KIF2C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF2C_MOUSE
• UniProt AC: Q922S8
• Protein Name: Kinesin-like protein KIF2C
• Gene Name: Kif2c
• Organism: Mus musculus (Mouse).
• Sequence Length: 721
• Subcellular Localization: Cytoplasm, cytoskeleton . Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MA
• Protein Description: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. [PubMed: 14980225 Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity]
• Protein Sequence: MESLHARLFPGLSINIQRSNGLIHPANISTVNVEKSCVSVEWIEGGTTKGKEIDIDDVAAINPELLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALKEGLRSRSTRMSTVSEVRIPAQENEMEVELPVPTNSRKQFAIPSHPRASCSTVTELPLLMVSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSELRIKRAQEYDSSFPNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRTKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQPVQMETEVMEASSNGTSLTGNEEEELSSQMSSFNEAMTQIRELEERALEELREIIQQGPNWLELSEMTDQPDYDLETFVNKAESALTQQAKQAKHFSALREVIKALRLAMQLEEQASKQINSKKRHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESLHARLFP -----CCCHHHHHCC	24.94	-
19	Phosphorylation	LSINIQRSNGLIHPA CEEEEEECCCCEECC	20.90	26370283
76	Phosphorylation	LPLRPKDSLPLQENV CCCCCCCCCCCCCCC	37.70	22817900
92	Phosphorylation	VPKQKRKSVNSKIPA CCCHHHHHHHCCCHH	30.48	29514104
106	Phosphorylation	ALKEGLRSRSTRMST HHHHHHHCCCCCCEE	35.31	-
108	Phosphorylation	KEGLRSRSTRMSTVS HHHHHCCCCCCEEEE	22.93	19367708
112	Phosphorylation	RSRSTRMSTVSEVRI HCCCCCCEEEEEEEC	23.51	28066266
113	Phosphorylation	SRSTRMSTVSEVRIP CCCCCCEEEEEEECC	20.78	28066266
115	Phosphorylation	STRMSTVSEVRIPAQ CCCCEEEEEEECCCC	30.38	28066266
149	Phosphorylation	IPSHPRASCSTVTEL CCCCCCCCCCCCCCC	15.18	25266776
151	Phosphorylation	SHPRASCSTVTELPL CCCCCCCCCCCCCCE	24.34	30482847
162	Phosphorylation	ELPLLMVSEEAEEQA CCCEEEECHHHHHHH	18.76	-
171	Phosphorylation	EAEEQAHSTRSTSSA HHHHHHHHCCCCCCC	28.65	-
183	Phosphorylation	SSANPGNSVRRKSCI CCCCCCCCHHHHHHH	23.94	25266776
188	Phosphorylation	GNSVRRKSCIVKEME CCCHHHHHHHHHHHH	13.78	28066266
351	Phosphorylation	GQTGSGKTHTMGGDL CCCCCCCCEECCCCC	26.55	22871156
362	Phosphorylation	GGDLSGKSQNASKGI CCCCCCCCCCCCCCE	31.99	27149854
366	Phosphorylation	SGKSQNASKGIYAMA CCCCCCCCCCEEEEE	38.68	27149854
454	Phosphorylation	MGSACRTSGQTFANS CCCCHHCCCCCCCCC	15.00	-
498	Phosphorylation	GNERGADTSSADRQT CCCCCCCCCHHHHHH	24.85	-
499	Phosphorylation	NERGADTSSADRQTR CCCCCCCCHHHHHHH	24.87	-
515	Phosphorylation	EGAEINKSLLALKEC CHHHHHHHHHHHHHH	24.91	25159016
520	Ubiquitination	NKSLLALKECIRALG HHHHHHHHHHHHHHC	44.95	-
547	Phosphorylation	LTQVLRDSFIGENSR HHHHHHHHCCCCCCC	16.60	-
626	Phosphorylation	ELSSQMSSFNEAMTQ HHHHHHHHHHHHHHH	27.09	-
711	Phosphorylation	MQLEEQASKQINSKK HHHHHHHHHHHHHHH	25.45	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
92	S	Phosphorylation	Kinase	AURKB	O70126	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF2C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF2C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPC_HUMAN	CENPC	physical	26496610
EXT1_HUMAN	EXT1	physical	26496610
RT12_HUMAN	MRPS12	physical	26496610
B3A2_HUMAN	SLC4A2	physical	26496610
TBA1A_HUMAN	TUBA1A	physical	26496610
YMEL1_HUMAN	YME1L1	physical	26496610
ZN273_HUMAN	ZNF273	physical	26496610
NPIB3_HUMAN	NPIPB3	physical	26496610
TBCD7_HUMAN	TBC1D7	physical	26496610
DEP1A_HUMAN	DEPDC1	physical	26496610
ERGI1_HUMAN	ERGIC1	physical	26496610
TPC13_HUMAN	TRAPPC13	physical	26496610
RN170_HUMAN	RNF170	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.