NPIB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPIB3_HUMAN
• UniProt AC: Q92617
• Protein Name: Nuclear pore complex-interacting protein family member B3
• Gene Name: NPIPB3
• Organism: Homo sapiens (Human).
• Sequence Length: 1050
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTALPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVKLSIVLTPQF ---CCEEEEEECHHH		29083192
9	Phosphorylation	VKLSIVLTPQFLSHD CEEEEEECHHHHCCC		24043423
14	Phosphorylation	VLTPQFLSHDQGQLT EECHHHHCCCCCHHH		24043423
21	Phosphorylation	SHDQGQLTKELQQHV CCCCCHHHHHHHHHH		24043423
85	Phosphorylation	WIVYLWVSLLKTIFW HHHHHHHHHHHHHHH		24719451
151	Phosphorylation	TLRRHVETKVRAKIR HHHHHHHHHHHHHHH		-
152	Acetylation	LRRHVETKVRAKIRK HHHHHHHHHHHHHHC		30590885
225	Phosphorylation	AAAEHRHSSGLPYWP HHHHHHHHCCCCCHH		25693802
226	Phosphorylation	AAEHRHSSGLPYWPY HHHHHHHCCCCCHHH		25693802
230	Phosphorylation	RHSSGLPYWPYLTAE HHHCCCCCHHHCCHH		25693802
233	Phosphorylation	SGLPYWPYLTAETLK CCCCCHHHCCHHHHH		25693802
251	Phosphorylation	GHQPPPPTQQHSITD CCCCCCCCCCCCCCC		25693802
255	Phosphorylation	PPPTQQHSITDNSLS CCCCCCCCCCCCCCC		30622161
257	Phosphorylation	PTQQHSITDNSLSLK CCCCCCCCCCCCCCC		25693802
260	Phosphorylation	QHSITDNSLSLKTPP CCCCCCCCCCCCCCC		24719451
262	Phosphorylation	SITDNSLSLKTPPEC CCCCCCCCCCCCCHH		24719451
322	Phosphorylation	SADDNLKTPPECLLT CCCCCCCCCCHHHCC		-
341	Phosphorylation	SADDNLKTPPECLLT CCCCCCCCCCHHHCC		-
394	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
399	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
403	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
436	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
441	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
445	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
478	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
483	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
487	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
558	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
563	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
567	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
590	Phosphorylation	IISRHLPSVSSLPFH HHHCCCCCCHHCCCC		28842319
632	Phosphorylation	IISRHLPSVSSLPFH HHHCCCCCCHHCCCC		28842319
674	Phosphorylation	IISRHLPSVSSLPFH EEECCCCCCHHCCCC		28842319
716	Phosphorylation	IISRHLPSVSSLPFH HHHCCCCCCHHCCCC		28842319
758	Phosphorylation	IISRHLPSVSSLPFH EEECCCCCCHHCCCC		28842319
808	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
813	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
817	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
850	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
855	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
859	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
892	Phosphorylation	TPSERQLTPLPPSAP CCCHHCCCCCCCCCC		-
897	Phosphorylation	QLTPLPPSAPPSADD CCCCCCCCCCCCCCC		-
901	Phosphorylation	LPPSAPPSADDNIKT CCCCCCCCCCCCCCC		-
954 (in isoform 6)	Phosphorylation	-		-
955 (in isoform 6)	Phosphorylation	-		-
982	Phosphorylation	RAADVEPSSPEPKRR CCCCCCCCCCCCCCC		29255136
983	Phosphorylation	AADVEPSSPEPKRRR CCCCCCCCCCCCCCC		23401153
1011	Phosphorylation	RAADVEPSSPEPKRR CCCCCCCCCCCCCCC		29255136
1012	Phosphorylation	AADVEPSSPEPKRRR CCCCCCCCCCCCCCC		23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPIB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPIB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPIB3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NPIB3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.