| UniProt ID | AN13B_MOUSE | |
|---|---|---|
| UniProt AC | Q5F259 | |
| Protein Name | Ankyrin repeat domain-containing protein 13B | |
| Gene Name | Ankrd13b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 626 | |
| Subcellular Localization | Cell membrane. Late endosome. Early endosome. Interaction with EGFR may enhance association with the cell membrane.. | |
| Protein Description | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).. | |
| Protein Sequence | MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPMLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYMETLALAGQDRELLLAAAQPSEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPPAITAEEYFNPNFELGNRAMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPGSETPSPGSDSSSVSSSSSTTSCRACEISPALFEAPRGYSVLGGQREAVPRDEDDDLLRFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPMPPAPVPSPRPSPGPGSSSHVFRSYDEQLRLAMELSAQEQEERRRRVRQEEEELERILRLSLTEQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MIPANASA -------CCCCCCCC | 8.16 | - | |
| 57 | Phosphorylation | TPLHLATTLGHLECA CCHHHHHHHHHHHHH | 25.74 | 108431031 | |
| 145 | Phosphorylation | TSWVPLVSKICPSDT CCHHHHHHHHCCCCC | 24.80 | 20047950 | |
| 364 | Acetylation | RPMELTTKTQKFKAK CCCCCCCCCHHHHHE | 43.66 | 19850971 | |
| 449 | Phosphorylation | PVPSVRGSPGSETPS CCCCCCCCCCCCCCC | 18.61 | 22871156 | |
| 463 | Phosphorylation | SPGSDSSSVSSSSST CCCCCCCCCCCCCCC | 29.94 | 22871156 | |
| 469 | Phosphorylation | SSVSSSSSTTSCRAC CCCCCCCCCCCCEEC | 37.34 | 22871156 | |
| 489 | Phosphorylation | LFEAPRGYSVLGGQR HHCCCCCCCCCCCCC | 9.26 | 50565339 | |
| 490 | Phosphorylation | FEAPRGYSVLGGQRE HCCCCCCCCCCCCCC | 17.43 | 50565347 | |
| 533 | Phosphorylation | VTIWEALTNSKPGTH EEHHHHHHCCCCCCC | 44.48 | 51459989 | |
| 535 | Phosphorylation | IWEALTNSKPGTHPM HHHHHHCCCCCCCCC | 34.68 | 51459997 | |
| 539 | Phosphorylation | LTNSKPGTHPMSYEG HHCCCCCCCCCCCCC | 31.19 | 51460005 | |
| 556 | Phosphorylation | QDRSAPPTPQRQPMP CCCCCCCCCCCCCCC | 30.87 | 23384938 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AN13B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AN13B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AN13B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AN13B_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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