dbPTM

PYGL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYGL_MOUSE
UniProt AC	Q9ET01
Protein Name	Glycogen phosphorylase, liver form
Gene Name	Pygl
Organism	Mus musculus (Mouse).
Sequence Length	850
Subcellular Localization
Protein Description	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)..
Protein Sequence	MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTQTGTKWVDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGMGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWAKAWEITKKTFAYTNHTVLPEALERWPVELVEKLLPRHLEIIYEINQKHLDRIVALFPKDISRMRRMSLIEEEGGKRINMAHLCIVGCHAVNGVAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLADLIAEKIGEDYVKDLSQLTKLHSFVSDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVITMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLITSVAEVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEAYVKCQEKVSQLYMNQKAWNTMVLKNIAASGKFSSDRTIKEYAKDIWNMEPSDLKISLSNESSNGVSANGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKPLTDQE ------CCCCCCHHH	23.36	-
3	Acetylation	-----MAKPLTDQEK -----CCCCCCHHHH	38.98	6566199
3	Malonylation	-----MAKPLTDQEK -----CCCCCCHHHH	38.98	26320211
3	Ubiquitination	-----MAKPLTDQEK -----CCCCCCHHHH	38.98	-
10	Succinylation	KPLTDQEKRRQISIR CCCCHHHHHHCCCHH	47.44	23954790
15	Phosphorylation	QEKRRQISIRGIVGV HHHHHCCCHHHEECC	9.63	17257813
29	Acetylation	VENVAELKKGFNRHL CCCHHHHHCCCCCCE	42.21	23864654
29	Malonylation	VENVAELKKGFNRHL CCCHHHHHCCCCCCE	42.21	26320211
29	Ubiquitination	VENVAELKKGFNRHL CCCHHHHHCCCCCCE	42.21	27667366
30	Acetylation	ENVAELKKGFNRHLH CCHHHHHCCCCCCEE	79.81	23954790
30	Malonylation	ENVAELKKGFNRHLH CCHHHHHCCCCCCEE	79.81	25418362
42	Ubiquitination	HLHFTLVKDRNVATP CEEEEEECCCCCCCC	54.83	-
75	Phosphorylation	WIRTQQHYYDKCPKR HHHHCCHHHHCCCCC	14.71	-
76	Phosphorylation	IRTQQHYYDKCPKRV HHHCCHHHHCCCCCE	13.55	25195567
78	Acetylation	TQQHYYDKCPKRVYY HCCHHHHCCCCCEEE	35.99	22733758
78	Malonylation	TQQHYYDKCPKRVYY HCCHHHHCCCCCEEE	35.99	26320211
78	Ubiquitination	TQQHYYDKCPKRVYY HCCHHHHCCCCCEEE	35.99	-
156	Phosphorylation	ATLGLAAYGYGIRYE HHHHHHHHHCCCEEE	12.79	-
170	Acetylation	EYGIFNQKIREGWQV EEECCCHHHCCCCCE	44.85	66695399
170	Malonylation	EYGIFNQKIREGWQV EEECCCHHHCCCCCE	44.85	26320211
170	Ubiquitination	EYGIFNQKIREGWQV EEECCCHHHCCCCCE	44.85	27667366
204	Phosphorylation	FMLPVHFYGRVEHTQ CEEEEEEEEEEEECC	6.80	26032504
227	Phosphorylation	QVVLALPYDTPVPGY EEEEEECCCCCCCCC	33.04	-
277	Phosphorylation	RNLAENISRVLYPND HHHHHHHHCCCCCCC	28.11	20531401
290	Acetylation	NDNFFEGKELRLKQE CCCCCCCCCEECCCE	46.51	38026455
290	Malonylation	NDNFFEGKELRLKQE CCCCCCCCCEECCCE	46.51	26320211
290	Ubiquitination	NDNFFEGKELRLKQE CCCCCCCCCEECCCE	46.51	27667366
295	Ubiquitination	EGKELRLKQEYFVVA CCCCEECCCEEEEEE	34.35	22790023
320	Ubiquitination	KASKFGSKDGMGTVF HHHHHCCCCCCCCCC	59.69	22790023
359	Acetylation	RIFVDIEKLPWAKAW HHHCCHHHCCCHHHH	61.25	38026431
359	Malonylation	RIFVDIEKLPWAKAW HHHCCHHHCCCHHHH	61.25	26320211
359	Ubiquitination	RIFVDIEKLPWAKAW HHHCCHHHCCCHHHH	61.25	-
364	Acetylation	IEKLPWAKAWEITKK HHHCCCHHHHHHHCC	50.60	66698109
364	Succinylation	IEKLPWAKAWEITKK HHHCCCHHHHHHHCC	50.60	-
