PKD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKD1_MOUSE
• UniProt AC: O08852
• Protein Name: Polycystin-1
• Gene Name: Pkd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 4293
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, cilium . PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autocatalytic cleavage at the GPS d
• Protein Description: Involved in renal tubulogenesis. [PubMed: 24939912 Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium]
• Protein Sequence: MPLGAPALLALALGLGLWLGALAGDPGRGCGPCPLPCFCGPAPDAACRVNCSGRWLQTLGPSLRIPADATALDLSHNLLQTLDIGLLVNLSALVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGLAWLPRWAKEHQVHVVQSEATTCRGPIPLAGQPLLSIPLLDNACGEEYVACLPDNSSGAVAAVPFYFAHEGPLETEACSAFCFSAGEGLAALSEQNQCLCGAGQASNSSAACSSWCSSISLSLNSACGGPTLLQHTFPASPGATLVGPHGPLASGQPADFHITSSLPISSTRWNFGDGSPEVDMASPAATHFYVLPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCPSFVHSNESLELGIRHRGGSALEVTYSILALDKEPAQVVHPLCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTWAGAALAMVDSPAIQHFLVSKVTRSLDVWIGFSSVEGTEGLDPRGEAFSLESCQNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDTENFVMGMSGGGLSGPLHPLAQQETVQGPLRPVEVMVFPGLSPSREAFLTAAEFSTQKLEEPAQMRLQVYRPSGGAAAVPEGSSEPDNRTEPAPKCVPEELWCPGANVCIPFDASCNSHVCINGSVSRLGLSRASYTLWKEFFFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPGTLLQCPLASSCPGQALYLSTNASDWMTNLPVHLEEAWAGPVCSLQLLLVTERLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIPLDGHIYVPTNGSVLVLQVDSGANATATAQWFGGNISAPFEDACPPEVDFLKQDCTEEANGTLFSVLMLPRLKEGDHTVEIVAQNGASQANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMVEAGSDVAFRWTIDDKQSLTFHNTVFNVIYQSAAIFKLSLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPTVLPPNATLALTGGVLVDSAVEVAFLWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYTTPGEYNLTVLVSNTYENLTQQVTVSVRTVLPNVAIGMSSNVLVAGQPITFSPYPLPSTDGVLYTWDFGDGSPVLIQSQPVLNHTYSMTGAYRITLEVNNTVSSVTAHADIRVFQELHGLTVYLSPSVEQGAPMVVSASVESGDNITWTFDMGDGTVFTGPEATVQHVYLRAQNFTVTVEAANPAGHLSQSLHVQVFVLEVLHIEPSTCIPTQPSAQLMAHVTGDPVHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVNKAHYFTSICVEPEIRNITLQPERQFVKLGDEARLVAYSWPPFPYRYTWDFGTEDTTHTQTGGSEVKFIYREPGSYLVIVTVSNNISSTNDSAFVEVQEPVLVTGIRINGSHVLELQQPYLLSAMGSGSPATYLWELGDGSQSEGPEVTHIYSSTGDFTVRVSGWNEVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFIYVLQFIEGLQVAGGDNGCCFPTNYTLQLQAAVRDGTNISYSWTAQQEGSLITLFGSGKCFSLTSLKASTYYVHLRATNMLGSAAANRTIDFVEPVESLILSASPNPAAVNMSLTLCAELAGGSGVVYTWYLEEGLSWKTSMPSTTHTFAAPGLHLVRVTAENQLGSVNATVEVAIQVPVGGLSIRTSEPDSIFVAAGSTLPFWGQLAEGTNVTWCWTLPGGSKDSQYIAVRFSTAGSFSLQLNASNAVSWVSAMYNLTVEEPIVNLMLWASSKVVAPGQPVHFEILLAAGSALTFRLQVGGSVPEVLPSPHFSHSFFRVGDHLVNVQAENHVSHAQAQVRILVLEAVVGLQVPNCCEPGMATