NAV3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAV3_MOUSE
• UniProt AC: Q80TN7
• Protein Name: Neuron navigator 3
• Gene Name: Nav3
• Organism: Mus musculus (Mouse).
• Sequence Length: 2359
• Subcellular Localization: Nucleus outer membrane .
• Protein Description: May regulate IL2 production by T-cells. May be involved in neuron regeneration..
• Protein Sequence: MPVLGVASKLRQPAVGPKPVHAALPIPNLGISVSRRCSSRPLEFATPERSMLSCQLTLKSTCEFGEKKALQGTAKEIEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLADIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHTAPQSEASQAKTQQDMQSSLTARYAAQSKHSGIATSQKKPTRLPGPSRVPAASSSNKAQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSPKGPQPSSGINGNTQPPSTSGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQPSPATSPTPSSDRLKPPVTEGVKSAPSGQKSMLEKFKLVNARTALRPPQAPSSGPNDGGREDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLTPPKAGSKNFSNKKSLLQPKEKEEKTRDKNKACAEKSGKEEKDQVTTEAAPKKTSKIASLIPKGSKTAAAKKESLIPSSSGIPKPGSKVPTPKQTISPGSAASKESEKFRTSKGSSSQAFPKAITAEKASTPSLSTPLDGREAGQASPSSSCVMQVTHSSGQSPGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTSLPPADSCTSPTKMDSSYSKTAKQCLEEISGEDPEARRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDTTVTTEVNGRAIPNLTSRPSPMTWRLGQACPRLQAGDAPSMGAGYSRSGTSRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDVSSEVDVGGYMSDGDILGKSLRADDINSGYMTDGGLNLYTRSLNRVPDTATSRDVIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSISSYSNITVPSRKNTQLKTDAEKRSTTDETWDSPEELKKAEGDCDSHGDGAAKWKGATSGLAEDSEKTGQKASLSVSQTGSWRRGMSAQGGTPATARQKTSTSALKTPGKTDDAKASEKGKTPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTASSSFGYKKPSGVGASTMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGAKSSSVVLSPSTSLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPAPSMMRSSSIPAQDSSFDLYDDAQLCGSATSLEERPRAVSHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGESGSSSMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPARPPSDSSSTASSSSSRQSLGLSLNNLNITESVTSDILLDDTGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSSSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYVLEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEACTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYPSTQSCDGDSVSHREDILDTSIESTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
273	Phosphorylation	ASNLNRRSQSFNSID CCHHHHHHHCHHCCC	27.26	25619855
275	Phosphorylation	NLNRRSQSFNSIDKN HHHHHHHCHHCCCCC	27.86	25619855
278	Phosphorylation	RRSQSFNSIDKNKPP HHHHCHHCCCCCCCC	30.10	29899451
334	Phosphorylation	SASKPWRSKSMNVKH CCCCCCCCCCCCCCC	25.80	20139300
336	Phosphorylation	SKPWRSKSMNVKHSA CCCCCCCCCCCCCCE	19.48	20139300
342	Phosphorylation	KSMNVKHSATSTMLT CCCCCCCCEEEEEEE	27.76	20139300
354	Phosphorylation	MLTVKQPSPATSPTP EEEECCCCCCCCCCC	25.36	24899341
357	Phosphorylation	VKQPSPATSPTPSSD ECCCCCCCCCCCCHH	38.33	29514104
358	Phosphorylation	KQPSPATSPTPSSDR CCCCCCCCCCCCHHC	28.96	24899341
360	Phosphorylation	PSPATSPTPSSDRLK CCCCCCCCCCHHCCC	35.25	29899451
376	Phosphorylation	PVTEGVKSAPSGQKS CCCCCCCCCCCCCHH	42.90	22817900
518	Acetylation	SKTAAAKKESLIPSS CCHHHHHHHHCCCCC	48.05	7719649
543	Phosphorylation	PTPKQTISPGSAASK CCCCCCCCCCCCCCC	26.96	25338131
645	Phosphorylation	AHSENEGTSLPPADS CCCCCCCCCCCCCHH	22.40	24899341
652	Phosphorylation	TSLPPADSCTSPTKM CCCCCCHHCCCCCCC	22.77	29899451
735	Phosphorylation	GRAIPNLTSRPSPMT CEECCCCCCCCCCCC	29.36	28576409
784	Phosphorylation	PSRFMYTTPLRRAAV HHHCCCCHHHHHHHH	11.66	27149854
843	Phosphorylation	DINSGYMTDGGLNLY CCCCCCCCCCCEEEE	24.02	29514104
853	Phosphorylation	GLNLYTRSLNRVPDT CEEEEECCCCCCCCC	23.38	25338131
941	Phosphorylation	TTDETWDSPEELKKA CCCCCCCCHHHHHHH	26.27	25619855
1040	Phosphorylation	KGSSLQRSPSDAGKS CCCCCCCCHHHCCCC	18.78	25619855
1042	Phosphorylation	SSLQRSPSDAGKSSG CCCCCCHHHCCCCCC	41.14	25619855
1047	Phosphorylation	SPSDAGKSSGDEGKK CHHHCCCCCCCCCCC	38.34	25619855
1048	Phosphorylation	PSDAGKSSGDEGKKP HHHCCCCCCCCCCCC	54.47	25619855
1057	Phosphorylation	DEGKKPPSGIGRSTA CCCCCCCCCCCCCCC	52.12	25619855
1084	O-linked_Glycosylation	GASTMITSSGATITS CCCEEEECCCCEEEC	18.82	55412793
1095	Phosphorylation	TITSGSATLGKIPKS EEECCCCCCCCCCHH	37.43	-
1115	Phosphorylation	KSNAGRKTSLDGSQN CCCCCCCCCCCCCCC	32.91	25619855
1116	Phosphorylation	SNAGRKTSLDGSQNQ CCCCCCCCCCCCCCC	27.74	25619855
1120	Phosphorylation	RKTSLDGSQNQDDVV CCCCCCCCCCCCCEE	26.14	25619855
1140	Phosphorylation	KTTLQYRSLPRPSKS CCEEEEECCCCCCCC	37.48	21454597
1147	Phosphorylation	SLPRPSKSSTSGIPG CCCCCCCCCCCCCCC	43.09	29899451
1155	Methylation	STSGIPGRGGHRSST CCCCCCCCCCCCCCC	42.43	16187537
1160	Phosphorylation	PGRGGHRSSTSSIDS CCCCCCCCCCCCCCC	32.09	29899451
1162	Phosphorylation	RGGHRSSTSSIDSNV CCCCCCCCCCCCCCC	27.95	29899451
1189	Phosphorylation	REPTKIGSGRSSPVT CCCCCCCCCCCCCCC	34.21	29899451
1192	Phosphorylation	TKIGSGRSSPVTVNQ CCCCCCCCCCCCCCC	42.38	29899451
1193	Phosphorylation	KIGSGRSSPVTVNQT CCCCCCCCCCCCCCC	23.25	25521595
1196	Phosphorylation	SGRSSPVTVNQTDKE CCCCCCCCCCCCCHH	19.68	23684622
1200	Phosphorylation	SPVTVNQTDKEKEKV CCCCCCCCCHHCCEE	43.78	25777480
1210	Phosphorylation	EKEKVAVSDSESVSL HCCEEEECCCCCCCC	26.19	25619855
1210	O-linked_Glycosylation	EKEKVAVSDSESVSL HCCEEEECCCCCCCC	26.19	22517741
1212	Phosphorylation	EKVAVSDSESVSLSG CEEEECCCCCCCCCC	25.02	25619855
1214	Phosphorylation	VAVSDSESVSLSGSP EEECCCCCCCCCCCC	22.43	29514104
1216	Phosphorylation	VSDSESVSLSGSPKS ECCCCCCCCCCCCCC	26.54	25619855
1218	Phosphorylation	DSESVSLSGSPKSSP CCCCCCCCCCCCCCC	29.71	25619855
1220	Phosphorylation	ESVSLSGSPKSSPTS CCCCCCCCCCCCCCC	26.27	25619855
1226	Phosphorylation	GSPKSSPTSASACGT CCCCCCCCCHHHCCC	38.58	28576409
1248	Phosphorylation	SKYPDIASPTFRRLF CCCCCCCCHHHHHHH	25.47	21659605
1250	Phosphorylation	YPDIASPTFRRLFGA CCCCCCHHHHHHHCH	27.55	28066266
1423	Phosphorylation	SMQLDRNTLPKKGLR HHCCCCCCCCCCCCC	45.38	29899451
1449	Phosphorylation	EGKEWLRSHSTGGLQ HHHHHHHHCCCCCCC	21.44	25619855
1451	Phosphorylation	KEWLRSHSTGGLQDT HHHHHHCCCCCCCCC	29.96	25619855
1452	Phosphorylation	EWLRSHSTGGLQDTG HHHHHCCCCCCCCCC	29.82	25619855
1458	Phosphorylation	STGGLQDTGNQSPLV CCCCCCCCCCCCCCC	25.68	25619855
1462	Phosphorylation	LQDTGNQSPLVSPSA CCCCCCCCCCCCHHH	24.97	25619855
1466	Phosphorylation	GNQSPLVSPSAMSSS CCCCCCCCHHHCCCC	22.33	25619855
1468	Phosphorylation	QSPLVSPSAMSSSAT CCCCCCHHHCCCCCC	29.15	25619855
1478	Phosphorylation	SSSATGKYHFSNLVS CCCCCCCEECCCCCC	14.94	23984901
1481	Phosphorylation	ATGKYHFSNLVSPTN CCCCEECCCCCCCCC	18.88	23984901
1485	Phosphorylation	YHFSNLVSPTNLSQF EECCCCCCCCCHHHC	29.22	23984901
1487	Phosphorylation	FSNLVSPTNLSQFNL CCCCCCCCCHHHCCC	41.09	21183079
1490	Phosphorylation	LVSPTNLSQFNLPAP CCCCCCHHHCCCCCC	34.49	23984901
1535	Phosphorylation	EERPRAVSHSGSFRD HHCCCHHCCCCCHHH	15.79	25338131
1620	Phosphorylation	TGRLQSLTMTAEQKE HHHHHHHEECHHHHH	20.09	28576409
1622	Phosphorylation	RLQSLTMTAEQKESE HHHHHEECHHHHHHH	23.08	28576409
1672	Phosphorylation	LRIRRQHSSESVSSI HHHHHCCCCCCHHHC	27.71	19060867
1673	Phosphorylation	RIRRQHSSESVSSIN HHHHCCCCCCHHHCH	31.59	25777480
1675	Phosphorylation	RRQHSSESVSSINSA HHCCCCCCHHHCHHC	29.28	25777480
1677	Phosphorylation	QHSSESVSSINSATS CCCCCCHHHCHHCCC	34.48	25777480
1678	Phosphorylation	HSSESVSSINSATSH CCCCCHHHCHHCCCC	24.51	25777480
1681	Phosphorylation	ESVSSINSATSHSSI CCHHHCHHCCCCCCC	31.11	23608596
1683	Phosphorylation	VSSINSATSHSSIGS HHHCHHCCCCCCCCC	27.13	23608596
1684	Phosphorylation	SSINSATSHSSIGSG HHCHHCCCCCCCCCC	22.53	23608596
1687	Phosphorylation	NSATSHSSIGSGNDA HHCCCCCCCCCCCCC	26.08	-
1707	Phosphorylation	KKKNWLRSSFKQAFG HHHHHHHHHHHHHHC	37.65	23984901
1708	Phosphorylation	KKNWLRSSFKQAFGK HHHHHHHHHHHHHCC	29.99	23984901
1723	Phosphorylation	KKSTKPPSSHSDIEE CCCCCCCCCCCCHHH	49.57	25619855
1724	Phosphorylation	KSTKPPSSHSDIEEL CCCCCCCCCCCHHHH	32.55	25619855
1726	Phosphorylation	TKPPSSHSDIEELTD CCCCCCCCCHHHHCC	42.08	25619855
1739	Phosphorylation	TDSSLPASPKLPHNA CCCCCCCCCCCCCCC	22.19	25619855
1789	Phosphorylation	REKELKLTDIRLEAL HHHHCCCHHHHHHHH	28.00	22871156
1797	Phosphorylation	DIRLEALSSAHHLDQ HHHHHHHHHHHHHHH	32.31	22871156
1798	Phosphorylation	IRLEALSSAHHLDQI HHHHHHHHHHHHHHH	32.26	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAV3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAV3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAV3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NAV3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.