dbPTM

RGPA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGPA2_MOUSE
UniProt AC	A3KGS3
Protein Name	Ral GTPase-activating protein subunit alpha-2
Gene Name	Ralgapa2
Organism	Mus musculus (Mouse).
Sequence Length	1872
Subcellular Localization	Cytoplasm.
Protein Description	Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB..
Protein Sequence	MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDASDLKQFFETNYSQIYFIFYENFITLENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVLSSRGPCTLETLINPSPSIVDAKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLEIPHLRPKPVYVTVTRDNETIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAIQEKVPELDGAGSTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRTVYEMVQRILLSTRGYVNFVNEVFRQAFLLPSCEISVTRKVVQVYRKWILQNKPVFMEEPDKKDVAQEDADKLGLSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEDNTNVKAGAQAMLQVFLTNAANVFLLEPCAEVPMLLREQVDASKAVLIIFRRMIMELTMNQKTWEQMLQILLRITEAVMQKPKDKHVKDLFAQSLAGLLFRTLIVAWIRANLCVYISRELWDDFLRVLSSLTEWEELITEWSNIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCILEPQKGTAVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNTVRQKATEVEEFQQAESTAAADCDYLVVGQQQVPRSSSTSDITERLYSDSSQGQKVEHSQNLSSSEPKSVQESKGHVTHEHEGITMLVRRSSSPAELELKDDLQQAHGRCRQRQTSESTGSDTVVGYSNEAELPVSPWQACEEDPDLSTPTDAVADSDARHWLQLSPTDASNLTDSRECLADDCSIIAGGNLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHAKVFGYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPPLRMFASWLFKATTLPNEYKEGKLQAYKLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVLNTIIKNCSPRFFSLGLPGFSMLVGDFITAAARVLSTDMLAAPRSEALTLLGSLVCFPNTYQEIPLLQSVPEVSDVVTGAEDVKHYLINILLKNATEEPNECARCIAICSLGVWICEELAQSASHPQVKDAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSALLHPVSTAVLEELHPSRAPLLDYIYRVLHCCVCGSSTYTQQSHYTLTLADLSSTDYDPFLPLANVRNSEPIQYHSSADLGNLLTVEEEKKRRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHDNAHVEGTELSSEVFRSPNLQLFVFNDSTLISYLQTPAEGPAGGTSGGSLSDVRVIVRDISGKYSWDGKVLYGPLEGRLAPNGRNPSFQISGWHHHTCGPQKDLFNGEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSPTPCAMNWDQEKAIMEVILRQSAQEDEYVQRCNSDSSVTVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFITITKKPEVPFFGPLFDGAIVSGKLLPSLICATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSVSGTD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
318	Phosphorylation	FLEKKYLTATQNTKN HHHHHCCCCCCCCCC	25.27	-
354	Phosphorylation	PELDGAGSTEQDKSH CCCCCCCCCCCCCCC	28.39	25293948
355	Phosphorylation	ELDGAGSTEQDKSHS CCCCCCCCCCCCCCC	36.43	25293948
360	Phosphorylation	GSTEQDKSHSNSSTL CCCCCCCCCCCCCCH	40.20	25293948
362	Phosphorylation	TEQDKSHSNSSTLSD CCCCCCCCCCCCHHH	45.56	27681418
364	Phosphorylation	QDKSHSNSSTLSDRR CCCCCCCCCCHHHHH	27.93	25293948
365	Phosphorylation	DKSHSNSSTLSDRRL CCCCCCCCCHHHHHC	37.30	27681418
366	Phosphorylation	KSHSNSSTLSDRRLS CCCCCCCCHHHHHCC	30.06	27681418
368	Phosphorylation	HSNSSTLSDRRLSNS CCCCCCHHHHHCCCC	29.20	27681418
373	Phosphorylation	TLSDRRLSNSSLCSI CHHHHHCCCCCCCCH	32.62	25521595
375	Phosphorylation	SDRRLSNSSLCSIEE HHHHCCCCCCCCHHH	22.70	27087446
376	Phosphorylation	DRRLSNSSLCSIEEE HHHCCCCCCCCHHHH	37.33	25521595
379	Phosphorylation	LSNSSLCSIEEEHRT CCCCCCCCHHHHHHH	38.02	25521595
478	Phosphorylation	ESSGHKRSSSWGRTY CCCCCCCCCCCCCCE	33.26	30387612
480	Phosphorylation	SGHKRSSSWGRTYSF CCCCCCCCCCCCEEC	34.49	23737553
484	Phosphorylation	RSSSWGRTYSFTSAM CCCCCCCCEECCCCH	21.41	26745281
