MED14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED14_MOUSE
• UniProt AC: A2ABV5
• Protein Name: Mediator of RNA polymerase II transcription subunit 14
• Gene Name: Med14
• Organism: Mus musculus (Mouse).
• Sequence Length: 1459
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
402	Phosphorylation	AMKIDHLSIEKLLID HHHCCCCCHHHHHHH	25.86	28059163
410	Phosphorylation	IEKLLIDSVHARAHQ HHHHHHHHHHHHHHH	14.60	28059163
606	Phosphorylation	DNIQDLMSYTKTGKQ HHHHHHHHHHCCCCC	36.63	25159016
607	Phosphorylation	NIQDLMSYTKTGKQT HHHHHHHHHCCCCCC	9.78	25159016
623	Phosphorylation	TGTKHKLSDDPCPID CCCCCCCCCCCCCCC	44.78	-
868	Phosphorylation	LQEMFNKTPNVVQLL HHHHHHCCCCHHHHH	22.62	20469934
881	Phosphorylation	LLQVLFDTQAPLNAI HHHHHHCCCCCHHHH	21.21	20469934
893	Phosphorylation	NAINKLPTVPMLGLT HHHHCCCCCCCCCEE	47.91	20469934
900	Phosphorylation	TVPMLGLTQRTNTAY CCCCCCEECCCCCHH	17.76	20469934
983	Phosphorylation	NQDARRRSVNEDDNP CHHHHHHCCCCCCCC	27.73	27087446
992	Phosphorylation	NEDDNPPSPIGGDMM CCCCCCCCCCCHHHH	30.33	27180971
1001	Phosphorylation	IGGDMMDSLISQLQP CCHHHHHHHHHHCCC	15.09	26643407
1004	Phosphorylation	DMMDSLISQLQPPQQ HHHHHHHHHCCCCCC	30.08	26745281
1106	Phosphorylation	SSPYTMVSPSGRAGN CCCCEEECCCCCCCC	11.52	25338131
1117	Phosphorylation	RAGNWPGSPQVSGPS CCCCCCCCCCCCCCC	14.21	22942356
1121	Phosphorylation	WPGSPQVSGPSPATR CCCCCCCCCCCCCCC	39.47	25777480
1124	Phosphorylation	SPQVSGPSPATRLPG CCCCCCCCCCCCCCC	30.60	21082442
1127	Phosphorylation	VSGPSPATRLPGMSP CCCCCCCCCCCCCCC	35.80	26643407
1133	Phosphorylation	ATRLPGMSPANPSLH CCCCCCCCCCCCCCC	27.12	26824392
1138	Phosphorylation	GMSPANPSLHSPVPD CCCCCCCCCCCCCCC	38.22	21082442
1141	Phosphorylation	PANPSLHSPVPDVSH CCCCCCCCCCCCCCC	32.65	26824392
1147	Phosphorylation	HSPVPDVSHSPRAGT CCCCCCCCCCCCCCC	26.15	26824392
1149	Phosphorylation	PVPDVSHSPRAGTSS CCCCCCCCCCCCCCC	14.47	26824392
1412	Phosphorylation	DIPRQQNSSVAAPMM CCCCCCCCCCHHHHH	23.11	26745281
1413	Phosphorylation	IPRQQNSSVAAPMMV CCCCCCCCCHHHHHH	24.27	26745281
1421	Phosphorylation	VAAPMMVSNILKRFA CHHHHHHHHHHHHHH	10.56	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.