| UniProt ID | MIS12_HUMAN | |
|---|---|---|
| UniProt AC | Q9H081 | |
| Protein Name | Protein MIS12 homolog | |
| Gene Name | MIS12 {ECO:0000312|HGNC:HGNC:24967} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 205 | |
| Subcellular Localization | Chromosome, centromere, kinetochore . Associated with the kinetochore. | |
| Protein Description | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. [PubMed: 12515822] | |
| Protein Sequence | MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Phosphorylation | GIPDCDISPVQIRKC CCCCCCCCCHHHHHC | 13.03 | 25159151 | |
| 80 | Phosphorylation | GHFDNLFSKMEQLFL CCHHHHHHHHHHHHH | 33.97 | 24719451 | |
| 119 | Ubiquitination | EDFQHLQKEIEQLQE HHHHHHHHHHHHHHH | 68.00 | - | |
| 129 | Ubiquitination | EQLQEKYKTELCTKQ HHHHHHHHHHHHHHH | 46.74 | - | |
| 135 | Ubiquitination | YKTELCTKQALLAEL HHHHHHHHHHHHHHH | 32.36 | - | |
| 146 | Ubiquitination | LAELEEQKIVQAKLK HHHHHHHHHHHHHHH | 48.39 | - | |
| 151 | Ubiquitination | EQKIVQAKLKQTLTF HHHHHHHHHHHHHHH | 38.84 | - | |
| 180 | Phosphorylation | DFRESLVSLVQNSRK HHHHHHHHHHHHHHH | 28.28 | 25627689 | |
| 185 | Phosphorylation | LVSLVQNSRKLQNIR HHHHHHHHHHHHHHH | 17.44 | 25627689 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIS12_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIS12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIS12_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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