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNLTLMVEVQDIIQYVTLQSGRCFTNRSARFEAATSPSPRRVTYHWDFGDGTPVQKTEEFWADHYYLRPGDYHVEVNATNLVSFFVAQATVTVQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEIYRTASCQRPGRMAQMVLPGVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLEDGDQTPLNFHWACVASTQSETGGCVLNFGPRGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGHCHNCSRGYKQGCWAARTFSNKTLVLNETTTSTGSTGMNLVVRPGALRDGEGYIFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLDSVRGLTTKVHFECTGWRDAEDGGAPLVYALLLKRCRQSYCENFCIYKGSLSTYGAVLPPGFQPLFVVSLAVVVQDQLGAAVVALNRSLTIVLPEPSGNPADLVPWLHSLTASVLPGLLKQADPQHVIEYSLALITVLNEYEQAPDVSEPNVEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILNITGDLIHLASLDMQGPQPLELGVEPPSLMVASKAYNLSSALMRILMRSRVLNEEPLTLAGEEIVALGKRSDPLSLLCYGKALGPSCHFSIPEAFSGALSNLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHNPVGSTIVQPQTSVSAVVTADNSNPQAGLHLRITYTVLNERYLSAEPEPYLAVYLHSVSQPNEYNCSASRRISLEVLEGADHRLYTFFIAPGTGTLDRSYYLNLTSHFHWSALEVSVGLYTSLCQYFSEEMMMWRTEGIVPLEETSPSQAVCLTRHLTAFGASLFVPPSHVQFIFPEPSASINYIVLLTCVICLVTYVVMAMILRKLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGIMLYGEDNRSGHRHLDGDRAFHRNSLDIFQIATPHSLGSVWKIRVWHDNKGLSPAWFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRVQRVTCCVLLLCLFLAANAVWYGVVRDTTYSMGPVSSLISPGVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPTGQQALDVDSYLDPSVLDSSLLTLSGLTEAFAGQVKNDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVVSSTLQRLTQGRPGCMLGSEEDGASLVSPSLPAKYLSASDEDLIHQVLADGANNLVPTQDTLLETDLLTSLSSVPGEKTETLILQTVGEERPASMGLSWEQSPVTRLSRTGLVEGFQKRLLPAWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSERVPRVRPPHGFALFLAKEEARKVKRLHDMLKRLLVYMLFLLVTLLANYGDASCHGHAYRLQSAIKQELDSQAFLAITRSDEFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSEHMCSAAGSLSTSDYGIGWQSVVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVCLLLFALYFSMAEVQTWRKDGCACTARPDTWARCLLVILTAATGLVRLAQLGIADRQWTHFVQDHPRHFTSFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCPGARVPTLCPSESWYLSPLLCVGLWALRVWGALRLGAILLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTSSSQPDGPSASLSRSTLKLEPEPSRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLQGHGHNGPPSSPSPGCFPGSQPALPSRLSRASQGLDQTVGPNRVSLWPNNKVHPSST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	N-linked_Glycosylation	PDAACRVNCSGRWLQ CCCCEEECCCCCHHH	8.55	-
52	Phosphorylation	AACRVNCSGRWLQTL CCEEECCCCCHHHHH	26.62	22871156
89	N-linked_Glycosylation	LDIGLLVNLSALVEL CCHHHHCCHHHHEEE	28.40	-
116	N-linked_Glycosylation	GVFANLFNLSEINLS CHHHHCCCCCEEECC	45.91	-
121	N-linked_Glycosylation	LFNLSEINLSGNPFE CCCCCEEECCCCCEE	24.89	-
187	N-linked_Glycosylation	YVACLPDNSSGAVAA EEEECCCCCCCCEEE	35.81	-
