dbPTM

CDC7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDC7_MOUSE
UniProt AC	Q9Z0H0
Protein Name	Cell division cycle 7-related protein kinase
Gene Name	Cdc7
Organism	Mus musculus (Mouse).
Sequence Length	564
Subcellular Localization	Nucleus.
Protein Description	Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3..
Protein Sequence	MEEPMAFSSLRGSDRCPADDSLKKYEQSVKLSGIKRDIEELCEAVPQLVNVFKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSRPAPKTVDQQCTPKTSVKRSYTQVHIKQGKDGKERSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETARSCPAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFFKDMCS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEEPMAFSSLRGSDR CCCCCCCCCCCCCCC	20.94	28066266
9	Phosphorylation	EEPMAFSSLRGSDRC CCCCCCCCCCCCCCC	18.68	28066266
21	Phosphorylation	DRCPADDSLKKYEQS CCCCCCHHHHHHHHH	42.51	-
291	Phosphorylation	FNIHSSISHESPAEK EECCCCCCCCCHHHH	24.13	28066266
294	Phosphorylation	HSSISHESPAEKLIK CCCCCCCCHHHHHHH	24.80	28066266
367	Phosphorylation	QVAPRAGTPGFRAPE CCCCCCCCCCCCCHH	21.18	21454597
377	Phosphorylation	FRAPEVLTKCPDQTT CCCHHHHHCCCCCCC	35.46	21454597
499	Phosphorylation	QAAQAQHSEDSLYKR HHHHHHCCCCCCCCC	30.90	25159016
502	Phosphorylation	QAQHSEDSLYKRDND HHHCCCCCCCCCCCC	29.55	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDC7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDC7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDC7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CDC7_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDC7_MOUSE

Related Literatures of Post-Translational Modification