VP13C_MOUSE - dbPTM
VP13C_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VP13C_MOUSE
UniProt AC Q8BX70
Protein Name Vacuolar protein sorting-associated protein 13C
Gene Name Vps13c {ECO:0000312|MGI:MGI:2444207}
Organism Mus musculus (Mouse).
Sequence Length 3748
Subcellular Localization Mitochondrion outer membrane .
Protein Description Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization..
Protein Sequence MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAEKEEKSLQDIKQKELCRIEEALQKAAEKGAHSGEFMYGLENLLYKDVKPGRKRKKHKKHFKKRFKGLDRSKDKPKEAKKDTFLEKLATQVIKNVQVKITDIHIKYEDDITDPERPLSFGVTLREFSLLTTNEHWTPCILNEAEKIIYKLVKLDSLSAYWNVGCCMSYRGSREHILEQLKREILTSTNIPPDHQYIFQPISASAKLYMNPGAESELKTPKLDGNVEVQNIAIELTKPQYLSMIDFLESLDYMVRNAPYRKYKPCLPLHTNCRQWWKYAIDSVLEVHIRRYTQPWSWSNIKNHRQLLKSYKMAYKTKLTQAKVSEEIQKQIQDLEKSLDVFNIILVRQQAQVEVIHSGQKLRKKSAEAGEKRGWFSGFWGKKESKKRDEESSVPETIDDLMTPEEKDKLFTAIGYSENAYNLALPKQYVAHILTLKLVSTSIIIRENRNVPEILRVQIIGLGTQVSQRPGAQALKIEAKLEHWYVTGLRQQDIVPSLVASIGDTTSSLLKIEFETNPENSPADQTLIVQSQPVEVIYDAKTINAVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLIIPQTGFHHEKSNLLILDFGTFQLNSKDQGAQKTANASLEEIIDKAYDKFDVEIRSVQLLFAKAEENWKKCRFQHPSTMHILQPMDIHVELAKAMVEKDVRMAKFKVSGGLPLMHVRISDQKIKDALCLINSIPLPQKSSTPSPERQVASIPVLSGGTKALLGTSLLLDGVESESDEEFFDAEDGDSQAARTVKASELKKAAEVPNEELVSLLLKFEIKEVVLELTKQQKEEETILVFNVTQLGTEATMRTFDLTAVSYLRKISLDYHDIKGSRKKPIHLISSSDRPGLDLLKVEYIKVDRNGPSFQTTFEKTEQTVKVAFSSLNLLLQTQALLSSLNYLTTVIPSDSQNTGVAKEVQAMPEKQKNSPLQKVMVPSRDSDVIGFRLFAKLNAFCVTVCDEKSNIAEIKIQGLDSSLSLQSKKQSLFARLENIIVTDVDPKTIHKKAVSIVGNEVFRFNLDLYPDATEGDSYTDMSTVDGVVALHVGCIQIVYLHKFLMSLLSFLNNFQVAKEALSAATAQAAEKAATSVKDLAQRSFRVSVDIDLKAPVIVIPQSSLSTNAVVVDLGLIRVHNRFSLVSGEDTANPPVIDKMEVQLTKLKLSRTAIQPGTSHPDIQLLHPINLEFFVSRNLAANWYHKVPVVEIKGRLDSMNVSLNQEDLNLLFRILAENLGEATEDLDKGKPRIQERGETKACREVSTPQDVHTTQGVPAARVEETRPVDIINVLLNFEIKEVVVTLMKKAERKGSPFHELKILHLGMEAKVKAHDMTAAAYLRNISMRCFHFPDSKGEPLRIVNTSDVSDGILLKLLFIKADSDGPDFKTIHDNTKQKLKVSFSSLDLVLHLEALLSLMDFLSSAIPSSDSSSSEKEPELKPLVGESRSLAIRAVPSSYEGDAFDLKITAELNAFNIFICDQKSNIAEIKIHGMDASISVKPKQTDVFARLKNIIVMNVDSLSIHKKAVSILGDEVFRFQMSLYPDATEGENYGDMSKVDGRLSLKVGCIQIVYVHKFFMSLLSFLNNFQAAKEALSTATVQAAERAASSVKDLAQKSFRLLMDIDLKAPVITIPQSSVSPNVVIADLGLIRVENKFSLVSVEQLALPPVADEMSIQLTQLKLARTVLQADSPQHDVEILKPVNMLLCIQRNLSAAWYTQIPGMEIKGELKPMQVALSQDDLTVLMKILLENLGEASSQPSPTQYAQEAARVKRDTRSGPDYLKEQELADPKPPGDQTVTLQFDFHFDSLSIILYNSDSSQEPRLSFHNDSFRLGELTLHLMASAGKMFKDGSMNVSLKLKTCTLDDLREGIERATSRMIDKKNDQDNNSSMIDISYSQDKNGSQVDAVLDKLYVCASVEFLMTVADFFIKAMPQSPENIAKEIQIPSRQTAAGRVKMEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACPFLRERRGKSITTVLQPCSLFMEKCTWASGKQNINIVVKEFVIKISPIILNTVMTIMAAMSPKTKEDEWKDTPKETDNLWAVKSITDYNSWFLGVDMATEVTENFRDSEHPSIEENCVVAVESVQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAAADMTLEVHYYNETHAVWEPLIERVEGNKPWSLKLNVKKNPIQDKSLMPGDDFIPEPQTAVHISSGATMNITISKSCLNVFSNLAKGFSEGAASTFDYSLKDRAPFTVKNALGVPMKVQPNRNLKVMGSPEKSDIYDVGAGQHLELDYASLEPSRQGKLSILSRQESSLFTLTFVPYGYTEVASVPVARPGRRLYNVRNPSASHSDSVLVQIDATEGNKVVTLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLYVQPAGGLEQQYTHSSTYISWKEELHRSREVRCMLQCPAVEVSFLPLIVNTVALPDELSYIGAHGEDWDPAYVIHLYPPLTLRNLLPYSLRYLLEGTAETHELAEGSSADVLHSRISGEIIELVLVKYLGKNWNGHFRICDTLPEFFLVCFSSDTAEVMTVDLSVHVRRIGCRMELSVFSPYWLINKTSRVLQYRSEEIHVKHPADFRDIILFSFKKKNIFSKNKVQLKISTSAWSNGFSLDTVGSYGCVKCPATNMEYLVGVSIKMSSFNLSRVVTLTPFCTVANKSSLDLEVGEIASDGSIPTNKWHYVASSECIPFWPENLSGKLCVRVVGYEGSSKPFFYNRQDNGTLLSLEDLNGGILVDINTAEHSTVITFSDYHEGSAPALIMNHTQWDVLTYKQSGSQEELVLLPGETRLFAWADPTGIRKLTWNYAANFGEHDLLKDECGQFPYDANIQIHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQADHEVALSLHSLGLSLVNNENKQEVSYVGITSSGVVWEMKPKQKWKPFSQKQIMSLEQAYSKRLASQDRGWVKLDSNFEVNFDKVPMEMRLPIRCPIKRDFLSGIQVEFKQSPHQRSLRARLYWLQVDNQLPGTMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQFKYFMVLIQEMALKVDQGFLGAVISLFTPTTDPEAERKRTKLIQQDIDALNTELMESSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMIAIHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLMWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLVGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREEMGRQPKDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIIDMASSTFQGIQRVAESTEEVSSLRPPRLIHEDGIIRPYDRQESEGSDLLENHIKKLEGEAYQFHCAVPGNKRAVLMITNRRALFIKEVEILGHMSVDWQCLFEDFVCPPEVSENLLKISVKEQGLFHKKDSANIGHLRKIYLKDPITAKRAFDAIESAQSARQQQKLMRQSSVKLLRPQGPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
132PhosphorylationAAEKGAHSGEFMYGL
HHHCCCCCHHHHHHH		39.2119060867
188PhosphorylationTFLEKLATQVIKNVQ
CHHHHHHHHHHHHCE		33.53-
254PhosphorylationYKLVKLDSLSAYWNV
HHHHCHHCCHHHCCC		34.36-
306PhosphorylationISASAKLYMNPGAES
CCCCCEEECCCCCCC		8.3025777480
313PhosphorylationYMNPGAESELKTPKL
ECCCCCCCCCCCCCC		47.9325777480
389PhosphorylationLEVHIRRYTQPWSWS
HHHHHHHHCCCCCHH		10.4025521595
394PhosphorylationRRYTQPWSWSNIKNH
HHHCCCCCHHHHHHH		27.5825521595
396PhosphorylationYTQPWSWSNIKNHRQ
HCCCCCHHHHHHHHH		24.1425521595
469AcetylationKSAEAGEKRGWFSGF
HHHHHHHHCCCCCCC		56.127718615
500PhosphorylationETIDDLMTPEEKDKL
CHHHHHCCHHHHHHH		34.5429899451
577UbiquitinationQALKIEAKLEHWYVT
CCEEEEEEHHHEEEC		41.43-
613PhosphorylationLLKIEFETNPENSPA
CEEEEEECCCCCCCC		62.49-
618PhosphorylationFETNPENSPADQTLI
EECCCCCCCCCCEEE		21.58-
623PhosphorylationENSPADQTLIVQSQP
CCCCCCCEEEEECCC		20.99-
732PhosphorylationKDQGAQKTANASLEE
CCHHHHHHHCCCHHH		17.0526745281