239	N-linked_Glycosylation	CGAGQASNSSAACSS CCCCCCCCCHHHHHH	42.89	-
370	N-linked_Glycosylation	CPSFVHSNESLELGI CHHHHCCCCCEEECC	28.18	-
627	N-linked_Glycosylation	EGSSEPDNRTEPAPK CCCCCCCCCCCCCCC	64.59	-
662	N-linked_Glycosylation	CNSHVCINGSVSRLG CCCCEEECCCHHHHC	31.40	-
740	N-linked_Glycosylation	QALYLSTNASDWMTN CEEEEECCHHHHHHC	33.79	-
804	N-linked_Glycosylation	GNSVSRQNLSCSFSV CCCCCCCCCEEEEEE	32.58	-
835	N-linked_Glycosylation	GHIYVPTNGSVLVLQ CEEEECCCCEEEEEE	34.37	-
848	N-linked_Glycosylation	LQVDSGANATATAQW EEECCCCCCEEEEEE	41.15	-
859	N-linked_Glycosylation	TAQWFGGNISAPFED EEEEECCCCCCCCCC	25.97	-
884	N-linked_Glycosylation	QDCTEEANGTLFSVL CCCCHHCCCCEEEEE	47.46	-
915	N-linked_Glycosylation	QNGASQANLSLRVTA CCCCCCCCEEEEEEE	23.64	-
998	N-linked_Glycosylation	TASNHVSNITVNYNV EECCCCCCEEEEEEE	38.85	-
1004	N-linked_Glycosylation	SNITVNYNVTVERMN CCEEEEEEEEEEHHH	20.13	-
1028	N-linked_Glycosylation	VPTVLPPNATLALTG CCCCCCCCCEEEEEC	43.55	-
1084	N-linked_Glycosylation	AQVLVEHNTTHIYTT HHHEEECCCCEEEEC	32.92	-
1096	N-linked_Glycosylation	YTTPGEYNLTVLVSN EECCCEEEEEEEEEC	25.57	-
1107	N-linked_Glycosylation	LVSNTYENLTQQVTV EEECCCCCCCCEEEE	37.66	-
1172	N-linked_Glycosylation	IQSQPVLNHTYSMTG EECCCCCCEEEECCE	26.20	-
1188	N-linked_Glycosylation	YRITLEVNNTVSSVT EEEEEEECCEECCEE	29.13	-
1234	N-linked_Glycosylation	ASVESGDNITWTFDM EEEECCCCEEEEEEC	36.80	-
1263	N-linked_Glycosylation	HVYLRAQNFTVTVEA EEEEECCCEEEEEEE	33.30	-
1330	N-linked_Glycosylation	TFGDGSSNVTVHGHP ECCCCCCCEEEECCC	34.87	-
1342	N-linked_Glycosylation	GHPSVTHNFTRSGIF CCCCCCCCCCCCCCH	30.53	-
1376	N-linked_Glycosylation	CVEPEIRNITLQPER EECHHHHCCCCCCCH	36.94	-
1444	N-linked_Glycosylation	VIVTVSNNISSTNDS EEEEEECCCCCCCCC	28.19	-
1449	N-linked_Glycosylation	SNNISSTNDSAFVEV ECCCCCCCCCCEEEE	43.09	-
1468	N-linked_Glycosylation	LVTGIRINGSHVLEL EEEEEEECCEEEEEE	35.75	-
1535	N-linked_Glycosylation	SRSEAQLNITVKQRV CCCEEEECCEEEHHH	18.79	-
1548	N-linked_Glycosylation	RVRGLTINASRTVVP HHCCEEEECCCCEEE	26.99	-
1557	N-linked_Glycosylation	SRTVVPLNGSVSFST CCCEEECCCEEEEHH	34.32	-
1643	N-linked_Glycosylation	NGCCFPTNYTLQLQA CCCCCCCCCEEEEEE	28.20	-
1657	N-linked_Glycosylation	AAVRDGTNISYSWTA EEECCCCCEEEEEEE	27.09	-
1681	Phosphorylation	FGSGKCFSLTSLKAS EECCEEEEEEECCEE	39.96	22324799
1683	Phosphorylation	SGKCFSLTSLKASTY CCEEEEEEECCEEEE	30.71	22324799
1684	Phosphorylation	GKCFSLTSLKASTYY CEEEEEEECCEEEEE	32.92	22324799
1706	N-linked_Glycosylation	MLGSAAANRTIDFVE CCCHHHHCCCCCEEC	36.58	-
1730	N-linked_Glycosylation	SPNPAAVNMSLTLCA CCCHHHHHHHHHHHH	15.03	-
1788	N-linked_Glycosylation	ENQLGSVNATVEVAI CCCCCCCCEEEEEEE	31.43	-