364	Succinylation	IEKLPWAKAWEITKK HHHCCCHHHHHHHCC	50.60	23806337
364	Ubiquitination	IEKLPWAKAWEITKK HHHCCCHHHHHHHCC	50.60	-
370	Malonylation	AKAWEITKKTFAYTN HHHHHHHCCCEEECC	56.32	26320211
370	Ubiquitination	AKAWEITKKTFAYTN HHHHHHHCCCEEECC	56.32	22790023
371	Malonylation	KAWEITKKTFAYTNH HHHHHHCCCEEECCC	39.98	26320211
371	Ubiquitination	KAWEITKKTFAYTNH HHHHHHCCCEEECCC	39.98	27667366
395	Acetylation	WPVELVEKLLPRHLE CCHHHHHHHHHHHHH	48.09	66695283
395	Ubiquitination	WPVELVEKLLPRHLE CCHHHHHHHHHHHHH	48.09	22790023
410	Acetylation	IIYEINQKHLDRIVA HHHHHCHHHHHHHHH	41.46	66700179
410	Malonylation	IIYEINQKHLDRIVA HHHHHCHHHHHHHHH	41.46	26320211
410	Ubiquitination	IIYEINQKHLDRIVA HHHHHCHHHHHHHHH	41.46	-
421	Acetylation	RIVALFPKDISRMRR HHHHHCHHHHHHHHH	61.43	66696493
421	Malonylation	RIVALFPKDISRMRR HHHHHCHHHHHHHHH	61.43	26320211
421	Ubiquitination	RIVALFPKDISRMRR HHHHHCHHHHHHHHH	61.43	27667366
430	Phosphorylation	ISRMRRMSLIEEEGG HHHHHHHHHHHCCCC	25.12	22324799
438	Acetylation	LIEEEGGKRINMAHL HHHCCCCCEEEHHHE	62.05	7744587
438	Ubiquitination	LIEEEGGKRINMAHL HHHCCCCCEEEHHHE	62.05	22790023
446	S-nitrosylation	RINMAHLCIVGCHAV EEEHHHEEHHHHHHH	1.37	22178444
450	S-nitrosylation	AHLCIVGCHAVNGVA HHEEHHHHHHHCCCH	0.98	22178444
465	Acetylation	KIHSDIVKTQVFKDF HHCCHHHHHHCCCCH	33.31	66697495
465	Malonylation	KIHSDIVKTQVFKDF HHCCHHHHHHCCCCH	33.31	26320211
465	Ubiquitination	KIHSDIVKTQVFKDF HHCCHHHHHHCCCCH	33.31	27667366
470	Acetylation	IVKTQVFKDFSELEP HHHHHCCCCHHHCCC	60.03	28643137
470	Malonylation	IVKTQVFKDFSELEP HHHHHCCCCHHHCCC	60.03	26320211
470	Ubiquitination	IVKTQVFKDFSELEP HHHHHCCCCHHHCCC	60.03	27667366
473	Phosphorylation	TQVFKDFSELEPDKF HHCCCCHHHCCCHHH	51.94	23984901
479	Acetylation	FSELEPDKFQNKTNG HHHCCCHHHCCCCCC	60.61	66692015
479	Ubiquitination	FSELEPDKFQNKTNG HHHCCCHHHCCCCCC	60.61	22790023
483	Ubiquitination	EPDKFQNKTNGITPR CCHHHCCCCCCCCHH	32.36	22790023
496	S-palmitoylation	PRRWLLLCNPGLADL HHHHHHHCCCCHHHH	6.11	28526873
514	Acetylation	KIGEDYVKDLSQLTK HHCHHHHHCHHHHHH	46.88	66694639
514	Ubiquitination	KIGEDYVKDLSQLTK HHCHHHHHCHHHHHH	46.88	22790023
521	Acetylation	KDLSQLTKLHSFVSD HCHHHHHHHHHHHCC	53.44	66697089
521	Ubiquitination	KDLSQLTKLHSFVSD HCHHHHHHHHHHHCC	53.44	22790023
524	Phosphorylation	SQLTKLHSFVSDDIF HHHHHHHHHHCCHHH	37.47	26487105
527	Phosphorylation	TKLHSFVSDDIFLRE HHHHHHHCCHHHHHH	27.79	29899451
545	Ubiquitination	VKQENKLKFSQFLEK HHHHCCCCHHHHHHH	44.58	22790023
552	Acetylation	KFSQFLEKEYKVKIN CHHHHHHHHHCCCCC	69.37	66692875
552	Malonylation	KFSQFLEKEYKVKIN CHHHHHHHHHCCCCC	69.37	26320211
552	Ubiquitination	KFSQFLEKEYKVKIN CHHHHHHHHHCCCCC	69.37	27667366
557	Malonylation	LEKEYKVKINPSSMF HHHHHCCCCCHHHHC	32.39	26320211
557	Ubiquitination	LEKEYKVKINPSSMF HHHHHCCCCCHHHHC	32.39	-
561	Phosphorylation	YKVKINPSSMFDVHV HCCCCCHHHHCEEEH	29.91	22324799
562	Phosphorylation	KVKINPSSMFDVHVK CCCCCHHHHCEEEHH	25.40	23140645
574	Phosphorylation	HVKRIHEYKRQLLNC EHHHHHHHHHHHHHH	9.41	29899451
575	Acetylation	VKRIHEYKRQLLNCL HHHHHHHHHHHHHHH	30.59	7822991
581	S-palmitoylation	YKRQLLNCLHVITMY HHHHHHHHHHHHHHH	2.54	26165157
586	Phosphorylation	LNCLHVITMYNRIKK HHHHHHHHHHHHHCC	16.71	22817900
