNPNEVIGTIFMLFFDGVFYLLLTFYFEKVLPSKSFHDKTYWHACKSHFFLIDYSFYIRTALDNETDYEFSDDSFEPVSMEFHGKEAIRIRNLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGKLSYILPLERTNKFPDLYRDLERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDVQAGGARSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERKSIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLLIVNKTGAKIDDFIHSLEQQNIALEVDAFGTRNGTEDSQYNGAIILSGDEKNYNFTLACNTKRLNCFPVLVDIVSNGLLGLFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVLLMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYCALILSIFIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFSMCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEIIFEPEREYSYLFFLAPLLHFAIFVVILRCMERKFGMKTMRTDPVFRISPRSDRVFNNPEDPDGEDEDVSQERVWTANALTSADFQEKPAIIASCLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGSSTGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQELDGFEEELDPSVKWKLLPQEEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
103AcetylationVSYMTGRKILASPNE
HHHHHCCCCCCCCCC		43.3415609841
454N-linked_GlycosylationYIRTALDNETDYEFS
EEEECCCCCCCCCCC		55.72-
482N-linked_GlycosylationKEAIRIRNLTKDYIQ
HHHHHHHHCCHHHHH		50.09-
485UbiquitinationIRIRNLTKDYIQKSK
HHHHHCCHHHHHHHH		52.2622790023
506UbiquitinationDLTLDVYKGQITAIL
HCCEEECCCCEEEEE		44.1622790023
544UbiquitinationWVTIHNNKLSEMTDL
EEEEECCCHHHCCCH		59.7222790023
584UbiquitinationLRLFAKIKGIQAHEV
HHHHHHCCCEEHHHC		49.6122790023
620UbiquitinationQNLSGGQKRKLTFGI
ECCCCCCCEEEEEEE		55.5722790023
658UbiquitinationHRVWNFLKERRADRV
HHHHHHHHHHCCCEE		45.0722790023
692UbiquitinationFISKGKLKCAGSSLF
EEECCCEEECCCEEE		26.0622790023
693S-palmitoylationISKGKLKCAGSSLFL
EECCCEEECCCEEEE		8.2128526873
735UbiquitinationKQHIPDSKLSAESEG
HHHCCCCCCCCCCCC		54.5722790023
743UbiquitinationLSAESEGKLSYILPL
CCCCCCCCEEEEEEC		30.1522790023
755UbiquitinationLPLERTNKFPDLYRD
EECCCCCCCCHHHHH		58.6322790023
791UbiquitinationVFLKLEGKSSIDQSD
HHHHHCCCCCCCHHH		31.4922790023
860PhosphorylationKLKHERKSIVILILV
CCHHHHHHHHHHHHH		28.4551457251
877PhosphorylationIGLLHILSANIYRMV
HHHHHHHHHHHHHHH		20.7551457263
881PhosphorylationHILSANIYRMVRQSD
HHHHHHHHHHHHCCC		7.7751457271
967N-linked_GlycosylationSGDEKNYNFTLACNT
ECCCCCCCEEEEECC		32.59-
1040PhosphorylationVPPYISMTSIDDYKN
CCCCCCCCCHHHHCC		18.7551457259
1107PhosphorylationDLFIQILYVGGYAMS
HHHHHHHHCCHHHHH		9.9351457255
1111PhosphorylationQILYVGGYAMSVIFM
HHHHCCHHHHHHHHH		8.0051457267
1114PhosphorylationYVGGYAMSVIFMTYV
HCCHHHHHHHHHHHH		12.1451457275
1328UbiquitinationLGHNGAGKSTSIKMI
ECCCCCCCCCEEEEE		50.4522790023
1340UbiquitinationKMITGETKPSAGQVL
EEECCCCCCCCCCEE		32.4522790023
1405UbiquitinationERLADALKLQDQLKS
HHHHHHHHHHHHHCC		45.9122790023
1415UbiquitinationDQLKSPVKTLSEGVK
HHHCCCCCHHCHHHH		47.3222790023
1519UbiquitinationYLLEMKVKTPSQVEP
HHEEEEECCHHHCCC		49.5622790023
1566UbiquitinationPLSQAFFKLETVKQS
HHHHHHHHHHHHHHC		38.6722790023
1611UbiquitinationEELDPSVKWKLLPQE
HCCCCCCCCEECCHH		42.8422790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABC8A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABC8A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABC8A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABC8A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABC8A_MOUSE

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Related Literatures of Post-Translational Modification

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