ZC3HE_MOUSE - dbPTM
ZC3HE_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZC3HE_MOUSE
UniProt AC Q8BJ05
Protein Name Zinc finger CCCH domain-containing protein 14
Gene Name Zc3h14
Organism Mus musculus (Mouse).
Sequence Length 735
Subcellular Localization Nucleus speckle . Colocalizes with poly(A) RNA in nuclear speckles.
Protein Description Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides..
Protein Sequence MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDASIFDSHVPSNKSSFSRGDERRHEAAVPPLAVSSSRPEKRDSRVSTSSQEQKSTNVRHSYDDGASTRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADTGTHLNRLQLHPQQSSAHAAKQLDVQSSQVSEAGRLCEPPVLSSVEDTYSPFFRNNLDKMSIEDENFRKRKLPVVSSVVKVKRFSHDGEEEEEDEDYGTRIGSLSSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSAVPQKQTLPVAPRTRTSQEELLAEMVQGQNRAPRISPPVKEEEAKGDNTGKSQGTQQRQLLSRLQIDPVMVETMEMSQDYYDMESMVHADTRSFILKKPKLSEEIVVTPNQDSGMKTADALRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFEGMKPVNQTSASNKGLRGLLHPQQLHLLSRQLEDPDGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKAFPNCKFAEKCLFVHPNCKYDTKCTKADCPFTHMSRRASILTPKPVSSPAPSSNGQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTITVPPRHALKWIRPQSSE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEIGTEIS
-------CCCHHHHH		8.37-
5Phosphorylation---MEIGTEISRKIR
---CCCHHHHHHHHH		35.4929895711
8PhosphorylationMEIGTEISRKIRSAI
CCCHHHHHHHHHHHH		22.6829895711
75PhosphorylationGVLDKLRSVTTEPSS
HHHHHHHHCCCCCHH		33.9625159016
77PhosphorylationLDKLRSVTTEPSSLK
HHHHHHCCCCCHHCC		27.0425159016
78PhosphorylationDKLRSVTTEPSSLKS
HHHHHCCCCCHHCCC		43.6825159016
81PhosphorylationRSVTTEPSSLKSPDA
HHCCCCCHHCCCCCC		41.9125159016
82PhosphorylationSVTTEPSSLKSPDAS
HCCCCCHHCCCCCCC		51.0025159016
85PhosphorylationTEPSSLKSPDASIFD
CCCHHCCCCCCCCCC		33.0525521595
89PhosphorylationSLKSPDASIFDSHVP
HCCCCCCCCCCCCCC		31.0425159016
93PhosphorylationPDASIFDSHVPSNKS
CCCCCCCCCCCCCCC		18.6825159016
97PhosphorylationIFDSHVPSNKSSFSR
CCCCCCCCCCCCCCC		56.6625338131
129PhosphorylationSRPEKRDSRVSTSSQ
CCCCCCCCCCCCCCC		38.3229550500
132PhosphorylationEKRDSRVSTSSQEQK
CCCCCCCCCCCCHHH		22.8225266776
133PhosphorylationKRDSRVSTSSQEQKS
CCCCCCCCCCCHHHH		29.5529550500
134PhosphorylationRDSRVSTSSQEQKST
CCCCCCCCCCHHHHC		23.6329550500
135PhosphorylationDSRVSTSSQEQKSTN
CCCCCCCCCHHHHCC		37.5125266776
146PhosphorylationKSTNVRHSYDDGAST
HHCCCCHHCCCCHHC		21.5030635358
147PhosphorylationSTNVRHSYDDGASTR
HCCCCHHCCCCHHCC		16.3621183079
152PhosphorylationHSYDDGASTRLMSTV
HHCCCCHHCCCCEEC		21.4230635358
153PhosphorylationSYDDGASTRLMSTVK
HCCCCHHCCCCEECC		27.5630635358
157PhosphorylationGASTRLMSTVKPLRE
CHHCCCCEECCCCCC		34.3421183079
175UbiquitinationSEDVIDIKPEPDDLI
CCCCCCCCCCCCCCC		39.31-
193UbiquitinationLNFVQENPLSQKKPT
CCCHHHCCCCCCCCE		32.4127667366
211PhosphorylationTYGSSRPSIEIYRPP
EECCCCCCEEEECCC		31.57-
240PhosphorylationQLHPQQSSAHAAKQL
CCCCCCCHHHHHHHC		21.53-
245AcetylationQSSAHAAKQLDVQSS
CCHHHHHHHCCCCHH		52.7822826441
245UbiquitinationQSSAHAAKQLDVQSS
CCHHHHHHHCCCCHH		52.78-
274PhosphorylationSSVEDTYSPFFRNNL
CCCCCCCCHHHHCCC		19.8126643407
283UbiquitinationFFRNNLDKMSIEDEN
HHHCCCHHCCCCCCC		37.40-
285PhosphorylationRNNLDKMSIEDENFR
HCCCHHCCCCCCCHH		28.6826370283
301PhosphorylationRKLPVVSSVVKVKRF
CCCCCEEEEEEEEEE		21.2221659605
309PhosphorylationVVKVKRFSHDGEEEE
EEEEEEECCCCCCCC		25.3825521595
314UbiquitinationRFSHDGEEEEEDEDY
EECCCCCCCCCCCCC		76.0027667366
327PhosphorylationDYGTRIGSLSSSVSV
CCCCCCCCCCCCCCC		23.7827600695
331PhosphorylationRIGSLSSSVSVPAKP
CCCCCCCCCCCCCCC		18.2922871156
337UbiquitinationSSVSVPAKPERRPSL
CCCCCCCCCCCCCCC		41.14-
343PhosphorylationAKPERRPSLPPSKQA
CCCCCCCCCCCCHHH		52.2626824392
347PhosphorylationRRPSLPPSKQANKNL
CCCCCCCCHHHCHHH		35.1529899451
348UbiquitinationRPSLPPSKQANKNLI
CCCCCCCHHHCHHHH		60.2427667366
357AcetylationANKNLILKAISEAQE
HCHHHHHHHHHHHHH		36.3622826441
360PhosphorylationNLILKAISEAQESVT
HHHHHHHHHHHHHHH		31.5729899451
368UbiquitinationEAQESVTKTTNYSAV
HHHHHHHHCCCCCCC		51.72-
378UbiquitinationNYSAVPQKQTLPVAP
CCCCCCCCCCCCCCC		38.90-
387PhosphorylationTLPVAPRTRTSQEEL
CCCCCCCCCCCHHHH		36.9228833060
389PhosphorylationPVAPRTRTSQEELLA
CCCCCCCCCHHHHHH		33.8628833060
390PhosphorylationVAPRTRTSQEELLAE
CCCCCCCCHHHHHHH		32.1025521595
409PhosphorylationQNRAPRISPPVKEEE
CCCCCCCCCCCCHHH		25.1626824392
418UbiquitinationPVKEEEAKGDNTGKS
CCCHHHHCCCCCCCC		70.81-
424UbiquitinationAKGDNTGKSQGTQQR
HCCCCCCCCHHHHHH		37.25-
435PhosphorylationTQQRQLLSRLQIDPV
HHHHHHHHHHCCCHH		39.27-
475PhosphorylationILKKPKLSEEIVVTP
HCCCCCCCCCEEECC		39.0322942356
481PhosphorylationLSEEIVVTPNQDSGM
CCCCEEECCCCCCCC		12.9622942356
486PhosphorylationVVTPNQDSGMKTADA
EECCCCCCCCCHHHH		30.9028066266
489UbiquitinationPNQDSGMKTADALRV
CCCCCCCCHHHHHHH		44.05-
498PhosphorylationADALRVLSGHLMQTR
HHHHHHHHHHHCCCC		22.70-
512UbiquitinationRDLVQPDKPASPKFI
CCCCCCCCCCCCCEE		49.52-
515PhosphorylationVQPDKPASPKFIVTL
CCCCCCCCCCEEEEE		36.8327087446
521PhosphorylationASPKFIVTLDGVPSP
CCCCEEEEECCCCCC		17.8323649490
527PhosphorylationVTLDGVPSPPGYMSD
EEECCCCCCCCCCCH		41.1226643407
531PhosphorylationGVPSPPGYMSDQEEE
CCCCCCCCCCHHHHH		10.1426643407
533PhosphorylationPSPPGYMSDQEEEMC
CCCCCCCCHHHHHHH		27.8826643407
550PhosphorylationGMKPVNQTSASNKGL
CCCCCCCCCCCCCCH		22.5126643407
551PhosphorylationMKPVNQTSASNKGLR
CCCCCCCCCCCCCHH		21.6726643407
553PhosphorylationPVNQTSASNKGLRGL
CCCCCCCCCCCHHHH		38.5526643407
620PhosphorylationCVYHHPISPCKAFPN
EEEECCCCCCCCCCC		28.7927087446
662PhosphorylationTHMSRRASILTPKPV
CCHHHCCCCCCCCCC		19.1329899451
665PhosphorylationSRRASILTPKPVSSP
HHCCCCCCCCCCCCC		27.8323984901
670PhosphorylationILTPKPVSSPAPSSN
CCCCCCCCCCCCCCC		38.8525263469
671PhosphorylationLTPKPVSSPAPSSNG
CCCCCCCCCCCCCCC		25.8930352176
675PhosphorylationPVSSPAPSSNGQLCR
CCCCCCCCCCCCCCH		38.2426745281
676PhosphorylationVSSPAPSSNGQLCRY
CCCCCCCCCCCCCHH		43.8724759943
683PhosphorylationSNGQLCRYFPACKKM
CCCCCCHHCCCCCCC		16.9621183079
733PhosphorylationLKWIRPQSSE-----
HHHHCCCCCC-----		38.8321183079
734PhosphorylationKWIRPQSSE------
HHHCCCCCC------		41.9221183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZC3HE_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZC3HE_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZC3HE_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZC3HE_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZC3HE_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, AND MASSSPECTROMETRY.

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