dbPTM

CENPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CENPC_HUMAN
UniProt AC	Q03188
Protein Name	Centromere protein C
Gene Name	CENPC
Organism	Homo sapiens (Human).
Sequence Length	943
Subcellular Localization	Nucleus . Chromosome, centromere, kinetochore . Chromosome, centromere . Localizes exclusively in the kinetochore domain of centromeres.
Protein Description	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions..
Protein Sequence	MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	ASGLDHLKNGYRRRF CCCHHHHHCCCCCCC	44.93	21890473
10	Ubiquitination	ASGLDHLKNGYRRRF CCCHHHHHCCCCCCC	44.93	21890473
10	Ubiquitination	ASGLDHLKNGYRRRF CCCHHHHHCCCCCCC	44.93	21890473
45	Sumoylation	LQDCFEEKSLANDFS HHHHHHHHHHHCCCC	43.50	28112733
45	Ubiquitination	LQDCFEEKSLANDFS HHHHHHHHHHHCCCC	43.50	29967540
46	Phosphorylation	QDCFEEKSLANDFST HHHHHHHHHHCCCCC	35.67	19691289
52	Phosphorylation	KSLANDFSTNSTKSV HHHHCCCCCCCCCCC	29.55	25159151
53	Phosphorylation	SLANDFSTNSTKSVP HHHCCCCCCCCCCCC	32.93	30266825
55	Phosphorylation	ANDFSTNSTKSVPNS HCCCCCCCCCCCCCC	36.98	30266825
56	Phosphorylation	NDFSTNSTKSVPNST CCCCCCCCCCCCCCC	29.43	30266825
62	Phosphorylation	STKSVPNSTRKIKDT CCCCCCCCCCHHHHH	24.42	20860994
69	Phosphorylation	STRKIKDTCIQSPSK CCCHHHHHHCCCCCH	13.40	30266825
73	Phosphorylation	IKDTCIQSPSKECQK HHHHHCCCCCHHHHH	15.95	29255136
75	Phosphorylation	DTCIQSPSKECQKSH HHHCCCCCHHHHHHC	46.46	30266825
84	Ubiquitination	ECQKSHPKSVPVSSK HHHHHCCCCCCCCCC	59.67	29967540
85	Phosphorylation	CQKSHPKSVPVSSKK HHHHCCCCCCCCCCC	35.78	27251275
89	Phosphorylation	HPKSVPVSSKKKEAS CCCCCCCCCCCCCEE	30.30	30266825
90	Phosphorylation	PKSVPVSSKKKEASL CCCCCCCCCCCCEEE	49.05	30266825
96	Phosphorylation	SSKKKEASLQFVVEP CCCCCCEEEEEEECC	24.64	30266825
104	Phosphorylation	LQFVVEPSEATNRSV EEEEECCHHHCCCCC	26.76	26074081
107	Phosphorylation	VVEPSEATNRSVQAH EECCHHHCCCCCHHH	27.41	26074081
110	Phosphorylation	PSEATNRSVQAHEVH CHHHCCCCCHHHHHH	22.20	30266825
119	Sumoylation	QAHEVHQKILATDVS HHHHHHHHHHHHCCC	25.47	28112733
119	Ubiquitination	QAHEVHQKILATDVS HHHHHHHHHHHHCCC	25.47	21890473
119	Ubiquitination	QAHEVHQKILATDVS HHHHHHHHHHHHCCC	25.47	21890473
119	Ubiquitination	QAHEVHQKILATDVS HHHHHHHHHHHHCCC	25.47	21890473
123	Phosphorylation	VHQKILATDVSSKNT HHHHHHHHCCCCCCC	33.22	30266825
126	Phosphorylation	KILATDVSSKNTPDS HHHHHCCCCCCCCCC	38.10	30266825
127	Phosphorylation	ILATDVSSKNTPDSK HHHHCCCCCCCCCCC	29.76	30266825
128	Ubiquitination	LATDVSSKNTPDSKK HHHCCCCCCCCCCCC	58.28	33845483
