ML12B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ML12B_MOUSE
• UniProt AC: Q3THE2
• Protein Name: Myosin regulatory light chain 12B
• Gene Name: Myl12b
• Organism: Mus musculus (Mouse).
• Sequence Length: 172
• Protein Description: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion..
• Protein Sequence: MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSKKAKTK ------CCCCCCCCC	51.36	17928407
3	Phosphorylation	-----MSSKKAKTKT -----CCCCCCCCCC	36.56	17928407
19	Phosphorylation	KKRPQRATSNVFAMF CCCCCHHHHHHHHHC	24.03	27087446
20	Phosphorylation	KRPQRATSNVFAMFD CCCCHHHHHHHHHCC	29.97	27087446
29	Phosphorylation	VFAMFDQSQIQEFKE HHHHCCHHHHHHHHH	30.97	24925903
51	Ubiquitination	NRDGFIDKEDLHDML CCCCCCCHHHHHHHH	48.59	22790023
109	S-palmitoylation	VIRNAFACFDEEATG HHHHHHHHCCCCCCC	3.40	28680068
128	Phosphorylation	DYLRELLTTMGDRFT HHHHHHHHHCCCCCC	27.62	26525534
135	Phosphorylation	TTMGDRFTDEEVDEL HHCCCCCCHHHHHHH	43.31	26525534
143	Phosphorylation	DEEVDELYREAPIDK HHHHHHHHHHCCCCC	12.36	25338131
150	Ubiquitination	YREAPIDKKGNFNYI HHHCCCCCCCCCCCE	64.40	22790023
151	Ubiquitination	REAPIDKKGNFNYIE HHCCCCCCCCCCCEE	56.17	-
151	Acetylation	REAPIDKKGNFNYIE HHCCCCCCCCCCCEE	56.17	23806337
151	Succinylation	REAPIDKKGNFNYIE HHCCCCCCCCCCCEE	56.17	-
151	Malonylation	REAPIDKKGNFNYIE HHCCCCCCCCCCCEE	56.17	26320211
156	Phosphorylation	DKKGNFNYIEFTRIL CCCCCCCCEEHHHHH	9.55	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	PRKCA	P04409	GPS
19	T	Phosphorylation	Kinase	DAPK1	Q80YE7	PSP
19	T	Phosphorylation	Kinase	DAPK3	O54784	Uniprot
19	T	Phosphorylation	Kinase	MLCK	-	Uniprot
20	S	Phosphorylation	Kinase	DAPK1	Q80YE7	PSP
20	S	Phosphorylation	Kinase	DAPK3	O54784	Uniprot
20	S	Phosphorylation	Kinase	PAK4	Q8BTW9	PSP
20	S	Phosphorylation	Kinase	ROCK2	P70336	PSP
20	S	Phosphorylation	Kinase	MLCK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ML12B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ML12B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ML12B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.