485	Phosphorylation	SSSWGRTYSFTSAMS CCCCCCCEECCCCHH	10.63	23140645
486	Phosphorylation	SSWGRTYSFTSAMSR CCCCCCEECCCCHHC	22.80	25521595
488	Phosphorylation	WGRTYSFTSAMSRGC CCCCEECCCCHHCCC	15.05	26745281
489	Phosphorylation	GRTYSFTSAMSRGCV CCCEECCCCHHCCCC	21.69	26745281
492	Phosphorylation	YSFTSAMSRGCVTEE EECCCCHHCCCCCCC	25.82	28066266
580	Acetylation	ITEAVMQKPKDKHVK HHHHHHCCCCCHHHH	35.62	66694561
582	Acetylation	EAVMQKPKDKHVKDL HHHHCCCCCHHHHHH	83.13	66694567
694	Phosphorylation	KGTAVGRSFSLSWRS CCCCCCCCEEEEECC	17.17	26745281
696	Phosphorylation	TAVGRSFSLSWRSHP CCCCCCEEEEECCCC	23.81	22942356
698	Phosphorylation	VGRSFSLSWRSHPDV CCCCEEEEECCCCCC	21.17	28066266
701	Phosphorylation	SFSLSWRSHPDVTEP CEEEEECCCCCCCCC	32.87	23684622
713	Phosphorylation	TEPMRFRSATTSGAP CCCCEECCCCCCCCC	27.53	29550500
715	Phosphorylation	PMRFRSATTSGAPGV CCEECCCCCCCCCCH	23.81	26824392
716	Phosphorylation	MRFRSATTSGAPGVE CEECCCCCCCCCCHH	25.53	23737553
763	Phosphorylation	GQQQVPRSSSTSDIT CCCCCCCCCCCCHHH	23.67	28609623
764	Phosphorylation	QQQVPRSSSTSDITE CCCCCCCCCCCHHHH	38.63	28609623
765	Phosphorylation	QQVPRSSSTSDITER CCCCCCCCCCHHHHH	32.93	25521595
766	Phosphorylation	QVPRSSSTSDITERL CCCCCCCCCHHHHHH	32.16	28609623
767	Phosphorylation	VPRSSSTSDITERLY CCCCCCCCHHHHHHH	29.03	28609623
770	Phosphorylation	SSSTSDITERLYSDS CCCCCHHHHHHHCCC	21.75	18846507
792	Phosphorylation	HSQNLSSSEPKSVQE CCCCCCCCCCCCHHH	55.32	-
818	Phosphorylation	ITMLVRRSSSPAELE EEEEEECCCCCCCEE	25.30	25521595
819	Phosphorylation	TMLVRRSSSPAELEL EEEEECCCCCCCEEC	38.23	25521595
820	Phosphorylation	MLVRRSSSPAELELK EEEECCCCCCCEECH	29.40	25521595
893	Phosphorylation	ARHWLQLSPTDASNL CCHHHCCCCCCHHHC	16.88	29472430
895	Phosphorylation	HWLQLSPTDASNLTD HHHCCCCCCHHHCCC	40.60	23984901
898	Phosphorylation	QLSPTDASNLTDSRE CCCCCCHHHCCCCCH	34.87	23984901
901	Phosphorylation	PTDASNLTDSRECLA CCCHHHCCCCCHHHC	35.86	23737553
903	Phosphorylation	DASNLTDSRECLADD CHHHCCCCCHHHCCC	25.41	23737553
974	Phosphorylation	IRDNLAISLDNQSSP HHHCEEEECCCCCCC	24.86	25293948
979	Phosphorylation	AISLDNQSSPSPPLL EEECCCCCCCCCCCC	50.93	25293948
980	Phosphorylation	ISLDNQSSPSPPLLI EECCCCCCCCCCCCC	21.45	25293948
982	Phosphorylation	LDNQSSPSPPLLIPP CCCCCCCCCCCCCHH	40.89	25293948
1346	Phosphorylation	RNSEPIQYHSSADLG CCCCCCEECCCCCCC	12.37	23984901
1348	Phosphorylation	SEPIQYHSSADLGNL CCCCEECCCCCCCCC	23.45	19060867
1349	Phosphorylation	EPIQYHSSADLGNLL CCCEECCCCCCCCCC	16.70	23984901
1357	Phosphorylation	ADLGNLLTVEEEKKR CCCCCCCCHHHHHHH	29.10	21082442
1366	Phosphorylation	EEEKKRRSVELIPLT HHHHHHCCCCHHHHH	24.79	24759943
1592	Phosphorylation	VTSQGQPSPVEPRGP EEECCCCCCCCCCCC	33.42	30635358
1721	Phosphorylation	VEVIFHVSTRMPSDS EEEEEEEECCCCCCC	11.17	-
1722	Phosphorylation	EVIFHVSTRMPSDSD EEEEEEECCCCCCCC	29.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
696	S	Phosphorylation	Kinase	PKB	P31750	Uniprot
715	T	Phosphorylation	Kinase	PKB	P31750	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RGPA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGPA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RGPA2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGPA2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-819 AND SER-820, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376; SER-379;SER-819 AND SER-820, AND MASS SPECTROMETRY.	17242355 [Abstract]