130	Phosphorylation	TDVSSKNTPDSKKIS HCCCCCCCCCCCCCC	32.01	29255136
133	Phosphorylation	SSKNTPDSKKISSRN CCCCCCCCCCCCCCC	36.73	30266825
134	Sumoylation	SKNTPDSKKISSRNI CCCCCCCCCCCCCCC	62.60	28112733
146	Phosphorylation	RNINDHHSEADEEFY CCCCCCCCCCCCCEE	30.93	30266825
153	Phosphorylation	SEADEEFYLSVGSPS CCCCCCEEEECCCCE	11.01	30266825
155	Phosphorylation	ADEEFYLSVGSPSVL CCCCEEEECCCCEEE	17.04	30266825
158	Phosphorylation	EFYLSVGSPSVLLDA CEEEECCCCEEEEEC	16.31	25849741
160	Phosphorylation	YLSVGSPSVLLDAKT EEECCCCEEEEECCC	27.39	20068231
167	Phosphorylation	SVLLDAKTSVSQNVI EEEEECCCCCCCCCC	35.76	30266825
168	Phosphorylation	VLLDAKTSVSQNVIP EEEECCCCCCCCCCC	21.04	30266825
170	Phosphorylation	LDAKTSVSQNVIPSS EECCCCCCCCCCCCC	18.79	30266825
176	Phosphorylation	VSQNVIPSSAQKRET CCCCCCCCCCCCCCE	27.47	23401153
177	Phosphorylation	SQNVIPSSAQKRETY CCCCCCCCCCCCCEE	29.39	25159151
180	Sumoylation	VIPSSAQKRETYTFE CCCCCCCCCCEEEEE	52.50	28112733
180	Ubiquitination	VIPSSAQKRETYTFE CCCCCCCCCCEEEEE	52.50	29967540
183	Phosphorylation	SSAQKRETYTFENSV CCCCCCCEEEEECCE	31.71	23401153
184	Phosphorylation	SAQKRETYTFENSVN CCCCCCEEEEECCEE	12.51	23401153
185	Phosphorylation	AQKRETYTFENSVNM CCCCCEEEEECCEEC	31.71	23401153
189	Phosphorylation	ETYTFENSVNMLPSS CEEEEECCEECCCCC	13.99	23401153
195	Phosphorylation	NSVNMLPSSTEVSVK CCEECCCCCCEEEHH	46.03	30266825
196	Phosphorylation	SVNMLPSSTEVSVKT CEECCCCCCEEEHHC	27.01	30266825
197	Phosphorylation	VNMLPSSTEVSVKTK EECCCCCCEEEHHCC	44.75	30266825
200	Phosphorylation	LPSSTEVSVKTKKRL CCCCCEEEHHCCCCC	16.21	23401153
212	Sumoylation	KRLNFDDKVMLKKIE CCCCCCCCEEEEEEE	31.24	28112733
217	Sumoylation	DDKVMLKKIEIDNKV CCCEEEEEEEECCCC	41.43	25755297
225	Phosphorylation	IEIDNKVSDEEDKTS EEECCCCCCCCCCCC	40.70	29255136
231	Phosphorylation	VSDEEDKTSEGQERK CCCCCCCCCCCCCCC	44.31	29255136
232	Phosphorylation	SDEEDKTSEGQERKP CCCCCCCCCCCCCCC	45.53	29255136
238	Sumoylation	TSEGQERKPSGSSQN CCCCCCCCCCCCCCC	42.66	28112733
240	Phosphorylation	EGQERKPSGSSQNRI CCCCCCCCCCCCCHH	55.10	-
243	Phosphorylation	ERKPSGSSQNRIRDS CCCCCCCCCCHHCCC	34.69	-
250	Phosphorylation	SQNRIRDSEYEIQRQ CCCHHCCCHHHHHHH	32.03	25159151
252	Phosphorylation	NRIRDSEYEIQRQAK CHHCCCHHHHHHHHH	23.45	27642862
259	Ubiquitination	YEIQRQAKKSFSTLF HHHHHHHHHHHHHHH	40.38	23000965
260	Sumoylation	EIQRQAKKSFSTLFL HHHHHHHHHHHHHHH	60.80	28112733
260	Ubiquitination	EIQRQAKKSFSTLFL HHHHHHHHHHHHHHH	60.80	23000965
261	Phosphorylation	IQRQAKKSFSTLFLE HHHHHHHHHHHHHHH	24.59	21712546
263	Phosphorylation	RQAKKSFSTLFLETV HHHHHHHHHHHHHHH	31.15	28450419
