DESP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DESP_MOUSE
• UniProt AC: E9Q557
• Protein Name: Desmoplakin
• Gene Name: Dsp
• Organism: Mus musculus (Mouse).
• Sequence Length: 2883
• Subcellular Localization: Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (By similarity). Localizes at
• Protein Description: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes..
• Protein Sequence: MSCNGGSHPRINTLGRMTRAESGPDLRYEMTYSGGGGGGGGGGGGGTSRTFYSHSRRCTVNDQNSDGYCQTGTMSRHQNQNTIQEMLQNCSDCLMRAELIAQPELKFGEGMQLAWNRELDEYFTQANDQMEIIDGLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGAGGYTCQSGSGWDEFTKRLTGECLGWMRQQREEMDLMAWGVDAGSVEQHINSHRSIHNTIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKIIEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIEDLELHYQDFIKNSQGSEMFGDDDKRRMQSQFTDAQKHYQTLVIQLPGHPQHQTVTKTEITHLGTCQDVNHNKVIETNRENDKQETWLLMELQKIRRQMEHCEARMTLKNLLLAEQGSTHHITVKINELKSVQNDSQALAEVLNQLKDMLANFRGSEKYCYLQNEIFGLFQKLENINGVSDGYLNSLCSVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQSSQQYPLYDLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVHKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMVQSPSGVILQEAADIHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLVSLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQQKNDYDQLQKARQCEKENLSWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQMDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSETMQKKQRLEIELKQVIQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEYQEEAKRRWEYENELSKVRNSYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLCEEVKRLKNTLAQTTENLRRVEENAQQQKATGSEMSQRKQQLEIELRQVTQMRTEESMRYKQSLDDAAKTIQDKNKEIERLKQLVDKETNERKCLEDENSKLQRVQYDLQKANNSATEAMSKLKVQEQELTRLRIDYERVSQERTVKDQDITRIQSSLKDLQLQKQKAEEELSRLKRTASDESSKRKMLEEELEAMRRSLKEQAVKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHVREKQRTQEELRRLSLDVEALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNSTISELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKATLEAESRVKQRLECEKQQIQNDLNQWKTQYSRKEETIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSSRETQSQLESERCRLQKEIEKLRQRPYGSHRETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKLTVDNAVARDLIDFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQLASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPITKKKVSYMQLRERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDMAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYDTFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGNSSGLGGSVNDDVFSSSRHDSVSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTENLEKISIAEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVNQGLIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQFLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDISSYAKILTCPKTKLKISYKDAMNRSMVEDITGLRLLEAASVSSKGLPSPYNMSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCNGGSHP ------CCCCCCCCC	27.82	26239621
