KCTD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCTD7_HUMAN
• UniProt AC: Q96MP8
• Protein Name: BTB/POZ domain-containing protein KCTD7
• Gene Name: KCTD7
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Subcellular Localization: Cell membrane. Cytoplasm, cytosol.
• Protein Description: May be involved in the control of excitability of cortical neurons..
• Protein Sequence: MVVVTGREPDSRRQDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGDLPPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITWW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVVVTGREPDSR ---CEEEECCCCCCC	20.93	21406692
11	Phosphorylation	VTGREPDSRRQDGAM EECCCCCCCCCCCCC	39.83	21406692
19	Phosphorylation	RRQDGAMSSSDAEDD CCCCCCCCCCHHCCC	26.59	25921289
20	Phosphorylation	RQDGAMSSSDAEDDF CCCCCCCCCHHCCCC	21.10	25921289
67	Phosphorylation	AHFTTRLSTLRCYED CEECCCHHHCCCCHH	23.31	23532336
131	Phosphorylation	AVYKEAQYYAIGPLL HHHHHHHHHHHHHHH	11.25	22817900
162	Phosphorylation	AFLGLMPYYKDHLER HHHHCHHHHHHHHHH	14.80	22817900
163	Phosphorylation	FLGLMPYYKDHLERI HHHCHHHHHHHHHHH	12.22	22817900
200	Phosphorylation	FKEEMPITPYECPLL EECCCCCCCCCCCCC	17.59	27273156
202	Phosphorylation	EEMPITPYECPLLNS CCCCCCCCCCCCCCC	22.86	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCTD7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCTD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCTD7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCTD7_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00810: Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (
• OMIM Disease
• 611726: Epilepsy, progressive myoclonic 3, with or without intracellular inclusions (EPM3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-162 AND TYR-163, ANDMASS SPECTROMETRY.
PubMed: 18083107