264	Phosphorylation	QAKKSFSTLFLETVK HHHHHHHHHHHHHHH	21.37	18669648
271	Sumoylation	TLFLETVKRKSESSP HHHHHHHHHHCCCCC	62.62	28112733
271	Ubiquitination	TLFLETVKRKSESSP HHHHHHHHHHCCCCC	62.62	23000965
273	Sumoylation	FLETVKRKSESSPIV HHHHHHHHCCCCCCC	53.51	28112733
273	Ubiquitination	FLETVKRKSESSPIV HHHHHHHHCCCCCCC	53.51	23000965
274	Phosphorylation	LETVKRKSESSPIVR HHHHHHHCCCCCCCC	46.90	24732914
276	Phosphorylation	TVKRKSESSPIVRHA HHHHHCCCCCCCCCC	48.80	19691289
277	Phosphorylation	VKRKSESSPIVRHAA HHHHCCCCCCCCCCC	18.00	29255136
290	Phosphorylation	AATAPPHSCPPDDTK CCCCCCCCCCCCCCC	33.81	25159151
296	Phosphorylation	HSCPPDDTKLIEDEF CCCCCCCCCCCCCEE	34.82	25159151
297	Sumoylation	SCPPDDTKLIEDEFI CCCCCCCCCCCCEEE	55.23	28112733
308	Phosphorylation	DEFIIDESDQSFASR CEEEECCCCCCCHHC	36.88	30266825
311	Phosphorylation	IIDESDQSFASRSWI EECCCCCCCHHCCCE	27.98	30266825
314	Phosphorylation	ESDQSFASRSWITIP CCCCCCHHCCCEEEE	25.49	23663014
316	Phosphorylation	DQSFASRSWITIPRK CCCCHHCCCEEEECC	21.97	30266825
319	Phosphorylation	FASRSWITIPRKAGS CHHCCCEEEECCCCC	20.76	29396449
331	Phosphorylation	AGSLKQRTISPAEST CCCCCCCCCCHHHHH	24.26	29255136
333	Phosphorylation	SLKQRTISPAESTAL CCCCCCCCHHHHHHH	19.90	23401153
337	Phosphorylation	RTISPAESTALLQGR CCCCHHHHHHHHCCC	22.53	24732914
338	Phosphorylation	TISPAESTALLQGRK CCCHHHHHHHHCCCC	16.90	24732914
349	Ubiquitination	QGRKSREKHHNILPK CCCCCHHHHCCCCCC	49.40	29967540
356	Ubiquitination	KHHNILPKTLANDKH HHCCCCCCCCCCCCC	53.37	29967540
364	Phosphorylation	TLANDKHSHKPHPVE CCCCCCCCCCCCCCC	38.66	29449344
372	Phosphorylation	HKPHPVETSQPSDKT CCCCCCCCCCCCCCC	32.66	29496963
373	Phosphorylation	KPHPVETSQPSDKTV CCCCCCCCCCCCCCE	26.96	30108239
376	Phosphorylation	PVETSQPSDKTVLDT CCCCCCCCCCCEEEC	44.07	30108239
379	Phosphorylation	TSQPSDKTVLDTSYA CCCCCCCCEEECHHH	31.15	30576142
383	Phosphorylation	SDKTVLDTSYALIGE CCCCEEECHHHHHCH	21.34	30108239
384	Phosphorylation	DKTVLDTSYALIGET CCCEEECHHHHHCHH	14.21	25159151
385	Phosphorylation	KTVLDTSYALIGETV CCEEECHHHHHCHHH	13.91	30576142
391	Phosphorylation	SYALIGETVNNYRST HHHHHCHHHHCHHHH	24.26	29396449
395	Phosphorylation	IGETVNNYRSTKYEM HCHHHHCHHHHHHCH	10.75	26074081
397	Phosphorylation	ETVNNYRSTKYEMYS HHHHCHHHHHHCHHC	20.92	29083192
398	Phosphorylation	TVNNYRSTKYEMYSK HHHCHHHHHHCHHCC	28.75	29083192
399	Acetylation	VNNYRSTKYEMYSKN HHCHHHHHHCHHCCC	40.22	25953088
399	Ubiquitination	VNNYRSTKYEMYSKN HHCHHHHHHCHHCCC	40.22	23000965
400	Phosphorylation	NNYRSTKYEMYSKNA HCHHHHHHCHHCCCC	13.15	23612710
403	Phosphorylation	RSTKYEMYSKNAEKP HHHHHCHHCCCCCCC	12.45	29083192