3	S-palmitoylation	-----MSCNGGSHPR -----CCCCCCCCCC	9.26	26165157
7	Phosphorylation	-MSCNGGSHPRINTL -CCCCCCCCCCCCCC	31.55	23737553
13	Phosphorylation	GSHPRINTLGRMTRA CCCCCCCCCCCCCCC	28.37	21183079
18	Phosphorylation	INTLGRMTRAESGPD CCCCCCCCCCCCCCC	25.93	23737553
22	Phosphorylation	GRMTRAESGPDLRYE CCCCCCCCCCCCEEE	55.42	27087446
28	Phosphorylation	ESGPDLRYEMTYSGG CCCCCCEEEEEECCC	19.83	26239621
31	Phosphorylation	PDLRYEMTYSGGGGG CCCEEEEEECCCCCC	11.55	23984901
32	Phosphorylation	DLRYEMTYSGGGGGG CCEEEEEECCCCCCC	12.19	26239621
33	Phosphorylation	LRYEMTYSGGGGGGG CEEEEEECCCCCCCC	23.07	26239621
47	Phosphorylation	GGGGGGGTSRTFYSH CCCCCCCCCCCEECC	20.50	23140645
48	Phosphorylation	GGGGGGTSRTFYSHS CCCCCCCCCCEECCC	32.38	25521595
50	Phosphorylation	GGGGTSRTFYSHSRR CCCCCCCCEECCCCC	27.05	29472430
52	Phosphorylation	GGTSRTFYSHSRRCT CCCCCCEECCCCCEE	12.59	23140645
53	Phosphorylation	GTSRTFYSHSRRCTV CCCCCEECCCCCEEC	15.70	23737553
55	Phosphorylation	SRTFYSHSRRCTVND CCCEECCCCCEECCC	18.58	23737553
59	Phosphorylation	YSHSRRCTVNDQNSD ECCCCCEECCCCCCC	22.11	25521595
65	Phosphorylation	CTVNDQNSDGYCQTG EECCCCCCCCCCCCC	27.12	25521595
68	Phosphorylation	NDQNSDGYCQTGTMS CCCCCCCCCCCCCCC	6.08	19060867
71	Phosphorylation	NSDGYCQTGTMSRHQ CCCCCCCCCCCCCCC	30.93	23140645
73	Phosphorylation	DGYCQTGTMSRHQNQ CCCCCCCCCCCCCCH	18.50	19060867
75	Phosphorylation	YCQTGTMSRHQNQNT CCCCCCCCCCCCHHH	26.84	20469934
152	Ubiquitination	QPCDAYQKRLLQLQE CCCHHHHHHHHHHHH	32.13	22790023
166	Ubiquitination	EQMRALYKAISVPRV HHHHHHHHHCCCCCC	39.84	22790023
169	Phosphorylation	RALYKAISVPRVRRA HHHHHHCCCCCCCCC	30.81	23375375
177	Phosphorylation	VPRVRRASSKGAGGY CCCCCCCCCCCCCCC	30.67	27742792
178	Phosphorylation	PRVRRASSKGAGGYT CCCCCCCCCCCCCCC	33.84	27087446
184	Phosphorylation	SSKGAGGYTCQSGSG CCCCCCCCCCCCCCC	11.92	26239621
185	Phosphorylation	SKGAGGYTCQSGSGW CCCCCCCCCCCCCCH	13.82	26239621
188	Phosphorylation	AGGYTCQSGSGWDEF CCCCCCCCCCCHHHH	36.75	25521595
190	Phosphorylation	GYTCQSGSGWDEFTK CCCCCCCCCHHHHHH	41.79	26239621
196	Phosphorylation	GSGWDEFTKRLTGEC CCCHHHHHHHHHHHH	17.13	27742792
197	Ubiquitination	SGWDEFTKRLTGECL CCHHHHHHHHHHHHH	51.21	22790023
249	Ubiquitination	DYRWQLDKIKADLRE HHHHHHHHHCHHHHH	55.49	-
