FHOD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FHOD1_MOUSE
• UniProt AC: Q6P9Q4
• Protein Name: FH1/FH2 domain-containing protein 1
• Gene Name: Fhod1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1197
• Subcellular Localization: Cytoplasm. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, bleb. Predominantly cytoplasmic..
• Protein Description: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity)..
• Protein Sequence: MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIQAVNAVASATGTLPWANLVSILEEKNGADAELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRFLGTAGTDVDLRTQLTLYESALRLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRAPEPGSTGSASPVGSTPSTGSAPPTNPAFSSTGPASGLLRTSVNLFPTISVGPSVDSSCERSVYKARFLENVAAAETEKQAALAQGRAETLAGATVDDTDGSSGTRELWDSPEPASAPRTPQSPVSRILLRTQRSLEPEPKKPVSPPSPKAEPIQEPPTCVPKLCIGDLDFSDLGEDEDQDTLNVESVEAGKASPFLSSLSPSLSGGPPPPPPPPPPITGSCPPPPPPPLPPPATGSCPPPPPPPPPPIIGSCPPPPPLAAPFTHSALDGPRHPTKRKTVKLFWRELKLTGGPGCSRSRFGPCPTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTVVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAENFLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLYLGYTPQAARDVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVAGEAPNNLSVPVAVGSGPGQGDTDNHASMKSLLTSRPEDATHSRRSRGMVQSSSPVSHTAVGPSAASPEETAASGLPTDTSDEIMDLLVQSVTKSGPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	KPTLILRTQLSVRVN CCEEEEEECHHHHHH	30.34	22871156
117	Phosphorylation	LILRTQLSVRVNAIL EEEEECHHHHHHHHH	9.69	22871156
138	Phosphorylation	SGPELRRSLFSLKQI CCHHHHHHHHHHHHH	27.60	23737553
141	Phosphorylation	ELRRSLFSLKQIFQE HHHHHHHHHHHHHHH	39.69	23737553
360	Phosphorylation	RRERRKPSSEEGKRS CCCCCCCCCHHHHHH	54.11	25266776
361	Phosphorylation	RERRKPSSEEGKRSR CCCCCCCCHHHHHHH	48.47	26824392
368	Methylation	SEEGKRSRRSLEGGG CHHHHHHHHHHCCCC	35.92	-
370	Phosphorylation	EGKRSRRSLEGGGCP HHHHHHHHHCCCCCC	29.66	25521595
379	Methylation	EGGGCPVRAPEPGST CCCCCCCCCCCCCCC	29.57	-
385	Phosphorylation	VRAPEPGSTGSASPV CCCCCCCCCCCCCCC	40.07	25777480
386	Phosphorylation	RAPEPGSTGSASPVG CCCCCCCCCCCCCCC	40.86	25777480
388	Phosphorylation	PEPGSTGSASPVGST CCCCCCCCCCCCCCC	26.17	25777480
390	Phosphorylation	PGSTGSASPVGSTPS CCCCCCCCCCCCCCC	23.09	24453211
394	Phosphorylation	GSASPVGSTPSTGSA CCCCCCCCCCCCCCC	37.06	25777480
395	Phosphorylation	SASPVGSTPSTGSAP CCCCCCCCCCCCCCC	18.48	25777480
397	Phosphorylation	SPVGSTPSTGSAPPT CCCCCCCCCCCCCCC	45.55	25777480
398	Phosphorylation	PVGSTPSTGSAPPTN CCCCCCCCCCCCCCC	36.04	25777480
400	Phosphorylation	GSTPSTGSAPPTNPA CCCCCCCCCCCCCCC	37.38	24453211
404	Phosphorylation	STGSAPPTNPAFSST CCCCCCCCCCCCCCC	53.42	25777480
409	Phosphorylation	PPTNPAFSSTGPASG CCCCCCCCCCCCCCH	29.15	25777480
410	Phosphorylation	PTNPAFSSTGPASGL CCCCCCCCCCCCCHH	30.81	25777480
411	Phosphorylation	TNPAFSSTGPASGLL CCCCCCCCCCCCHHC	46.09	25777480
415	Phosphorylation	FSSTGPASGLLRTSV CCCCCCCCHHCCCEE	32.86	25777480
481	Phosphorylation	TVDDTDGSSGTRELW EECCCCCCCCCCCCC	28.53	22802335
482	Phosphorylation	VDDTDGSSGTRELWD ECCCCCCCCCCCCCC	50.11	22802335
484	Phosphorylation	DTDGSSGTRELWDSP CCCCCCCCCCCCCCC	23.95	22802335
490	Phosphorylation	GTRELWDSPEPASAP CCCCCCCCCCCCCCC	21.41	26643407
495	Phosphorylation	WDSPEPASAPRTPQS CCCCCCCCCCCCCCC	49.90	27087446
499	Phosphorylation	EPASAPRTPQSPVSR CCCCCCCCCCCHHHH	25.31	27087446
502	Phosphorylation	SAPRTPQSPVSRILL CCCCCCCCHHHHHHH	28.59	25521595
505	Phosphorylation	RTPQSPVSRILLRTQ CCCCCHHHHHHHHCC	19.58	26745281
511	Phosphorylation	VSRILLRTQRSLEPE HHHHHHHCCCCCCCC	28.44	25338131
514	Phosphorylation	ILLRTQRSLEPEPKK HHHHCCCCCCCCCCC	27.54	26824392
524	Phosphorylation	PEPKKPVSPPSPKAE CCCCCCCCCCCCCCC	39.35	27087446
527	Phosphorylation	KKPVSPPSPKAEPIQ CCCCCCCCCCCCCCC	42.28	27087446
538	Phosphorylation	EPIQEPPTCVPKLCI CCCCCCCCCCCCEEE	36.53	25777480
551	Phosphorylation	CIGDLDFSDLGEDED EECCCCHHHCCCCCC	31.43	23608596
722	Phosphorylation	KAGEGRRTMTVVLDP CCCCCCCEEEEEECC	18.81	-
936	Glutathionylation	ENLGQLECRSQAAED HHHCHHHHHHHHHHH	7.44	24333276
1097	Phosphorylation	TSRPEDATHSRRSRG HCCCCCCCCCCHHCC	32.48	29176673
1099	Phosphorylation	RPEDATHSRRSRGMV CCCCCCCCCHHCCCC	25.65	29176673
1108	Phosphorylation	RSRGMVQSSSPVSHT HHCCCCCCCCCCCCC	22.75	25338131
1113	Phosphorylation	VQSSSPVSHTAVGPS CCCCCCCCCCCCCCC	20.64	23649490
1115	Phosphorylation	SSSPVSHTAVGPSAA CCCCCCCCCCCCCCC	18.61	21659605
1120	Phosphorylation	SHTAVGPSAASPEET CCCCCCCCCCCHHHH	30.45	23649490
1130	Phosphorylation	SPEETAASGLPTDTS CHHHHHHCCCCCCCH	38.10	23649490
1137	Phosphorylation	SGLPTDTSDEIMDLL CCCCCCCHHHHHHHH	35.74	23649490
1170	Phosphorylation	RSRGNRKSLRRTLKS HHHCCHHHHHHHHHH	24.70	22817900
1174	Phosphorylation	NRKSLRRTLKSGLGD CHHHHHHHHHHCCCH	31.91	21106951

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1174	T	Phosphorylation	Kinase	ROCK1	P70335	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FHOD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FHOD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FHOD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.