404	Phosphorylation	STKYEMYSKNAEKPS HHHHCHHCCCCCCCC	20.37	24719451
405	Ubiquitination	TKYEMYSKNAEKPSR HHHCHHCCCCCCCCC	42.56	23000965
414	Methylation	AEKPSRSKRTIKQKQ CCCCCCCCCHHHHHH	53.07	-
439	Phosphorylation	EQLDVGQSKDENIHT HHCCCCCCCCCCCCC	35.82	29255136
440	Sumoylation	QLDVGQSKDENIHTS HCCCCCCCCCCCCCC	62.26	28112733
440	Ubiquitination	QLDVGQSKDENIHTS HCCCCCCCCCCCCCC	62.26	29967540
446	Phosphorylation	SKDENIHTSHITQDE CCCCCCCCCCCCHHH	20.43	23401153
447	Phosphorylation	KDENIHTSHITQDEF CCCCCCCCCCCHHHH	9.95	29255136
450	Phosphorylation	NIHTSHITQDEFQRN CCCCCCCCHHHHHHC	25.25	28387310
483	Phosphorylation	KQMPPVGSKKSSTRK CCCCCCCCCCCCCCC	36.82	-
501	Phosphorylation	ESKKKRFSSESKNKL HHHHHCCCHHHHCCC	36.91	26425664
502	Phosphorylation	SKKKRFSSESKNKLV HHHHCCCHHHHCCCC	43.08	26425664
505	Ubiquitination	KRFSSESKNKLVPEE HCCCHHHHCCCCCHH	54.79	23000965
507	Ubiquitination	FSSESKNKLVPEEVT CCHHHHCCCCCHHHH	55.38	23000965
514	Phosphorylation	KLVPEEVTSTVTKSR CCCCHHHHHHHHHCC	23.20	29255136
515	Phosphorylation	LVPEEVTSTVTKSRR CCCHHHHHHHHHCCC	26.51	29255136
516	Phosphorylation	VPEEVTSTVTKSRRI CCHHHHHHHHHCCCC	23.87	29255136
518	Phosphorylation	EEVTSTVTKSRRISR HHHHHHHHHCCCCCC	24.32	29255136
519	Ubiquitination	EVTSTVTKSRRISRR HHHHHHHHCCCCCCC	37.31	33845483
520	Phosphorylation	VTSTVTKSRRISRRP HHHHHHHCCCCCCCC	19.89	21712546
524	Phosphorylation	VTKSRRISRRPSDWW HHHCCCCCCCCCCCE	22.04	23882029
528	Phosphorylation	RRISRRPSDWWVVKS CCCCCCCCCCEEEEC	44.01	25159151
534	Sumoylation	PSDWWVVKSEESPVY CCCCEEEECCCCCCC	42.40	-
534	Sumoylation	PSDWWVVKSEESPVY CCCCEEEECCCCCCC	42.40	15272016
535	Phosphorylation	SDWWVVKSEESPVYS CCCEEEECCCCCCCC	34.68	30266825
538	Phosphorylation	WVVKSEESPVYSNSS EEEECCCCCCCCCCH	18.66	25159151
541	Phosphorylation	KSEESPVYSNSSVRN ECCCCCCCCCCHHHH	12.91	28176443
542	Phosphorylation	SEESPVYSNSSVRNE CCCCCCCCCCHHHHC	30.39	30266825
544	Phosphorylation	ESPVYSNSSVRNELP CCCCCCCCHHHHCCC	25.03	29396449
545	Phosphorylation	SPVYSNSSVRNELPM CCCCCCCHHHHCCCC	29.37	29396449
556	Phosphorylation	ELPMHHNSSRKSTKK CCCCCCCCCCCCCCC	27.45	27732954
557	Phosphorylation	LPMHHNSSRKSTKKT CCCCCCCCCCCCCCC	49.39	27732954
560	Phosphorylation	HHNSSRKSTKKTNQS CCCCCCCCCCCCCCC	44.33	23322592
561	Phosphorylation	HNSSRKSTKKTNQSS CCCCCCCCCCCCCCC	39.33	23322592
568	O-linked_Glycosylation	TKKTNQSSKNIRKKT CCCCCCCCCCHHHCC	21.69	30379171
575	Phosphorylation	SKNIRKKTIPLKRQK CCCHHHCCCCCCCCC	30.75	24719451
579	Acetylation	RKKTIPLKRQKTATK HHCCCCCCCCCCCCC	47.64	30587581