258	Phosphorylation	KADLREKSAIYQLEE CHHHHHHHHHHHHHH	18.36	17242355
443	Phosphorylation	EREKIIEYKRQVQNL HHHHHHHHHHHHHHH	10.89	20469934
453	Ubiquitination	QVQNLVNKSKKIVQL HHHHHHHHCCCHHCC	57.06	22790023
463	Methylation	KIVQLKPRNPDYRSN CHHCCCCCCCCCCCC	66.77	-
467	Phosphorylation	LKPRNPDYRSNKPII CCCCCCCCCCCCCHH	19.73	-
469	Phosphorylation	PRNPDYRSNKPIILR CCCCCCCCCCCHHHH	42.87	-
479	S-palmitoylation	PIILRALCDYKQDQK CHHHHHHCCCCCCCC	5.40	26165157
482	Ubiquitination	LRALCDYKQDQKIVH HHHHCCCCCCCCCEE	33.86	22790023
519	Phosphorylation	GVDMLVPSVGLIIPP CCCEEECCCEEEECC	22.72	-
576	Phosphorylation	IEKIRAMTIAKLKTM HHHHHHHHHHHHHHC	19.46	23375375
606	Phosphorylation	YQDFIKNSQGSEMFG HHHHHHCCCCCCCCC	30.80	23375375
609	Phosphorylation	FIKNSQGSEMFGDDD HHHCCCCCCCCCCHH	20.46	23375375
778	Phosphorylation	VSDGYLNSLCSVRAL CCHHHHHHHHHHHHH	28.32	22324799
781	Phosphorylation	GYLNSLCSVRALLQA HHHHHHHHHHHHHHH	21.67	22324799
792	Phosphorylation	LLQAILQTEDMLKVY HHHHHHCCHHHHHHH	30.43	29899451
841	Ubiquitination	KSLLATMKTELQKAQ HHHHHHHHHHHHHHH	34.20	22790023
923	Phosphorylation	DAKRRQDSLESMKFG HHHHHHHHHHHCCCC	26.21	27742792
926	Phosphorylation	RRQDSLESMKFGDSN HHHHHHHHCCCCCHH	32.34	27742792
1035	Phosphorylation	FLSEMLKSLEDLKLK HHHHHHHCHHHHCCC	32.79	22324799
1045	Ubiquitination	DLKLKNTKIEVLEEE HHCCCCCCHHHHHHH	46.38	22790023
1082	Phosphorylation	QKYQAECSQFKAKLV HHHHHHHHHHHHHHC	30.11	-
1085	Ubiquitination	QAECSQFKAKLVSLE HHHHHHHHHHHCCHH	36.65	22790023
1090	Phosphorylation	QFKAKLVSLEELKRQ HHHHHHCCHHHHHHH	40.26	23737553
1151	Phosphorylation	FDQQKNDYDQLQKAR HHHHHCCHHHHHHHH	18.25	-
1156	Ubiquitination	NDYDQLQKARQCEKE CCHHHHHHHHHHHHH	54.88	22790023
1172	Phosphorylation	LSWQKLESEKAIKEK CCHHHHHHHHHHHHH	55.63	-
1222	Phosphorylation	MSNLRNKYETEINIT HHHHHHHHHHHEEEC	31.47	21183079
1224	Phosphorylation	NLRNKYETEINITKT HHHHHHHHHEEECHH	38.79	21183079
1229	Phosphorylation	YETEINITKTTIKEI HHHHEEECHHHHHHH	20.18	21183079
1294	Phosphorylation	LQQKACGSETMQKKQ HHHHHHCCHHHHHHH	29.76	20531401
1296	Phosphorylation	QKACGSETMQKKQRL HHHHCCHHHHHHHHH	26.97	20531401
1315	Phosphorylation	KQVIQQRSEDNARHK HHHHHHHCHHCHHHH	44.99	-
1324	Phosphorylation	DNARHKQSLEEAAKT HCHHHHHHHHHHHHH	42.42	-
1331	Phosphorylation	SLEEAAKTIQDKNKE HHHHHHHHHHHHHHH	21.10	26239621
1373	Phosphorylation	SYDEEIISLKNQFET CCCHHHHHHCHHHHE	38.66	27742792
1422	Acetylation	RSLCEEVKRLKNTLA HHHHHHHHHHHHHHH	56.12	7923761
1422	Malonylation	RSLCEEVKRLKNTLA HHHHHHHHHHHHHHH	56.12	26320211
1524	Phosphorylation	SKLQRVQYDLQKANN HHHHHHHHHHHHHCH	18.76	-
