RPB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPB2_MOUSE
• UniProt AC: Q8CFI7
• Protein Name: DNA-directed RNA polymerase II subunit RPB2
• Gene Name: Polr2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1174
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity)..
• Protein Sequence: MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYEKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	QAEAQHASGEVEEPP HHHHHHHCCCCCCCC	33.10	30635358
95	Ubiquitination	FEQIYLSKPTHWERD EEEEECCCCCCCCCC	51.87	22790023
130	Ubiquitination	PLYVDITKTVIKEGE CEEEEEEEHHHHHHH	40.92	22790023
146	Ubiquitination	QLQTQHQKTFIGKIP HHHHHHHHHHHCHHH	43.19	22790023
151	Ubiquitination	HQKTFIGKIPIMLRS HHHHHHCHHHHHHHH	40.26	22790023
250	Phosphorylation	GGQGAKKSAIGQRIV CCCCCCHHHHCCHHH	25.14	-
264	Ubiquitination	VATLPYIKQEVPIII HHCHHHHCCCCCEEE	34.26	-
340	Ubiquitination	EKRIKYAKEVLQKEM HHHHHHHHHHHHHHC	45.31	22790023
457	Ubiquitination	TGNWGDQKKAHQARA CCCCCCHHHHHHHHH	57.58	22790023
487	Phosphorylation	SHLRRLNSPIGRDGK HHHHHHCCCCCCCCC	23.61	29472430
644	Acetylation	KRHIDQLKEREYNNY HHHHHHHHHHHCCCC	49.44	23806337
644	Succinylation	KRHIDQLKEREYNNY HHHHHHHHHHHCCCC	49.44	23806337
730	Ubiquitination	TYQSAMGKQAMGVYI HHHHHHHHHHCEEEE	23.07	22790023
756	Ubiquitination	HVLYYPQKPLVTTRS HHHHCCCCCCEECCC	35.50	22790023
763	Phosphorylation	KPLVTTRSMEYLRFR CCCEECCCHHHHHHC	17.55	22006019
831	Ubiquitination	DQEEVFEKPTRETCQ CHHHHHCCCCHHHHH	39.98	22790023
845	Phosphorylation	QGMRHAIYEKLDDDG HHHHHHHHHHCCCCC	14.06	25367039
847	Ubiquitination	MRHAIYEKLDDDGLI HHHHHHHHCCCCCCC	40.00	22790023
869	Ubiquitination	GDDVIIGKTVTLPEN CCCEEEECEEECCCC	29.43	22790023
870	Phosphorylation	DDVIIGKTVTLPENE CCEEEECEEECCCCH	17.32	25338131
934	Ubiquitination	RIPQIGDKFASRHGQ ECCCCCHHHHHHHCC	37.30	22790023
937	Phosphorylation	QIGDKFASRHGQKGT CCCHHHHHHHCCCCC	28.13	-
993	Ubiquitination	QGKVSANKGEIGDAT HCCCCCCCCCCCCCC	58.60	22790023
1010	Ubiquitination	NDAVNVQKISNLLSD CCCCCHHHHHHHHHH	43.76	22790023
1036	Ubiquitination	YNGFTGRKITSQIFI ECCCCCCEECEEEEE	52.24	22790023
1047	Phosphorylation	QIFIGPTYYQRLKHM EEEECCHHHHHHHHH	10.75	28576409
1052	Methylation	PTYYQRLKHMVDDKI CHHHHHHHHHHCHHH	31.66	-
1144	Phosphorylation	CRGCRNKTQISLVRM CCCCCCCCCEEEEEH	34.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPB2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RPB2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.