588	Phosphorylation	CLHVITMYNRIKKDP HHHHHHHHHHHCCCC	7.82	22817900
597	Malonylation	RIKKDPKKFFVPRTV HHCCCCHHCEECCEE	49.80	25418362
597	Ubiquitination	RIKKDPKKFFVPRTV HHCCCCHHCEECCEE	49.80	27667366
602	Dimethylation	PKKFFVPRTVIIGGK CHHCEECCEEEECCC	36.00	-
602	Methylation	PKKFFVPRTVIIGGK CHHCEECCEEEECCC	36.00	18965223
609	Ubiquitination	RTVIIGGKAAPGYHM CEEEECCCCCCCHHH	35.84	22790023
614	Phosphorylation	GGKAAPGYHMAKMII CCCCCCCHHHHHHHH	6.33	28464351
618	Ubiquitination	APGYHMAKMIIKLIT CCCHHHHHHHHHHHH	24.05	22790023
639	Phosphorylation	NNDPMVGSKLKVIFL CCCCCCCCEEEEEEE	24.33	25521595
640	Acetylation	NDPMVGSKLKVIFLE CCCCCCCEEEEEEEE	46.53	51084513
640	Malonylation	NDPMVGSKLKVIFLE CCCCCCCEEEEEEEE	46.53	26320211
640	Ubiquitination	NDPMVGSKLKVIFLE CCCCCCCEEEEEEEE	46.53	-
642	Ubiquitination	PMVGSKLKVIFLENY CCCCCEEEEEEEECC	36.70	22790023
656	Ubiquitination	YRVSLAEKVIPATDL CCHHHHHHEEECCCH	39.60	22790023
681	N6-(pyridoxal phosphate)lysine	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
681	Other	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
724	Acetylation	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	15618597
724	Malonylation	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	26320211
724	Ubiquitination	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	27667366
730	Acetylation	DKKGYEAKEYYEALP CCCCCCHHHHHHHCH	34.02	38026419
730	Malonylation	DKKGYEAKEYYEALP CCCCCCHHHHHHHCH	34.02	26320211
730	Ubiquitination	DKKGYEAKEYYEALP CCCCCCHHHHHHHCH	34.02	-
773	Ubiquitination	LFYHDRFKVFADYEA HHHCHHHHEECCHHH	37.02	22790023
783	Malonylation	ADYEAYVKCQEKVSQ CCHHHHHHHHHHHHH	19.95	26320211
787	Malonylation	AYVKCQEKVSQLYMN HHHHHHHHHHHHHHC	22.70	26320211
796	Acetylation	SQLYMNQKAWNTMVL HHHHHCHHHHHHHHH	50.82	46007433
796	Ubiquitination	SQLYMNQKAWNTMVL HHHHHCHHHHHHHHH	50.82	22790023
804	Acetylation	AWNTMVLKNIAASGK HHHHHHHHHHHHCCC	34.59	38026407
804	Malonylation	AWNTMVLKNIAASGK HHHHHHHHHHHHCCC	34.59	26320211
804	Ubiquitination	AWNTMVLKNIAASGK HHHHHHHHHHHHCCC	34.59	27667366
809	Phosphorylation	VLKNIAASGKFSSDR HHHHHHHCCCCCCCH	33.23	24759943
811	Acetylation	KNIAASGKFSSDRTI HHHHHCCCCCCCHHH	39.31	66701303
811	Ubiquitination	KNIAASGKFSSDRTI HHHHHCCCCCCCHHH	39.31	22790023
813	Phosphorylation	IAASGKFSSDRTIKE HHHCCCCCCCHHHHH	34.51	25195567
817	Phosphorylation	GKFSSDRTIKEYAKD CCCCCCHHHHHHHHH	41.20	25195567
819	Malonylation	FSSDRTIKEYAKDIW CCCCHHHHHHHHHHH	44.02	26320211
823	Acetylation	RTIKEYAKDIWNMEP HHHHHHHHHHHCCCH	49.17	66698603
823	Malonylation	RTIKEYAKDIWNMEP HHHHHHHHHHHCCCH	49.17	26320211
823	Ubiquitination	RTIKEYAKDIWNMEP HHHHHHHHHHHCCCH	49.17	-
850	Acetylation	NGVSANGK------- CCCCCCCC-------	57.90	7744597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	S	Phosphorylation	Kinase	PHK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	S	Phosphorylation		-
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYGL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PYGL_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYGL_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527, AND MASSSPECTROMETRY.	17242355 [Abstract]

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