736PhosphorylationAQKTANASLEEIIDK
HHHHHCCCHHHHHHH		35.8025521595
837PhosphorylationSIPLPQKSSTPSPER
CCCCCCCCCCCCHHH		33.9122324799
838PhosphorylationIPLPQKSSTPSPERQ
CCCCCCCCCCCHHHE		51.9122324799
839PhosphorylationPLPQKSSTPSPERQV
CCCCCCCCCCHHHEE		34.5722324799
841PhosphorylationPQKSSTPSPERQVAS
CCCCCCCCHHHEECC		39.2122324799
848PhosphorylationSPERQVASIPVLSGG
CHHHEECCCEEECCH		28.6826745281
862PhosphorylationGTKALLGTSLLLDGV
HHHHHHCEEHHHCCC		19.0326643407
863PhosphorylationTKALLGTSLLLDGVE
HHHHHCEEHHHCCCC		18.4126643407
871PhosphorylationLLLDGVESESDEEFF
HHHCCCCCCCCHHCC		39.7421082442
873PhosphorylationLDGVESESDEEFFDA
HCCCCCCCCHHCCCC		60.6521082442
885PhosphorylationFDAEDGDSQAARTVK
CCCCCCCCHHHHHCC		27.5225293948
909PhosphorylationVPNEELVSLLLKFEI
CCCHHHHHHHHHHHH		26.3928059163
962PhosphorylationVSYLRKISLDYHDIK
HHHHHHHCCCHHCCC		20.4425338131
1065PhosphorylationMPEKQKNSPLQKVMV
CCHHHCCCCCCEEEC		33.7429899451
1295PhosphorylationDKMEVQLTKLKLSRT
CHHHHEEEEEEEECC		19.7620047950
1396PhosphorylationTKACREVSTPQDVHT
CCCCCCCCCCCCCCC		29.6223684622
1397PhosphorylationKACREVSTPQDVHTT
CCCCCCCCCCCCCCC		30.0926824392
1403PhosphorylationSTPQDVHTTQGVPAA
CCCCCCCCCCCCCCC		22.2120415495
1435PhosphorylationEIKEVVVTLMKKAER
CHHHHHHHHHHHHHH		14.9919144319
1660PhosphorylationSIHKKAVSILGDEVF
CCHHHHHHHHCCHHE		19.5620139300
1672PhosphorylationEVFRFQMSLYPDATE
HHEEEEEECCCCCCC		17.61-
1674PhosphorylationFRFQMSLYPDATEGE
EEEEEECCCCCCCCC		7.55-
1678PhosphorylationMSLYPDATEGENYGD
EECCCCCCCCCCCCC		52.48-
1683PhosphorylationDATEGENYGDMSKVD
CCCCCCCCCCHHHCC		15.36-
1887PhosphorylationLENLGEASSQPSPTQ
HHHCCCCCCCCCHHH		25.7924925903
1888PhosphorylationENLGEASSQPSPTQY
HHCCCCCCCCCHHHH		53.8324925903
1891PhosphorylationGEASSQPSPTQYAQE
CCCCCCCCHHHHHHH		32.7025521595
1893PhosphorylationASSQPSPTQYAQEAA
CCCCCCHHHHHHHHH		38.2525521595
1895PhosphorylationSQPSPTQYAQEAARV
CCCCHHHHHHHHHHH		16.8425521595
1908PhosphorylationRVKRDTRSGPDYLKE
HHHCCCCCCCCHHCH		57.6929899451
1956PhosphorylationSSQEPRLSFHNDSFR
CCCCCCEECCCCCEE		26.2425159016
1961PhosphorylationRLSFHNDSFRLGELT
CEECCCCCEEHHHHH		19.9925159016
1968PhosphorylationSFRLGELTLHLMASA
CEEHHHHHHHHHHHC		14.0819131326
1974PhosphorylationLTLHLMASAGKMFKD
HHHHHHHHCCCCCCC		24.4819131326
1983PhosphorylationGKMFKDGSMNVSLKL
CCCCCCCCCEEEEEE		19.8128059163
2072UbiquitinationQSPENIAKEIQIPSR
CCHHHHHHHCCCCCC		52.10-
2093PhosphorylationVKMEKDDSVRPNMTL
CCCCCCCCCCCCCEE		30.1129899451
2132PhosphorylationASFQCNLSLSTSKLE
HEEEECEECCHHHHH		13.2928066266
2134PhosphorylationFQCNLSLSTSKLEQM
EEECEECCHHHHHHH		27.5328833060
2135PhosphorylationQCNLSLSTSKLEQMM
EECEECCHHHHHHHH		34.8628066266
2150UbiquitinationEASVRDLKVLACPFL
