EXC6B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXC6B_MOUSE
• UniProt AC: A6H5Z3
• Protein Name: Exocyst complex component 6B
• Gene Name: Exoc6b
• Organism: Mus musculus (Mouse).
• Sequence Length: 810
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MERAKMAEESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIVLQQPRIGSKRKSKKDVYTIFDAEVESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLDNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	EHGRFMEKLETRIRN CCHHHHHHHHHHHHH	39.57	-
241	Phosphorylation	LQQPRIGSKRKSKKD HCCCCCCCCCCCCCC	27.24	22324799
259	Phosphorylation	IFDAEVESTSPKSEQ EEEEEECCCCCCCCC	39.08	25293948
260	Phosphorylation	FDAEVESTSPKSEQD EEEEECCCCCCCCCC	35.23	25293948
261	Phosphorylation	DAEVESTSPKSEQDS EEEECCCCCCCCCCC	39.34	25521595
264	Phosphorylation	VESTSPKSEQDSGIL ECCCCCCCCCCCCCC	43.82	25338131
268	Phosphorylation	SPKSEQDSGILDVED CCCCCCCCCCCCCCC	27.68	25338131
454	Phosphorylation	ILDSDNYSPIPVTSE HHCCCCCCCCCCCCH	23.70	25338131
517	Phosphorylation	FSEDLHLSSTEVDDM CCCCCCCCCHHHHHH	25.19	25338131
518	Phosphorylation	SEDLHLSSTEVDDMI CCCCCCCCHHHHHHH	34.64	25338131
810	Phosphorylation	GLISSHHS------- HHHHCCCC-------	36.17	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXC6B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXC6B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXC6B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXC6B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.