CALU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALU_MOUSE
• UniProt AC: O35887
• Protein Name: Calumenin
• Gene Name: Calu
• Organism: Mus musculus (Mouse).
• Sequence Length: 315
• Subcellular Localization: Endoplasmic reticulum membrane . Golgi apparatus . Secreted . Melanosome . Sarcoplasmic reticulum lumen .
• Protein Description: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)..
• Protein Sequence: MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQNFDYDHDAFLGAEEAKSFDQLTPEESKERLGKIVSKIDDDKDGFVTVDELKGWIKFAQKRWIHEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	VHHEPQLSDKVHNDA CCCCCCHHHHHCCCH	30.09	22006019
47	Phosphorylation	NDAQNFDYDHDAFLG CCHHCCCCCHHHCCC	15.84	28973931
60	Phosphorylation	LGAEEAKSFDQLTPE CCHHHHHCHHHCCHH	40.89	25619855
65	Phosphorylation	AKSFDQLTPEESKER HHCHHHCCHHHHHHH	24.03	25619855
69	Phosphorylation	DQLTPEESKERLGKI HHCCHHHHHHHHHHH	37.85	25521595
89	Phosphorylation	DDKDGFVTVDELKGW CCCCCCEEHHHHHHH	21.70	26525534
98	Acetylation	DELKGWIKFAQKRWI HHHHHHHHHHHHHCC	28.30	22826441
125	Phosphorylation	LNEDGLVSWEEYKNA CCCCCCCCHHHHCCC	33.54	23984901
129	Phosphorylation	GLVSWEEYKNATYGY CCCCHHHHCCCCEEE	9.68	23984901
131	N-linked_Glycosylation	VSWEEYKNATYGYVL CCHHHHCCCCEEEEC	36.29	-
165	Acetylation	RRFKMADKDGDLIAT HHHCCCCCCCCEEEE	54.81	23806337
196	Phosphorylation	KDIVVQETMEDIDKN HHHHHHHHHHHHHHC	14.58	30352176
254	Phosphorylation	GKMDKEETKDWILPS CCCCHHHHCCCCCCC	35.08	-
261	Phosphorylation	TKDWILPSDYDHAEA HCCCCCCCCCCHHHH	45.41	26525534
263	Phosphorylation	DWILPSDYDHAEAEA CCCCCCCCCHHHHHH	17.61	26525534
275	Phosphorylation	AEARHLVYESDQNKD HHHHHHHHHCCCCCC	18.97	29514104
277	Phosphorylation	ARHLVYESDQNKDGK HHHHHHHCCCCCCCC	27.15	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALU_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALU_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALU_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CA2D1_HUMAN	CACNA2D1	physical	26496610
HBA_HUMAN	HBA1	physical	26496610
SEPT9_HUMAN	SEPT9	physical	26496610
NOM1_HUMAN	NOM1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.