HHHHHHHHHHHCHHH		39.22-
2185AcetylationKCTWASGKQNINIVV
HCCCCCCCCCEEEEE		37.3619855083
2215PhosphorylationMTIMAAMSPKTKEDE
HHHHHHCCCCCCCCC		20.6528059163
2218PhosphorylationMAAMSPKTKEDEWKD
HHHCCCCCCCCCCCC		42.9528059163
2407PhosphorylationGFSEGAASTFDYSLK
CCCCCCHHHCCCCCC		29.1322807455
2422UbiquitinationDRAPFTVKNALGVPM
CCCCCEEECCCCCCE		33.18-
2442PhosphorylationRNLKVMGSPEKSDIY
CCEEECCCCCCCCCE		16.2819060867
2446PhosphorylationVMGSPEKSDIYDVGA
ECCCCCCCCCEECCC		27.8119060867
2449PhosphorylationSPEKSDIYDVGAGQH
CCCCCCCEECCCCCE		15.0125293948
2461PhosphorylationGQHLELDYASLEPSR
CCEEEEEECCCCHHH		15.6625293948
2480PhosphorylationSILSRQESSLFTLTF
EEEECCCCCCEEEEE		24.8123608596
2781PhosphorylationSRVLQYRSEEIHVKH
CHHHCCCCEECCCCC		34.3522817900
2799PhosphorylationFRDIILFSFKKKNIF
HHHEEEEEECCCCCC		32.4830387612
3379PhosphorylationDLIFKLAYYEIRYQF
HHHHHHHHHHHHHHH		16.4429514104
3380PhosphorylationLIFKLAYYEIRYQFY
HHHHHHHHHHHHHHH		10.1629514104
3477PhosphorylationAGVVSRITGSVGKGL
HHHHHHHHCCCCCCE		23.4628059163
3479PhosphorylationVVSRITGSVGKGLAA
HHHHHHCCCCCCEEH		21.0324719451
3488PhosphorylationGKGLAAITMDKEYQQ
CCCEEHHHCCHHHHH		18.0028059163
3493PhosphorylationAITMDKEYQQKRREE
HHHCCHHHHHHHHHH		23.2225159016
3511PhosphorylationQPKDFGDSLARGGKG
CCCCHHHHHHHCCCC		25.0629176673
3514MethylationDFGDSLARGGKGFLR
CHHHHHHHCCCCCHH		60.7424129315
3521MethylationRGGKGFLRGVVGGVT
HCCCCCHHHHHCCEE		33.33-
3533AcetylationGVTGIITKPVEGAKK
CEEEEEECCCCCCCC		36.34-
3552MalonylationGFFKGIGKGLVGAVA
HHCCCCCCHHHHCCC		47.3426320211
3604 (in isoform 2)Phosphorylation-17.5729899451
3609PhosphorylationRPYDRQESEGSDLLE
CCCCCCCCCCCHHHH		38.6325338131
3609 (in isoform 2)Phosphorylation-38.6329899451
3612PhosphorylationDRQESEGSDLLENHI
CCCCCCCCHHHHHHH		22.4930635358
3612 (in isoform 2)Phosphorylation-22.4929899451
3621 (in isoform 2)Phosphorylation-51.6829899451
3697PhosphorylationGLFHKKDSANIGHLR
CCCCCCCCCCCCCCE		31.9025338131
3737PhosphorylationQQKLMRQSSVKLLRP
HHHHHHHHHHHHHCC		27.0819060867
3738PhosphorylationQKLMRQSSVKLLRPQ
HHHHHHHHHHHHCCC		18.2219060867
3748PhosphorylationLLRPQGPS-------
HHCCCCCC-------		60.7322942356
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VP13C_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VP13C_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VP13C_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VP13C_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VP13C_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1968 AND SER-1974, ANDMASS SPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1435, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory