ABC8B_MOUSE - dbPTM
ABC8B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABC8B_MOUSE
UniProt AC Q8K440
Protein Name ATP-binding cassette sub-family A member 8-B
Gene Name Abca8b
Organism Mus musculus (Mouse).
Sequence Length 1620
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description ATP-dependent lipophilic drug transporter..
Protein Sequence MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13S-palmitoylationISVRQQTCALLQKNL
HHHHHHHHHHHHHHH		1.8728526873
147PhosphorylationFDQRIPTSRELRDHN
ECCCCCCCHHHHHCC		20.5728059163
476UbiquitinationVSPEFHGKESIRIRN
CCHHHCCCCCEEEEE		39.45-
562S-palmitoylationILRIAGVCPQANVQF
HHHHHCCCCCCCCEE		1.7028526873
621UbiquitinationQNLSGGQKRKLTFGI
HHCCCCCCCEEEEEE		55.57-
684UbiquitinationADILADRKVFISNGR
HHHHHCCEEEEECCC		41.88-
688PhosphorylationADRKVFISNGRLKCA
HCCEEEEECCCEEEC		23.0528059163
693UbiquitinationFISNGRLKCAGSSLF
EEECCCEEECCCEEE		22.22-
723N-linked_GlycosylationKEVCVPENITSLVKQ
EECCCCCCHHHHHHH		36.45-
792UbiquitinationVFLKLEGKASIDEPE
HHHHHCCCCCCCCCC		29.59-
811PhosphorylationGEGQTERSGDTERLM
CCCCCCCCCCHHHHH		34.4930352176
825PhosphorylationMEMEQTLSSLRETEK
HHHHHHHHHHHHHHC		30.6225159016
826PhosphorylationEMEQTLSSLRETEKT
HHHHHHHHHHHHHCC		34.2625159016
1282S-palmitoylationKPVIIASCLRKEYAG
CCEEEEEHHCHHHCC		2.9328526873
1313UbiquitinationNVSFCVRKGEILGLL
CEEEEEECCCEEEEE		40.26-
1313AcetylationNVSFCVRKGEILGLL
CEEEEEECCCEEEEE		40.267614423
1327AcetylationLGHNGAGKSTSLKMI
ECCCCCCCCCEEEEE		50.457614433
1328PhosphorylationGHNGAGKSTSLKMIS
CCCCCCCCCEEEEEC		23.4725293948
1329PhosphorylationHNGAGKSTSLKMISG
CCCCCCCCEEEEECC		41.3825293948
1330PhosphorylationNGAGKSTSLKMISGD
CCCCCCCEEEEECCC		32.8425293948
1335PhosphorylationSTSLKMISGDTKVTA
CCEEEEECCCCEEEC		27.4151457245
1348UbiquitinationTAGQVLLKGSREGDT
ECCEEEECCCCCCCC		51.16-
1390PhosphorylationAVRGLRKSHAAVAIT
HHHHHHHHHHHHHHH		16.3625619855
1397PhosphorylationSHAAVAITRLADALK
HHHHHHHHHHHHHHH		15.1925619855
1404UbiquitinationTRLADALKLQDQLKS
HHHHHHHHHHHHHCC		45.91-
1414UbiquitinationDQLKSPVKTLSEGVK
HHHCCCCCHHCHHHH		47.32-
1543PhosphorylationQASRQERYSSLMAYK
CCCHHHHHHHHHCCC		11.2341301429
1544PhosphorylationASRQERYSSLMAYKL
CCHHHHHHHHHCCCC		24.1841301435
1545PhosphorylationSRQERYSSLMAYKLP
CHHHHHHHHHCCCCC		17.1528066266
1549PhosphorylationRYSSLMAYKLPVEAV
HHHHHHCCCCCHHHH		10.0928066266
1608PhosphorylationLELEELDSSIKWKLL
CCHHHCCCCCCEEEC		46.7373244639
1609PhosphorylationELEELDSSIKWKLLP
CHHHCCCCCCEEECC		28.0521743459
1611UbiquitinationEELDSSIKWKLLPQE
HHCCCCCCEEECCCC		39.98-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABC8B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABC8B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABC8B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABC8B_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABC8B_MOUSE

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Related Literatures of Post-Translational Modification

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