ZDH13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDH13_MOUSE
• UniProt AC: Q9CWU2
• Protein Name: Palmitoyltransferase ZDHHC13 {ECO:0000305}
• Gene Name: Zdhhc13 {ECO:0000312|MGI:MGI:1919227}
• Organism: Mus musculus (Mouse).
• Sequence Length: 622
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles.
• Protein Description: Palmitoyltransferase for HTT and GAD2. [PubMed: 19299482 May play a role in Mg(2+) transport]
• Protein Sequence: MEGPGLGSQCRNHSHGSHVPGFGRHGICVHENKELAKAKEILPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDRENVSLLHWAAINNRLELVKFYISKGAVIDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHKCELFLLLILSMITLWAVGYILDFNSDSWLLKGCLLVALFFLTSLFPRFLVGYKNLVYLPTVFLLSSIFWIFMTWFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTWATDPGFTKASEEERKVNIVTLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNLGFTQNLADFFQCGCFGLVKPCIIDWTSQYTMVFHPAKEKVLRSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGPGLGS -------CCCCCCCH	14.00	-
59	Phosphorylation	DIVKATQYGIFERCK CHHHHHHHCHHHHHH	14.08	-
84	Phosphorylation	QPDRENVSLLHWAAI CCCCCCCEEHHHHHH	36.47	28059163
191	Phosphorylation	TPLMLSAYKVIGPEP CCEEEEEEEEECCCC	11.47	-
279	Acetylation	EAKMRANKQFRLWRW HHHHHHHHHHHHHHH	50.24	22902405
430	Ubiquitination	DFRTFCTSCLIRKPL CHHHHHHHHHHCCCC	14.22	27667366
560	Ubiquitination	HERISLLKQSRHMKQ HHHHHHHHHCHHHHH	52.07	27667366
562	Phosphorylation	RISLLKQSRHMKQTL HHHHHHHCHHHHHHH	23.67	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDH13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDH13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDH13_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.