593	Ubiquitination	KGNQRVQKFLNAEGS CHHHHHHHHHHCCCC	49.30	29967540
600	Phosphorylation	KFLNAEGSGGIVGHD HHHHCCCCCCCCCCC	25.92	30266825
610	Phosphorylation	IVGHDEISRCSLSEP CCCCCCCCCCCCCCC	25.78	30266825
613	Phosphorylation	HDEISRCSLSEPLES CCCCCCCCCCCCCCC	33.54	23401153
615	Phosphorylation	EISRCSLSEPLESDE CCCCCCCCCCCCCCH	22.37	30266825
620	Phosphorylation	SLSEPLESDEADLAK CCCCCCCCCHHHHHH	48.73	30266825
634	Phosphorylation	KKKNLDCSRSTRSSK HHHCCCCCCCCCCCC	29.00	24702127
648	Phosphorylation	KNEDNIMTAQNVPLK CCHHCCCCCCCCCCC	22.69	29978859
655	Ubiquitination	TAQNVPLKPQTSGYT CCCCCCCCCCCCCCE	29.07	29967540
661	Phosphorylation	LKPQTSGYTCNIPTE CCCCCCCCEEECCCC	14.11	29449344
662	Phosphorylation	KPQTSGYTCNIPTES CCCCCCCEEECCCCC	11.55	29449344
667	Phosphorylation	GYTCNIPTESNLDSG CCEEECCCCCCCCCC	48.53	28348404
669	Phosphorylation	TCNIPTESNLDSGEH EEECCCCCCCCCCCC	45.21	25159151
673	Phosphorylation	PTESNLDSGEHKTSV CCCCCCCCCCCCCHH	49.61	25849741
677	Sumoylation	NLDSGEHKTSVLEES CCCCCCCCCHHHHHC	37.89	28112733
678	Phosphorylation	LDSGEHKTSVLEESG CCCCCCCCHHHHHCC	26.44	25159151
679	Phosphorylation	DSGEHKTSVLEESGP CCCCCCCHHHHHCCC	29.52	21815630
684	Phosphorylation	KTSVLEESGPSRLNN CCHHHHHCCCCCCCC	46.78	25159151
687	Phosphorylation	VLEESGPSRLNNNYL HHHHCCCCCCCCCEE	53.58	30108239
693	Phosphorylation	PSRLNNNYLMSGKND CCCCCCCEECCCCCC	13.10	23898821
696	Phosphorylation	LNNNYLMSGKNDVDD CCCCEECCCCCCCCC	43.98	24719451
709	Phosphorylation	DDEEVHGSSDDSKQS CCCCCCCCCCCHHHC	18.73	23401153
710	Phosphorylation	DEEVHGSSDDSKQSK CCCCCCCCCCHHHCC	50.45	23401153
713	Phosphorylation	VHGSSDDSKQSKVIP CCCCCCCHHHCCCCC	37.27	25159151
716	Phosphorylation	SSDDSKQSKVIPKNR CCCCHHHCCCCCCCC	32.40	28176443
721	Sumoylation	KQSKVIPKNRIHHKL HHCCCCCCCCCCEEE	47.97	-
721	Sumoylation	KQSKVIPKNRIHHKL HHCCCCCCCCCCEEE	47.97	15272016
727	Sumoylation	PKNRIHHKLVLPSNT CCCCCCEEEECCCCC	26.57	28112733
727	Ubiquitination	PKNRIHHKLVLPSNT CCCCCCEEEECCCCC	26.57	21890473
727	Ubiquitination	PKNRIHHKLVLPSNT CCCCCCEEEECCCCC	26.57	21890473
727	Ubiquitination	PKNRIHHKLVLPSNT CCCCCCEEEECCCCC	26.57	21890473
732	Phosphorylation	HHKLVLPSNTPNVRR CEEEECCCCCCCCCC	49.53	30266825
734	Phosphorylation	KLVLPSNTPNVRRTK EEECCCCCCCCCCCC	22.15	30266825
740	Phosphorylation	NTPNVRRTKRTRLKP CCCCCCCCCCCCCCC	17.83	29514088
741	Ubiquitination	TPNVRRTKRTRLKPL CCCCCCCCCCCCCCC	50.38	23000965
743	O-linked_Glycosylation	NVRRTKRTRLKPLEY CCCCCCCCCCCCCHH	41.74	30379171
746	Sumoylation	RTKRTRLKPLEYWRG CCCCCCCCCCHHHCC	44.24	-
746	Sumoylation	RTKRTRLKPLEYWRG CCCCCCCCCCHHHCC	44.24	15272016