1528	Ubiquitination	RVQYDLQKANNSATE HHHHHHHHHCHHHHH	61.45	22790023
1554	Phosphorylation	LTRLRIDYERVSQER HHHHHCCHHHHHCCC	11.85	-
1641	Phosphorylation	ASIVKKRSEDDLRQQ HHHHHCCCHHHHHHH	55.01	-
1670	Phosphorylation	QEELRRLSLDVEALR HHHHHHHHCCHHHHH	22.25	26239621
1720	Phosphorylation	IEIERLQSLTENLTK HHHHHHHHHHHHCCH	41.68	23737553
1722	Phosphorylation	IERLQSLTENLTKEH HHHHHHHHHHCCHHH	28.24	27742792
1759	Phosphorylation	EADSDKNSTISELRS CCCCCCCCHHHHHHH	32.62	27742792
1760	Phosphorylation	ADSDKNSTISELRSQ CCCCCCCHHHHHHHH	37.61	27742792
1762	Phosphorylation	SDKNSTISELRSQLQ CCCCCHHHHHHHHHH	30.57	27742792
1919	Malonylation	ERLQAEIKRIEERCR HHHHHHHHHHHHHHH	38.54	26320211
1949	Malonylation	SERCRLQKEIEKLRQ HHHHHHHHHHHHHHC	66.31	26320211
1969	Phosphorylation	HRETQTEYEWTVDSS CCCCCCEEEEEECCC	21.83	-
2012	Phosphorylation	KLLKGKKSVEEVASE HHHCCCCCHHHHHHH	37.94	28507225
2018	Phosphorylation	KSVEEVASEIQPFLR CCHHHHHHHHHHHHC	40.17	-
2036	Phosphorylation	AIAGASASPKEKYSL HHCCCCCCHHHHCCH	33.73	28973931
2099	Phosphorylation	FDDRQQIYTAEKAIT CCCHHHHHHHHHHHC	8.78	-
2132	Phosphorylation	KNLIDRETGMRLLEA HCCCCHHHHHHHHHH	36.85	25195567
2219	Phosphorylation	LLSVQKRSMSFQGIR EEEEECCCCCCCCCC	26.30	26239621
2221	Phosphorylation	SVQKRSMSFQGIRQP EEECCCCCCCCCCCC	18.70	27742792
2230	Phosphorylation	QGIRQPVTVTELVDS CCCCCCEEEEHHHHC	28.52	26239621
2232	Phosphorylation	IRQPVTVTELVDSGI CCCCEEEEHHHHCCC	17.78	26239621
2237	Phosphorylation	TVTELVDSGILRPST EEEHHHHCCCCCCCC	21.91	26239621
2243	Phosphorylation	DSGILRPSTVNELES HCCCCCCCCCCCHHC	38.26	26239621
2244	Phosphorylation	SGILRPSTVNELESG CCCCCCCCCCCHHCC	29.99	26239621
2250	Phosphorylation	STVNELESGQISYDE CCCCCHHCCCCCHHH	48.93	26239621
2329	Acetylation	LPVEEAYKRGLVGIE CCHHHHHHCCCCCHH	47.22	1533341
2343	Phosphorylation	EFKEKLLSAERAVTG HHHHHHHCCHHHHCC	38.22	27149854
2418	Phosphorylation	EELSEILSDPSDDTK HHHHHHHCCCCCCCC	53.81	20531401
2492	Hydroxyceramide ester	TNKEMSVQEAYKKGL CCCCCCHHHHHHCCC	23.46	-
2536	Phosphorylation	VVLVDRKTGSQYDIQ EEEEECCCCCCCCHH	42.85	23737553
2538	Phosphorylation	LVDRKTGSQYDIQDA EEECCCCCCCCHHHH	30.69	27742792
2540	Phosphorylation	DRKTGSQYDIQDAID ECCCCCCCCHHHHHH	19.40	27742792
2561	Phosphorylation	KFFDQYRSGSLSLTQ HHHHHHHCCCCCHHH	28.00	26239621
2563	Phosphorylation	FDQYRSGSLSLTQFA HHHHHCCCCCHHHHH	18.94	26239621
2565	Phosphorylation	QYRSGSLSLTQFADM HHHCCCCCHHHHHHH	30.94	23737553
2567	Phosphorylation	RSGSLSLTQFADMIS HCCCCCHHHHHHHHH	20.47	23737553
2588	Phosphorylation	NSSGLGGSVNDDVFS CCCCCCCCCCCCCCC	18.89	28973931
