K2C6A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C6A_MOUSE
• UniProt AC: P50446
• Protein Name: Keratin, type II cytoskeletal 6A
• Gene Name: Krt6a
• Organism: Mus musculus (Mouse).
• Sequence Length: 553
• Protein Description: Epidermis-specific type I keratin involved in wound healing. [PubMed: 10866680 Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration]
• Protein Sequence: MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGGSSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGSFGIGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTINQSLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSIIGERGRLDSELRNMQDTVEDYKSKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADSLTDDINFLRALYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGGSSYSYSSSHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTTSSSKKSYRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	STKTTIKSQTSHRGY CCCCEECCCCCCCCC	34.54	-
17	Phosphorylation	QTSHRGYSASSARVP CCCCCCCCCCCCCCC	25.21	19367708
19	Phosphorylation	SHRGYSASSARVPGL CCCCCCCCCCCCCCC	20.70	21082442
20	Phosphorylation	HRGYSASSARVPGLN CCCCCCCCCCCCCCC	21.58	19367708
29	Phosphorylation	RVPGLNRSGFSSVSV CCCCCCCCCCCEEEE	43.02	19367708
35	Phosphorylation	RSGFSSVSVCRSRGS CCCCCEEEEEECCCC	19.90	22817900
39	Phosphorylation	SSVSVCRSRGSGGSS CEEEEEECCCCCCCC	35.55	22817900
40	Methylation	SVSVCRSRGSGGSSA EEEEEECCCCCCCCC	24.76	31122779
42	Phosphorylation	SVCRSRGSGGSSAMC EEEECCCCCCCCCCC	38.58	19367708
58	Phosphorylation	GAGFGSRSLYGVGSS CCCCCCCCEECCCCC	27.86	22817900
69	Phosphorylation	VGSSKRISIGGGSCG CCCCCEEEECCCCCC	21.15	22817900
74	Phosphorylation	RISIGGGSCGIGGGY EEEECCCCCCCCCCC	16.67	19367708
150	Phosphorylation	PTIQRVRTEEREQIK CCHHHHCHHHHHHHH	39.06	-
158	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
162	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
165	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
169	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	27667366
178	Ubiquitination	RFLEQQNKVLDTKWA HHHHHHHCHHHHHHH	39.58	-
183	Ubiquitination	QNKVLDTKWALLQEQ HHCHHHHHHHHHHHH	30.09	-
226	Phosphorylation	GERGRLDSELRNMQD CCCCHHHHHHHHCHH	43.02	22817900
258	Phosphorylation	AAENEFVTLKKDVDA HHHCCCEEEEHHHCH	37.87	21659604
316	Phosphorylation	LSMDNNRSLDLDSII EECCCCCCCCHHHHH	28.49	22817900
321	Phosphorylation	NRSLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	22817900
358	Dimethylation	ELQVTAGRHGDDLRN HHHHHCCCCCCHHHH	28.31	-
415	Acetylation	ALKDARGKLEGLEDA HHHHHHHHHCCHHHH	37.50	7461943
435	Acetylation	QDMARLLKEYQELMN HHHHHHHHHHHHHHC	59.99	7612025
456	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C6A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C6A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C6A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.