K2C78_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C78_HUMAN
• UniProt AC: Q8N1N4
• Protein Name: Keratin, type II cytoskeletal 78
• Gene Name: KRT78
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Protein Sequence: MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLSPCRAQ ------CCCCCCCCC	37.24	30177828
4	Phosphorylation	----MSLSPCRAQRG ----CCCCCCCCCCC	18.04	29457462
7 (in isoform 2)	Phosphorylation	-	36.82	29083192
22	Phosphorylation	RSACSARSRGRSRGG HHHHHHHHCCCCCCC	38.51	20068231
26	Phosphorylation	SARSRGRSRGGFSSR HHHHCCCCCCCCCCC	37.79	20068231
27	Ubiquitination	ARSRGRSRGGFSSRG HHHCCCCCCCCCCCC	48.14	16196087
37	Phosphorylation	FSSRGGFSSRSLNSF CCCCCCCCCCCCCCC	28.28	-
40	Phosphorylation	RGGFSSRSLNSFGGC CCCCCCCCCCCCCCC	33.57	28348404
94	Phosphorylation	TINQNLLTPLKIEID EECCCCCCCEEEEEC	29.73	-
124	Phosphorylation	TLNNQFASFIDKVRF HHHHHHHHHHHHHHH	24.83	28355574
128	Acetylation	QFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7706029
128	Ubiquitination	QFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	22817900
137	Ubiquitination	RFLEQQNKVLETKWH HHHHHHHHHHHHHHH	43.81	16196087
259	Phosphorylation	EELGQLQTQASDTSV HHHHHHCCCCCCCEE	34.39	20068231
262	Phosphorylation	GQLQTQASDTSVVLS HHHCCCCCCCEEEEE	31.44	20068231
264	Phosphorylation	LQTQASDTSVVLSMD HCCCCCCCEEEEEEC	22.41	20068231
265	Phosphorylation	QTQASDTSVVLSMDN CCCCCCCEEEEEECC	18.41	20068231
269	Phosphorylation	SDTSVVLSMDNNRYL CCCEEEEEECCCCEE	16.69	20068231
295	Phosphorylation	RYEEIARSSKAEAEA HHHHHHHCCHHHHHH	27.46	22210691
296	Phosphorylation	YEEIARSSKAEAEAL HHHHHHCCHHHHHHH	30.27	22210691
304	Phosphorylation	KAEAEALYQTKYQEL HHHHHHHHHHHHHHH	22.60	22210691
306	Phosphorylation	EAEALYQTKYQELQV HHHHHHHHHHHHHHH	20.40	-
330	Phosphorylation	QETKVQISQLHQEIQ HHHHHHHHHHHHHHH	15.03	24173317
412	Phosphorylation	SLDVEIATYRRLLEG CCHHHHHHHHHHHCC	24.19	-
413	Phosphorylation	LDVEIATYRRLLEGE CHHHHHHHHHHHCCC	5.68	-
433	Phosphorylation	GECTSQVTISSVGGS CCCCCCEEEEEECCC	13.91	22210691
453	Phosphorylation	GVGGGLGSTCGLGSG CCCCCCCCCCCCCCC	26.10	22210691
454	Phosphorylation	VGGGLGSTCGLGSGK CCCCCCCCCCCCCCC	14.59	22210691
509	Phosphorylation	CHTILKKTVESSLKT HHHHHHHHHHHHHHC	28.11	29083192
512	Phosphorylation	ILKKTVESSLKTSIT HHHHHHHHHHHCCCC	36.31	22468782
513	Phosphorylation	LKKTVESSLKTSITY HHHHHHHHHHCCCCC	22.00	29083192
516	Phosphorylation	TVESSLKTSITY--- HHHHHHHCCCCC---	30.56	-
517	Phosphorylation	VESSLKTSITY---- HHHHHHCCCCC----	16.02	-
520	Phosphorylation	SLKTSITY------- HHHCCCCC-------	18.19	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C78_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C78_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C78_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C78_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.