UTP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTP4_MOUSE
• UniProt AC: Q8R2N2
• Protein Name: U3 small nucleolar RNA-associated protein 4 homolog
• Gene Name: Utp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 686
• Subcellular Localization: Nucleus, nucleolus . Chromosome . Found predominantly at the fibrillar center.
• Protein Description: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1..
• Protein Sequence: MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRGTEALCWAGGQRLFSAGLNGEILEYDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPEKIQFARNFDRQKSRILSLCWHPAGTHVAAGSLDYISVFDVKSGSIIRKMVLDRQHLGVTKSRCIVWGVAFLSDGTVISVDSVGKVQLWDSATGTLVKSHLVANADVQSIAVADQEDSFVVGTAEGTVFHFQLVSMTSNSSEKQWVRTKPFQHHTHDVRAVAHSPTALISGGTDTHLVIRPLMERVEVKNYDAALRKITFPHRRLISCSKRRQLLLFQFAHHLELWRLGSTSATGKNGDTLPLSKNADHLLHLKTKGPENIICSCVSPCGSWIAYSTASRFFLYRLKYERDNISLQRVSKLPSFLRSALHILFSEDSTKLLVASNQGSLHIVHLSEGSFKHLHTFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPEKQYTEWSRSLQKQGFHQLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNEKTVLYNPLPPKNESDVFLRRTTHGFKMSKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	QALNIKYTLDAFGGP HHHCCEEEEECCCCC		28576409
225	Phosphorylation	VQLWDSATGTLVKSH EEEEECCCCCEEEEE		28059163
227	Phosphorylation	LWDSATGTLVKSHLV EEECCCCCEEEEEEE		28059163
321	Ubiquitination	LMERVEVKNYDAALR HHHEEEECCHHHHHH		-
323	Phosphorylation	ERVEVKNYDAALRKI HEEEECCHHHHHHHC		29514104
432	Ubiquitination	ISLQRVSKLPSFLRS CCHHHHHCCHHHHHH		27667366
569	Ubiquitination	EWSRSLQKQGFHQLW HHHHHHHHCCCHHEE		-
637	Phosphorylation	SDVFLRRTTHGFKMS CCCEEEECCCCCCHH		24719451
642	Ubiquitination	RRTTHGFKMSKIYKP EECCCCCCHHHCCCC		-
645	Ubiquitination	THGFKMSKIYKPLLF CCCCCHHHCCCCCCH		-
648	Ubiquitination	FKMSKIYKPLLFMDL CCHHHCCCCCCHHHH		-
680	Ubiquitination	AQLPPPIKKKKFGT- HHCCCCCCCCCCCC-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTP4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTP4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UTP4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.