1831	N-linked_Glycosylation	GQLAEGTNVTWCWTL CCCCCCCCEEEEEEC	39.83	-
1863	N-linked_Glycosylation	GSFSLQLNASNAVSW CEEEEEECCCCHHHH	28.50	-
1876	N-linked_Glycosylation	SWVSAMYNLTVEEPI HHHHHHHCCCCCCCH	19.02	-
1987	N-linked_Glycosylation	MATGTEKNFTARVQR CCCCCCCCCEEECCC	33.01	-
2046	N-linked_Glycosylation	FNELGGVNLTLMVEV CHHCCCCCEEEEEEH	30.50	-
2070	N-linked_Glycosylation	QSGRCFTNRSARFEA CCCCCCCCCCCEEEE	18.69	-
2121	N-linked_Glycosylation	GDYHVEVNATNLVSF CCEEEEECCHHHHEE	27.78	-
2244	N-linked_Glycosylation	LARSIQANVTVAAER HHHHHHHCCEEEEHH	17.39	-
2333	Phosphorylation	LEAGVEYTFNLIVWK HCCCCEEEEEEEEEE	7.79	-
2349	N-linked_Glycosylation	GRKEEATNQTVLIRS CCCCCCCCCEEEEEC	42.44	-
2391	N-linked_Glycosylation	YLEGHCHNCSRGYKQ EEECCCCCCCHHHCC	30.74	-
2408	N-linked_Glycosylation	WAARTFSNKTLVLNE EEEEEECCCEEEEEE	36.82	-
2414	N-linked_Glycosylation	SNKTLVLNETTTSTG CCCEEEEEEEECCCC	36.77	-
2563	N-linked_Glycosylation	GAAVVALNRSLTIVL CHHHEEEECCEEEEC	23.04	-
2640	N-linked_Glycosylation	LRAQMRKNITETLIS HHHHHHHCHHHHHHH	35.73	-
2647	Phosphorylation	NITETLISLRVNTVD CHHHHHHHHCCCCHH	17.15	-
2713	N-linked_Glycosylation	TIADSILNITGDLIH HHHHHHHHHCCHHHH	28.27	-
2715	Phosphorylation	ADSILNITGDLIHLA HHHHHHHCCHHHHHH	24.46	-
2749	N-linked_Glycosylation	MVASKAYNLSSALMR HHHHHHCCHHHHHHH	38.00	-
2808	Phosphorylation	FSIPEAFSGALSNLS CCCCHHHHHHHCCHH	30.15	-
2813	N-linked_Glycosylation	AFSGALSNLSDVVQL HHHHHHCCHHHHHHH	44.40	-
2836	N-linked_Glycosylation	FPFGYISNYTVSTKV CCCCEEECEEEECCE	27.26	-
2873	N-linked_Glycosylation	AITVKVPNNSDQAAQ CEEEECCCCHHHHHH	64.72	-
2948	N-linked_Glycosylation	VSQPNEYNCSASRRI CCCCCCCCCCCCCEE	13.69	-
2986	N-linked_Glycosylation	LDRSYYLNLTSHFHW CCCCEEECCCCCCCH	25.75	-
3456	Phosphorylation	SLPAKYLSASDEDLI CCCHHHCCCCCHHHH	23.72	23608596
3458	Phosphorylation	PAKYLSASDEDLIHQ CHHHCCCCCHHHHHH	37.85	23608596
3521	Phosphorylation	MGLSWEQSPVTRLSR CCCCCCCCCCHHHHC	15.15	23737553
3524	Phosphorylation	SWEQSPVTRLSRTGL CCCCCCCHHHHCCCC	29.31	21183079
3623	Phosphorylation	EDDTLVESPAVTPVS CCCCCCCCCCCCCHH	15.64	26824392
3728	N-linked_Glycosylation	FLPYVHGNQSSPELG CCCCCCCCCCCCCCC	24.55	-
3780	N-linked_Glycosylation	GWQSVVQNGSETWAY CCHHHCCCCCEECEE	44.33	-
4156	Phosphorylation	DPLPSRSSRGSKSSP CCCCCCCCCCCCCCC	39.28	-
4159	Phosphorylation	PSRSSRGSKSSPVVL CCCCCCCCCCCCEEC	28.40	10364454

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4156	S	Phosphorylation	Kinase	PRKX	Q922R0	Uniprot
4159	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
4159	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK2_MOUSE	Jak2	physical	12007403
PKD2_MOUSE	Pkd2	physical	11901144

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.