2603	Phosphorylation	SSRHDSVSKISTISS CCCCCCCHHHHHHHH	28.37	30352176
2607	Phosphorylation	DSVSKISTISSVRNL CCCHHHHHHHHHHCC	28.49	29472430
2609	Phosphorylation	VSKISTISSVRNLTI CHHHHHHHHHHCCEE	23.91	23737553
2610	Phosphorylation	SKISTISSVRNLTIR HHHHHHHHHHCCEEE	22.65	23737553
2615	Phosphorylation	ISSVRNLTIRSSSLS HHHHHCCEEECCCCC	20.21	23984901
2618	Phosphorylation	VRNLTIRSSSLSDPL HHCCEEECCCCCCCC	22.04	27087446
2619	Phosphorylation	RNLTIRSSSLSDPLE HCCEEECCCCCCCCC	26.00	26239621
2620	Phosphorylation	NLTIRSSSLSDPLEE CCEEECCCCCCCCCC	32.89	27087446
2622	Phosphorylation	TIRSSSLSDPLEESS EEECCCCCCCCCCCC	38.85	27087446
2628	Phosphorylation	LSDPLEESSPIAAIF CCCCCCCCCCEEEEE	31.85	26239621
2629	Phosphorylation	SDPLEESSPIAAIFD CCCCCCCCCEEEEEE	24.49	26239621
2637	Phosphorylation	PIAAIFDTENLEKIS CEEEEEECCCCHHEE	18.94	23140645
2714	Ubiquitination	FIGFEGVKGKKKMSA HHCCCCCCCCCCCCH	75.71	22790023
2726	Ubiquitination	MSAAEAVKEKWLPYE CCHHHHHHHHCCCHH	61.70	22790023
2728	Ubiquitination	AAEAVKEKWLPYEAG HHHHHHHHCCCHHHH	48.60	22790023
2784	Ubiquitination	QDISSYAKILTCPKT HHHHHHHHHHCCCCC	29.98	22790023
2821	Phosphorylation	LLEAASVSSKGLPSP HHHHHHCCCCCCCCC	24.68	23737553
2822	Phosphorylation	LEAASVSSKGLPSPY HHHHHCCCCCCCCCC	28.70	23737553
2823	Ubiquitination	EAASVSSKGLPSPYN HHHHCCCCCCCCCCC	57.89	22790023
2827	Phosphorylation	VSSKGLPSPYNMSAP CCCCCCCCCCCCCCC	45.09	27742792
2829	Phosphorylation	SKGLPSPYNMSAPGS CCCCCCCCCCCCCCC	28.03	26239621
2832	Phosphorylation	LPSPYNMSAPGSRSG CCCCCCCCCCCCCCC	27.89	25521595
2836	Phosphorylation	YNMSAPGSRSGSRSG CCCCCCCCCCCCCCC	23.39	25521595
2837	Methylation	NMSAPGSRSGSRSGS CCCCCCCCCCCCCCC	51.45	24129315
2838	Phosphorylation	MSAPGSRSGSRSGSR CCCCCCCCCCCCCCC	42.70	21183079
2840	Phosphorylation	APGSRSGSRSGSRSG CCCCCCCCCCCCCCC	25.23	21183079
2858	Methylation	GSRSGSRRGSFDATG CCCCCCCCCCEECCC	46.97	24129315
2860	Phosphorylation	RSGSRRGSFDATGNS CCCCCCCCEECCCCC	20.38	22817900
2864	Phosphorylation	RRGSFDATGNSSYSY CCCCEECCCCCCCEE	38.45	-
2879	Phosphorylation	SYSFSSSSIGGY--- EEEEECCCCCCC---	27.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DESP_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2860	S	Phosphorylation	Phosphorylation on Ser-2860 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments (By similarity).	-
2860	S	Phosphorylation	Ser-2860 is probably phosphorylated by a cAMP-dependent protein kinase.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DESP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DESP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.