dbPTM

MKL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MKL2_MOUSE
UniProt AC	P59759
Protein Name	MKL/myocardin-like protein 2
Gene Name	Mkl2
Organism	Mus musculus (Mouse).
Sequence Length	1080
Subcellular Localization	Nucleus.
Protein Description	Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation..
Protein Sequence	MIDSSKKQPQGFPEILTAEDFEPFKEKECLEGSNQKSLKEVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVVKEDYPHTHGEFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSASPPPVTASTPAQFTSVSPAVPEFLKTPLTADQPPTRSTAPVLPTNTVSSAKSGPMLVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPNQKGEKSEPQMDSNYARLLQQQQLFLQLQILSQQQQQQQQQHYNYQTILPAPIKTDKNSSSGSNSGSSSSMPARRPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVTSSNLATGSIVAVSSATIVTSNPEVTVALPVTTLHNAVTSSVSTFKADLALPATSSVPHVENAHSPLPISPSPSEQSSLSTDDTNMTDTFTEIMTMMSPSQLLCSSPLRVVSHDDSLSPSSSTLSTLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQRPPDPQPSDPPHPFNTSDPKHGSVGSSIKDEASLPDCSSPQQPITVPGHSVGQPISTGSQTLVAKKTVVVKQEVPMAQAEQQNVVSQFYLSSQGQPPALVAQPQALLTTQTTQLLLPVSIQGSNVTSVQLPVGSLQLQTPAQGRVQAQPHVAAATQVPAAALPSALTSALPQKQEAFPQHVLGQPQPVRKVFTNSAPNTVLQYQRQPGPTNQQPFVSKTSNPALQSRTAPLAPLQNGPSLASKPSSPPPPQQFVVQHSLFATPITKTKDPPRYEEAIKQTRSTQPALPEVSSVHSQQMDDLFDILIKSGEISFPIKEEPSPISKMKPVTASITTMPVNTVVSRPPPQVQIAPPVSLEPVNSLSASLENQLEAFLDGTLPSATDTGPLQNSSEDRESFSLIEDLQNDLLSHSSMLYQSHSPMETSEAQLVSGTPCLSLDLSDSNLDNMEWLDITMPTTSSGLTPLSTTAPSMFSADFLDPQDLPLPWD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
811	Acetylation	NQQPFVSKTSNPALQ CCCCCCCCCCCHHHH	51.15	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MKL2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MKL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MKL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MKL2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MKL2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.	19367708 [Abstract]