NDUA4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUA4_MOUSE
• UniProt AC: Q62425
• Protein Name: Cytochrome c oxidase subunit NDUFA4
• Gene Name: Ndufa4
• Organism: Mus musculus (Mouse).
• Sequence Length: 82
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity)..
• Protein Sequence: MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Succinylation	RQILGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	23954790
10	Ubiquitination	RQILGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	27667366
10	Acetylation	RQILGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	23576753
44	Phosphorylation	ALFNPDVSWDRKNNP HHHCCCCCCCCCCCC	30.55	21082442
48	Malonylation	PDVSWDRKNNPEPWN CCCCCCCCCCCCCHH	59.61	26320211
48	Ubiquitination	PDVSWDRKNNPEPWN CCCCCCCCCCCCCHH	59.61	27667366
56	Acetylation	NNPEPWNKLGPNEQY CCCCCHHHCCCCCCE	51.45	23954790
56	Ubiquitination	NNPEPWNKLGPNEQY CCCCCHHHCCCCCCE	51.45	22790023
63	Phosphorylation	KLGPNEQYKFYSVNV HCCCCCCEEEEEEEC	9.26	25195567
64	Ubiquitination	LGPNEQYKFYSVNVD CCCCCCEEEEEEECC	37.20	27667366
64	Acetylation	LGPNEQYKFYSVNVD CCCCCCEEEEEEECC	37.20	21728379
64	Succinylation	LGPNEQYKFYSVNVD CCCCCCEEEEEEECC	37.20	26388266
66	Phosphorylation	PNEQYKFYSVNVDYS CCCCEEEEEEECCHH	13.93	25195567
67	Phosphorylation	NEQYKFYSVNVDYSK CCCEEEEEEECCHHH	15.45	26643407
72	Phosphorylation	FYSVNVDYSKLKKEG EEEEECCHHHHHHCC	11.92	29514104
73	Phosphorylation	YSVNVDYSKLKKEGP EEEECCHHHHHHCCC	27.35	28542873
74	Ubiquitination	SVNVDYSKLKKEGPD EEECCHHHHHHCCCC	59.08	27667366
74	Acetylation	SVNVDYSKLKKEGPD EEECCHHHHHHCCCC	59.08	23864654
74	Malonylation	SVNVDYSKLKKEGPD EEECCHHHHHHCCCC	59.08	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUA4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUA4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUA4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUA4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56, AND MASS SPECTROMETRY.
PubMed: 16916647