746	Ubiquitination	RTKRTRLKPLEYWRG CCCCCCCCCCHHHCC	44.24	21890473
746	Ubiquitination	RTKRTRLKPLEYWRG CCCCCCCCCCHHHCC	44.24	21890473
746	Ubiquitination	RTKRTRLKPLEYWRG CCCCCCCCCCHHHCC	44.24	21890473
750	Phosphorylation	TRLKPLEYWRGERID CCCCCCHHHCCCCCC	14.21	-
758	Phosphorylation	WRGERIDYQGRPSGG HCCCCCCCCCCCCCC	15.53	28450419
763	Phosphorylation	IDYQGRPSGGFVISG CCCCCCCCCCEEEEC	50.62	26055452
769	Phosphorylation	PSGGFVISGVLSPDT CCCCEEEECCCCHHH	19.97	30266825
773	Phosphorylation	FVISGVLSPDTISSK EEEECCCCHHHHCCH	20.51	30266825
776	Phosphorylation	SGVLSPDTISSKRKA ECCCCHHHHCCHHHH	26.58	30266825
778	Phosphorylation	VLSPDTISSKRKAKE CCCHHHHCCHHHHHH	31.72	30266825
779	Phosphorylation	LSPDTISSKRKAKEN CCHHHHCCHHHHHHH	32.40	30266825
807	Sumoylation	CLDNDERKTNLMVNL ECCCCHHHHCEEEEC	39.45	28112733
807	Ubiquitination	CLDNDERKTNLMVNL ECCCCHHHHCEEEEC	39.45	29967540
807	Ubiquitination	CLDNDERKTNLMVNL ECCCCHHHHCEEEEC	39.45	21890473
807	Ubiquitination	CLDNDERKTNLMVNL ECCCCHHHHCEEEEC	39.45	21890473
808	Phosphorylation	LDNDERKTNLMVNLG CCCCHHHHCEEEECC	39.54	24719451
825	Phosphorylation	LGDPLQPTRVKDPET CCCCCCCCCCCCHHC	34.82	24719451
860	Ubiquitination	HGELKVYKTLDTPFF CCEEEEEEECCCCCC	45.67	29967540
871	Acetylation	TPFFSTGKLILGPQE CCCCCCCCEEECCCH	32.23	26051181
871	Ubiquitination	TPFFSTGKLILGPQE CCCCCCCCEEECCCH	32.23	29967540
880	Acetylation	ILGPQEEKGKQHVGQ EECCCHHHCCCCCCC	71.32	26051181
880	Ubiquitination	ILGPQEEKGKQHVGQ EECCCHHHCCCCCCC	71.32	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CENPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CENPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAXX_HUMAN	DAXX	physical	9645950
UBF1_HUMAN	UBTF	physical	8702533
ELOC_HUMAN	TCEB1	physical	21988832
MIS12_HUMAN	MIS12	physical	28514442
DSN1_HUMAN	DSN1	physical	28514442
NDC80_HUMAN	NDC80	physical	28514442
PMF1_HUMAN	PMF1	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
NUF2_HUMAN	NUF2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CENPC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; THR-183; SER-189;SER-333; SER-538; SER-763 AND SER-773, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261; SER-316; SER-763AND SER-773, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-225; SER-277;SER-316; SER-333; SER-439; SER-538; SER-600 AND SER-684, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167; SER-170; SER-177;SER-316; SER-333 AND SER-538, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-520 ANDSER-524, AND MASS SPECTROMETRY.	17081983 [Abstract]