HBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBA_HUMAN
• UniProt AC: P69905
• Protein Name: Hemoglobin subunit alpha
• Gene Name: HBA1
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Protein Description: Involved in oxygen transport from the lung to the various peripheral tissues..
• Protein Sequence: MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVLSPADKTNV ----CCCCHHHCCCC	13.46	23401153
4	O-linked_Glycosylation	----MVLSPADKTNV ----CCCCHHHCCCC	13.46	9402357
8	Acetylation	MVLSPADKTNVKAAW CCCCHHHCCCCHHHH	44.07	7617745
8	Succinylation	MVLSPADKTNVKAAW CCCCHHHCCCCHHHH	44.07	-
8	Glycation	MVLSPADKTNVKAAW CCCCHHHCCCCHHHH	44.07	-
8	N-linked_Glycosylation	MVLSPADKTNVKAAW CCCCHHHCCCCHHHH	44.07	7358733
8	Succinylation	MVLSPADKTNVKAAW CCCCHHHCCCCHHHH	44.07	-
9	Phosphorylation	VLSPADKTNVKAAWG CCCHHHCCCCHHHHH	45.88	24972180
12	Acetylation	PADKTNVKAAWGKVG HHHCCCCHHHHHHCC	34.16	27178108
12	Succinylation	PADKTNVKAAWGKVG HHHCCCCHHHHHHCC	34.16	-
12	Succinylation	PADKTNVKAAWGKVG HHHCCCCHHHHHHCC	34.16	-
17	Glycation	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	-
17	N-linked_Glycosylation	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	7358733
17	Succinylation	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	-
17	Acetylation	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	19608861
17	Succinylation	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	-
17	Ubiquitination	NVKAAWGKVGAHAGE CCHHHHHHCCHHHHH	27.13	-
21	Methylation	AWGKVGAHAGEYGAE HHHHCCHHHHHHHHH	28.47	-
25	Nitration	VGAHAGEYGAEALER CCHHHHHHHHHHHHH	22.25	-
25	Phosphorylation	VGAHAGEYGAEALER CCHHHHHHHHHHHHH	22.25	23911959
36	O-linked_Glycosylation	ALERMFLSFPTTKTY HHHHHHHHCCCCCCC	20.22	9402381
36	Phosphorylation	ALERMFLSFPTTKTY HHHHHHHHCCCCCCC	20.22	23025827
39	Phosphorylation	RMFLSFPTTKTYFPH HHHHHCCCCCCCCCC	38.62	23025827
40	Phosphorylation	MFLSFPTTKTYFPHF HHHHCCCCCCCCCCC	22.94	23025827
41	Ubiquitination	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	-
41	Acetylation	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	26051181
41	Glycation	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	-
41	Succinylation	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	-
41	N-linked_Glycosylation	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	7358733
41	Succinylation	FLSFPTTKTYFPHFD HHHCCCCCCCCCCCC	43.64	-
42	Phosphorylation	LSFPTTKTYFPHFDL HHCCCCCCCCCCCCC	28.44	19060867
43	Nitration	SFPTTKTYFPHFDLS HCCCCCCCCCCCCCC	19.37	-
43	Phosphorylation	SFPTTKTYFPHFDLS HCCCCCCCCCCCCCC	19.37	21253578
50	Phosphorylation	YFPHFDLSHGSAQVK CCCCCCCCCCCEECC	27.87	23025827
53	Phosphorylation	HFDLSHGSAQVKGHG CCCCCCCCEECCCCH	15.31	23025827
57	Ubiquitination	SHGSAQVKGHGKKVA CCCCEECCCCHHHHH	32.86	-
57	Acetylation	SHGSAQVKGHGKKVA CCCCEECCCCHHHHH	32.86	7640557
61	Ubiquitination	AQVKGHGKKVADALT EECCCCHHHHHHHHH	38.10	-
61	Acetylation	AQVKGHGKKVADALT EECCCCHHHHHHHHH	38.10	7612859
62	N-linked_Glycosylation	QVKGHGKKVADALTN ECCCCHHHHHHHHHH	47.44	7358733
62	Glycation	QVKGHGKKVADALTN ECCCCHHHHHHHHHH	47.44	-
62	Acetylation	QVKGHGKKVADALTN ECCCCHHHHHHHHHH	47.44	7824027
68	Phosphorylation	KKVADALTNAVAHVD HHHHHHHHHHHHCCC	23.89	28857561
77	Sulfoxidation	AVAHVDDMPNALSAL HHHCCCCCCHHHHHH	2.08	21192028
82	Phosphorylation	DDMPNALSALSDLHA CCCCHHHHHHHHHHH	25.42	28192239
91	Acetylation	LSDLHAHKLRVDPVN HHHHHHHCCCCCCCC	38.48	27178108
100	Acetylation	RVDPVNFKLLSHCLL CCCCCCHHHHHHHHH	43.23	7664937
103	Phosphorylation	PVNFKLLSHCLLVTL CCCHHHHHHHHHHHH	23.69	22673903
105	S-nitrosocysteine	NFKLLSHCLLVTLAA CHHHHHHHHHHHHHH	2.56	-
105	S-nitrosylation	NFKLLSHCLLVTLAA CHHHHHHHHHHHHHH	2.56	22178444
109	Phosphorylation	LSHCLLVTLAAHLPA HHHHHHHHHHHCCCC	15.62	22673903
119	Phosphorylation	AHLPAEFTPAVHASL HCCCCCCCHHHHHHH	11.22	22673903
125	Phosphorylation	FTPAVHASLDKFLAS CCHHHHHHHHHHHHH	23.40	22673903
132	Phosphorylation	SLDKFLASVSTVLTS HHHHHHHHHHHHHHC	20.81	23025827
134	Phosphorylation	DKFLASVSTVLTSKY HHHHHHHHHHHHCCC	15.42	29691806
134	O-linked_Glycosylation	DKFLASVSTVLTSKY HHHHHHHHHHHHCCC	15.42	9402513
135	Phosphorylation	KFLASVSTVLTSKYR HHHHHHHHHHHCCCC	19.85	23025827
138	Phosphorylation	ASVSTVLTSKYR--- HHHHHHHHCCCC---	20.88	23025827
139	Phosphorylation	SVSTVLTSKYR---- HHHHHHHCCCC----	24.43	23025827
140	Acetylation	VSTVLTSKYR----- HHHHHHCCCC-----	39.55	27178108
141	Phosphorylation	STVLTSKYR------ HHHHHCCCC------	22.71	-
141	Nitration	STVLTSKYR------ HHHHHCCCC------	22.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HBB_HUMAN	HBB	physical	16169070
CRYAB_HUMAN	CRYAB	physical	22815750

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• 140700: Heinz body anemias (HEIBAN)
• 604131: Alpha-thalassemia (A-THAL)
• : Note=Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
• 613978:
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• DB00893: Iron Dextran
• DB00358: Mefloquine

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Sites of nonenzymatic glycosylation of human hemoglobin A.";
Shapiro R., McManus M.J., Zalut C., Bunn H.F.;
J. Biol. Chem. 255:3120-3127(1980).
Cited for: GLYCATION AT LYS-8; LYS-17; LYS-41 AND LYS-62, AND LACK OF GLYCATIONAT LYS-12; LYS-57; LYS-61; LYS-91 AND LYS-100.
PubMed: 7358733

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-25 AND TYR-43, AND MASSSPECTROMETRY.
PubMed: 18083107