RABE1_MOUSE - dbPTM
RABE1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RABE1_MOUSE
UniProt AC O35551
Protein Name Rab GTPase-binding effector protein 1
Gene Name Rabep1
Organism Mus musculus (Mouse).
Sequence Length 862
Subcellular Localization Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
Protein Description Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A..
Protein Sequence MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAIMKETVRDYEHQFHLRLEQERAQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRVNKRKDNKKTDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLMLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLKQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVEVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAQPGPAPQ
------CCCCCCCCC		25.03-
76PhosphorylationDDLGHLRTQLWEAQA
HHHHHHHHHHHHHHH		34.0818779572
107AcetylationQEAIDEVKRQWREEV
HHHHHHHHHHHHHHH		36.507923381
107UbiquitinationQEAIDEVKRQWREEV
HHHHHHHHHHHHHHH		36.50-
116PhosphorylationQWREEVASLQAIMKE
HHHHHHHHHHHHHHH		26.62-
122AcetylationASLQAIMKETVRDYE
HHHHHHHHHHHCCCC		44.097923391
128PhosphorylationMKETVRDYEHQFHLR
HHHHHCCCCHHHHHH		12.5429514104
162PhosphorylationADLRRRLSEGQEEEN
HHHHHHHHHCHHHHH		37.5630635358
246PhosphorylationAVLNTQKSVLQEDAE
HHHHCCHHHHHHHHH		20.4529514104
282AcetylationQLKHTWQKANDQFLE
HHHHHHHHHHHHHHH		40.49-
359PhosphorylationLTQEESSTPLSNEEE
ECCCCCCCCCCCCHH		37.2129899451
362PhosphorylationEESSTPLSNEEEHLD
CCCCCCCCCCHHHHH		43.3229899451
370PhosphorylationNEEEHLDSTHGSVHS
CCHHHHHCCCCCEEC		28.7629899451
371PhosphorylationEEEHLDSTHGSVHSL
CHHHHHCCCCCEECC		29.8929899451
374PhosphorylationHLDSTHGSVHSLDAD
HHHCCCCCEECCCCC		14.7329899451
377PhosphorylationSTHGSVHSLDADLML
CCCCCEECCCCCEEC		26.2829899451
386PhosphorylationDADLMLPSGDPFSKS
CCCEECCCCCCCCCC		52.4429899451
393PhosphorylationSGDPFSKSDNDMFKD
CCCCCCCCCCCHHHH		40.2123375375
407PhosphorylationDGLRRAQSTDSLGTS
HHHHHHHCCCCCCCC		32.9527087446
408PhosphorylationGLRRAQSTDSLGTSS
HHHHHHCCCCCCCCH		19.9625521595
410PhosphorylationRRAQSTDSLGTSSSL
HHHHCCCCCCCCHHH		28.8727087446
413PhosphorylationQSTDSLGTSSSLQSK
HCCCCCCCCHHHHHH		30.6325521595
414PhosphorylationSTDSLGTSSSLQSKA
CCCCCCCCHHHHHHH		19.0127742792
415PhosphorylationTDSLGTSSSLQSKAL
CCCCCCCHHHHHHHH		34.6025521595
416PhosphorylationDSLGTSSSLQSKALG
CCCCCCHHHHHHHHC		30.1425168779
419PhosphorylationGTSSSLQSKALGYNY
CCCHHHHHHHHCCCC		25.7825619855
430PhosphorylationGYNYKAKSAGNLDES
CCCCCCCCCCCCCHH		46.3926643407
437PhosphorylationSAGNLDESDFGPLVG
CCCCCCHHHCCCCCC		37.6026643407
447PhosphorylationGPLVGADSVSENFDT
CCCCCCCCCCCCCCE		27.3226643407
456PhosphorylationSENFDTVSLGSLQMP
CCCCCEEEECCEECC		29.1623649490
459PhosphorylationFDTVSLGSLQMPSGF
CCEEEECCEECCCCE		22.2629899451
480PhosphorylationERAIKAMTPEQEETA
HHHHHHCCHHHHHHH		28.6527180971
488PhosphorylationPEQEETASLLSSVTQ
HHHHHHHHHHHHHHH		36.9430352176
651PhosphorylationRLQKDNDSLQGKHSL
HHHCCCCCCCCCCCE		28.9330635358
744 (in isoform 6)Phosphorylation-4.9425338131
745 (in isoform 6)Phosphorylation-41.5925338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RABE1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RABE1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RABE1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KCTD7_HUMANKCTD7physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RABE1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, AND MASSSPECTROMETRY.

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