dbPTM

DAB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DAB1_MOUSE
UniProt AC	P97318
Protein Name	Disabled homolog 1
Gene Name	Dab1
Organism	Mus musculus (Mouse).
Sequence Length	588
Subcellular Localization
Protein Description	Adapter molecule functioning in neural development. May regulate SIAH1 activity..
Protein Sequence	MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPNSQPLEDFESRFAAATPNRNLSMDFDELLEATKVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPSSSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIPGAQPIAWGQPGLFPATQQAWPTVAGQFPPAAFMPTQTVMPLAAAMFQGPLTPLATVPGTNDSARSSPQSDKPRQKMGKESFKDFQMVQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDIFEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTETELQV ------CCCHHHHHH	34.64	29895711
3	Phosphorylation	-----MSTETELQVA -----CCCHHHHHHH	45.70	28576409
5	Phosphorylation	---MSTETELQVAVK ---CCCHHHHHHHHH	41.92	29895711
13	Phosphorylation	ELQVAVKTSAKKDSR HHHHHHHHCCCCCHH	27.58	29895711
143	Phosphorylation	HRFVAIKTAQAAEPV EEEEEEEECHHCCCE	20.21	25777480
162	Phosphorylation	RDLFQLIYELKQREE HHHHHHHHHHHHHHH	24.65	25777480
185	Phosphorylation	KQCEQAVYQTILEED HHHHHHHHHHHHHHH	11.71	19796633
198	Phosphorylation	EDVEDPVYQYIVFEA HHCCCCCCEEEEEEC	10.86	19796633
200	Phosphorylation	VEDPVYQYIVFEAGH CCCCCCEEEEEECCC	4.95	22586277
220	Phosphorylation	PETEENIYQVPTSQK CCCCCCEEECCCCCC	18.29	19796633
232	Phosphorylation	SQKKEGVYDVPKSQP CCCCCCCCCCCCCCC	23.29	19796633
246 (in isoform 3)	Phosphorylation	-	61.36	-
261	Phosphorylation	ATPNRNLSMDFDELL CCCCCCCCCCHHHHH	21.61	29472430
265 (in isoform 3)	Phosphorylation	-	41.17	30635358
418	Phosphorylation	AMFQGPLTPLATVPG HHHCCCCCCCEECCC	21.27	-
432	Phosphorylation	GTNDSARSSPQSDKP CCCCCCCCCCCCCCH	46.19	29899451
433	Phosphorylation	TNDSARSSPQSDKPR CCCCCCCCCCCCCHH	22.77	23384938
503	Phosphorylation	DISQLNLTPVTSTTP CHHHCCCEECCCCCC	18.03	-
509	Phosphorylation	LTPVTSTTPSTNSPP CEECCCCCCCCCCCC	18.27	-
514	Phosphorylation	STTPSTNSPPTPAPR CCCCCCCCCCCCCCC	32.14	-
517	Phosphorylation	PSTNSPPTPAPRQSS CCCCCCCCCCCCCCC	35.15	-
524	Phosphorylation	TPAPRQSSPSKSSAS CCCCCCCCCCCCCCC	25.50	16141072
548	Phosphorylation	IFEEGFESPSKSEEQ HHHHCCCCCCCCCCC	32.01	-
552	Phosphorylation	GFESPSKSEEQEAPD CCCCCCCCCCCCCCC	51.18	-
583	Phosphorylation	EPSGDNISPQDGS-- CCCCCCCCCCCCC--	23.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
198	Y	Phosphorylation	Kinase	SRC	P12931	PSP
198	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
220	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
220	Y	Phosphorylation	Kinase	SRC	P12931	PSP
220	Y	Phosphorylation	Kinase	SRC	P05480	PSP
220	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
232	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
232	Y	Phosphorylation	Kinase	SRC	P12931	PSP
232	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
246	S	Phosphorylation	Kinase	CDK5	P49615	PSP
524	S	Phosphorylation	Kinase	CDK5	P49615	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
524	S	Phosphorylation		12077184
Also phosphorylated on Ser-524 independently of reelin signaling.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DAB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WASP_MOUSE	Was	physical	15361067
CUL5_MOUSE	Cul5	physical	17974915
PLCG1_MOUSE	Plcg1	physical	15062102
SRC_MOUSE	Src	physical	15062102
YES_MOUSE	Yes1	physical	15062102
CRKL_MOUSE	Crkl	physical	15062102
DAB2P_MOUSE	Dab2ip	physical	12877983
PTN11_MOUSE	Ptpn11	physical	15062102
CRK_MOUSE	Crk	physical	15062102

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DAB1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Cyclin-dependent kinase 5 phosphorylates disabled 1 independently ofreelin signaling."; Keshvara L., Magdaleno S., Benhayon D., Curran T.; J. Neurosci. 22:4869-4877(2002). Cited for: PHOSPHORYLATION AT SER-524.	12077184 [Abstract]
"Identification of reelin-induced sites of tyrosyl phosphorylation ondisabled 1."; Keshvara L., Benhayon D., Magdaleno S., Curran T.; J. Biol. Chem. 276:16008-16014(2001). Cited for: PHOSPHORYLATION AT TYR-198 AND TYR-220.	11279201 [Abstract]

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