dbPTM

DHE3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHE3_MOUSE
UniProt AC	P26443
Protein Name	Glutamate dehydrogenase 1, mitochondrial
Gene Name	Glud1
Organism	Mus musculus (Mouse).
Sequence Length	558
Subcellular Localization	Mitochondrion matrix.
Protein Description	Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate..
Protein Sequence	MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPGLTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AGPAALGSAAADSAA CCHHHHCHHHHHHHH	18.65	22817900
68	Acetylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	23954790
68	Succinylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	-
68	Succinylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	23806337
79	Phosphorylation	GFFDRGASIVEDKLV CHHHCCCHHHHHHHH	29.95	25521595
84	Acetylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	23806337
84	Glutarylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	24703693
84	Malonylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	26320211
84	Succinylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	-
84	Succinylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	23806337
90	Acetylation	DKLVEDLKTRESEEQ HHHHHHHHCCCCHHH	58.83	23576753
90	Glutarylation	DKLVEDLKTRESEEQ HHHHHHHHCCCCHHH	58.83	24703693
90	Malonylation	DKLVEDLKTRESEEQ HHHHHHHHCCCCHHH	58.83	26073543
90	Succinylation	DKLVEDLKTRESEEQ HHHHHHHHCCCCHHH	58.83	-
90	Ubiquitination	DKLVEDLKTRESEEQ HHHHHHHHCCCCHHH	58.83	-
94	Phosphorylation	EDLKTRESEEQKRNR HHHHCCCCHHHHHHH	43.04	23140645
98	Acetylation	TRESEEQKRNRVRGI CCCCHHHHHHHHHHH	55.72	23864654
110	Acetylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	23576753
110	Succinylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	-
110	Succinylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	24315375
112	S-nitrosocysteine	ILRIIKPCNHVLSLS HHHHHHCCCEEEEEE	4.70	-
112	S-nitrosylation	ILRIIKPCNHVLSLS HHHHHHCCCEEEEEE	4.70	22178444
112	S-palmitoylation	ILRIIKPCNHVLSLS HHHHHHCCCEEEEEE	4.70	28526873
117	Phosphorylation	KPCNHVLSLSFPIRR HCCCEEEEEECEEEC	22.37	23140645
128	Phosphorylation	PIRRDDGSWEVIEGY EEECCCCCEEEEEEE	27.36	25521595
135	Phosphorylation	SWEVIEGYRAQHSQH CEEEEEEEECCCCCC	7.03	25619855
147	Acetylation	SQHRTPCKGGIRYST CCCCCCCCCCCCCCC	62.47	23806337
147	Malonylation	SQHRTPCKGGIRYST CCCCCCCCCCCCCCC	62.47	26320211
147	Succinylation	SQHRTPCKGGIRYST CCCCCCCCCCCCCCC	62.47	-
147	Ubiquitination	SQHRTPCKGGIRYST CCCCCCCCCCCCCCC	62.47	-
152	Phosphorylation	PCKGGIRYSTDVSVD CCCCCCCCCCCCCHH	17.63	23984901
153	Phosphorylation	CKGGIRYSTDVSVDE CCCCCCCCCCCCHHH	14.32	25521595
154	Phosphorylation	KGGIRYSTDVSVDEV CCCCCCCCCCCHHHH	31.33	23140645
157	Phosphorylation	IRYSTDVSVDEVKAL CCCCCCCCHHHHHHH	27.02	25521595
162	Acetylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	23576753
162	Succinylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	-
162	Succinylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	23806337
162	Ubiquitination	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	-
171	Acetylation	LASLMTYKCAVVDVP HHHHHHCEEEEEECC	13.42	23576753
171	Ubiquitination	LASLMTYKCAVVDVP HHHHHHCEEEEEECC	13.42	22790023
172	ADP-ribosylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	-
172	ADP-ribosylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	-
172	S-nitrosylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	22178444
172	S-palmitoylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	28526873
183	Acetylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	23806337
183	Succinylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	-
183	Succinylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	23806337
183	Ubiquitination	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	-
187	Acetylation	GGAKAGVKINPKNYT CCCCCCCCCCCCCCC	35.53	23576753
187	Malonylation	GGAKAGVKINPKNYT CCCCCCCCCCCCCCC	35.53	26320211
187	Succinylation	GGAKAGVKINPKNYT CCCCCCCCCCCCCCC	35.53	23806337
191	Acetylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	23576753
191	Malonylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	26320211
191	Succinylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	-
191	Succinylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	23806337
191	Ubiquitination	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	-
193	Phosphorylation	VKINPKNYTDNELEK CCCCCCCCCHHHHHH	22.92	25195567
200	Acetylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	23864654
200	Succinylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	-
200	Succinylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	23806337
200	Ubiquitination	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	-
211	Acetylation	RFTMELAKKGFIGPG HHHHHHHHCCCCCCC	67.08	23576753
211	Succinylation	RFTMELAKKGFIGPG HHHHHHHHCCCCCCC	67.08	23806337
212	Ubiquitination	FTMELAKKGFIGPGI HHHHHHHCCCCCCCC	54.14	22790023
226	Oxidation	IDVPAPDMSTGEREM CCCCCCCCCCCHHHH	3.63	17242355
227	Phosphorylation	DVPAPDMSTGEREMS CCCCCCCCCCHHHHH	40.41	22324799
228	Phosphorylation	VPAPDMSTGEREMSW CCCCCCCCCHHHHHH	36.10	22817900
254	S-nitrosylation	YDINAHACVTGKPIS CEECCCEEEECCCCC	1.70	22178444
261	Phosphorylation	CVTGKPISQGGIHGR EEECCCCCCCCCCCC	31.16	22324799
270	Phosphorylation	GGIHGRISATGRGVF CCCCCCCCCCCCCHH	20.58	29899451
272	Phosphorylation	IHGRISATGRGVFHG CCCCCCCCCCCHHHC	22.18	22324799
326	Acetylation	YLHRFGAKCVGVGES HHHHCCCEEEEECCC	29.81	23576753
326	Succinylation	YLHRFGAKCVGVGES HHHHCCCEEEEECCC	29.81	23806337
326	Ubiquitination	YLHRFGAKCVGVGES HHHHCCCEEEEECCC	29.81	-
327	S-nitrosocysteine	LHRFGAKCVGVGESD HHHCCCEEEEECCCC	2.97	-
327	S-nitrosylation	LHRFGAKCVGVGESD HHHCCCEEEEECCCC	2.97	24895380
333	Phosphorylation	KCVGVGESDGSIWNP EEEEECCCCCCCCCC	41.15	23984901
336	Phosphorylation	GVGESDGSIWNPDGI EECCCCCCCCCCCCC	29.44	23140645
346	Acetylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	23576753
346	Malonylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	26073543
346	Succinylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	-
346	Succinylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	23806337
352	Acetylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	23576753
352	Succinylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	-
352	Succinylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	23806337
352	Ubiquitination	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	-
357	Phosphorylation	DFKLQHGSILGFPKA HCCCCCCCCCCCCCC	16.71	23140645
363	Acetylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	23576753
363	Glutarylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	24703693
363	Succinylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	-
363	Succinylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	23806337
363	Ubiquitination	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	-
365	Acetylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	23576753
365	Succinylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	-
365	Succinylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	23806337
367	Phosphorylation	GFPKAKVYEGSILEA CCCCCEEECCCCEEE	17.54	23984901
370	Phosphorylation	KAKVYEGSILEADCD CCEEECCCCEEECCC	16.44	19060867
376	Glutathionylation	GSILEADCDILIPAA CCCEEECCCEEEECC	4.52	24333276
376	S-nitrosylation	GSILEADCDILIPAA CCCEEECCCEEEECC	4.52	22588120
384	Phosphorylation	DILIPAASEKQLTKS CEEEECCCHHHCCCC	47.64	23140645
386	Acetylation	LIPAASEKQLTKSNA EEECCCHHHCCCCCC	48.38	23864654
389	Phosphorylation	AASEKQLTKSNAPRV CCCHHHCCCCCCCHH	29.90	29550500
390	Acetylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	23576753
390	Glutarylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	24703693
390	Malonylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	26320211
390	Succinylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	-
390	Succinylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	23806337
391	Phosphorylation	SEKQLTKSNAPRVKA CHHHCCCCCCCHHEE	32.75	29550500
397	Acetylation	KSNAPRVKAKIIAEG CCCCCHHEEEEEECC	45.29	23201123
399	Acetylation	NAPRVKAKIIAEGAN CCCHHEEEEEECCCC	29.00	23576753
399	Glutarylation	NAPRVKAKIIAEGAN CCCHHEEEEEECCCC	29.00	24703693
399	Malonylation	NAPRVKAKIIAEGAN CCCHHEEEEEECCCC	29.00	26320211
399	Ubiquitination	NAPRVKAKIIAEGAN CCCHHEEEEEECCCC	29.00	-
409	Phosphorylation	AEGANGPTTPEADKI ECCCCCCCCHHHHHH	57.28	21082442
410	Phosphorylation	EGANGPTTPEADKIF CCCCCCCCHHHHHHH	23.43	25521595
415	Acetylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	23576753
415	Succinylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	-
415	Succinylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	23806337
415	Ubiquitination	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	-
444	Acetylation	VSYFEWLKNLNHVSY EEHHHHHHCCCCCEE	61.53	23576753
450	Phosphorylation	LKNLNHVSYGRLTFK HHCCCCCEEEEEEEE	17.83	26824392
451	Phosphorylation	KNLNHVSYGRLTFKY HCCCCCEEEEEEEEE	12.74	26032504
457	N6-malonyllysine	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
457	Acetylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	23576753
457	Malonylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	26320211
457	Succinylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
457	Ubiquitination	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
473	Phosphorylation	LLMSVQESLERKFGK EEEEHHHHHHHHHHC	20.59	22942356
477	Acetylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	23576753
477	Succinylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	-
477	Succinylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	23806337
477	Ubiquitination	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	-
480	Acetylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	23576753
480	Glutarylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	24703693
480	Malonylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	26320211
480	Succinylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	-
480	Succinylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	23806337
480	Ubiquitination	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	-
484	Phosphorylation	KFGKHGGTIPVVPTA HHHCCCCCCCCCCCH	27.05	-
490	Phosphorylation	GTIPVVPTAEFQDRI CCCCCCCCHHHHHHC	27.49	23140645
498	Phosphorylation	AEFQDRISGASEKDI HHHHHHCCCCCHHHH	29.24	23140645
501	Phosphorylation	QDRISGASEKDIVHS HHHCCCCCHHHHCHH	49.02	19060867
503	N6-malonyllysine	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	-
503	Acetylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	23806337
503	Glutarylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	24703693
503	Malonylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	26073543
503	Phosphoglycerylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	-
503	Succinylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	23806337
503	Ubiquitination	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	-
508	Phosphorylation	SEKDIVHSGLAYTME CHHHHCHHHHHHHHH	25.30	25521595
512	Phosphorylation	IVHSGLAYTMERSAR HCHHHHHHHHHHHHH	16.21	16873679
513	Phosphorylation	VHSGLAYTMERSARQ CHHHHHHHHHHHHHH	13.62	22817900
527	N6-malonyllysine	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	-
527	Acetylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	23806337
527	Glutarylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	24703693
527	Malonylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	26320211
527	Succinylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	23806337
528	Phosphorylation	IMRTAMKYNLGLDLR HHHHHHHHCCCCCHH	11.52	29514104
545	Acetylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	23806337
545	Glutarylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	24703693
545	Succinylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	-
545	Succinylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	23806337
545	Ubiquitination	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	-
548	Acetylation	NAIEKVFKVYNEAGV HHHHHHHHHHHHCCC	46.96	23576753
548	Succinylation	NAIEKVFKVYNEAGV HHHHHHHHHHHHCCC	46.96	24315375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DHE3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	K	Acetylation		23806337
Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHE3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DHE3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHE3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-135 AND TYR-512, ANDMASS SPECTROMETRY.	18034455 [Abstract]

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