RS19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS19_MOUSE
• UniProt AC: Q9CZX8
• Protein Name: 40S ribosomal protein S19
• Gene Name: Rps19
• Organism: Mus musculus (Mouse).
• Sequence Length: 145
• Protein Description: Required for pre-rRNA processing and maturation of 40S ribosomal subunits..
• Protein Sequence: MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVRPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MPGVTVKDVNQQEF -CCCCCCCCCCHHHH	46.74	55170029
23	Acetylation	RALAAFLKKSGKLKV HHHHHHHHHHCCCCC	38.14	23864654
23	Succinylation	RALAAFLKKSGKLKV HHHHHHHHHHCCCCC	38.14	23954790
23	Malonylation	RALAAFLKKSGKLKV HHHHHHHHHHCCCCC	38.14	26320211
29	Ubiquitination	LKKSGKLKVPEWVDT HHHHCCCCCCHHHHH	60.26	27667366
29	Acetylation	LKKSGKLKVPEWVDT HHHHCCCCCCHHHHH	60.26	22826441
29	Malonylation	LKKSGKLKVPEWVDT HHHHCCCCCCHHHHH	60.26	26320211
38	Acetylation	PEWVDTVKLAKHKEL CHHHHHHHHHHCCCC	44.83	22826441
43	Acetylation	TVKLAKHKELAPYDE HHHHHHCCCCCCCCC	54.43	22826441
48	Phosphorylation	KHKELAPYDENWFYT HCCCCCCCCCCCCHH	30.22	-
59	Phosphorylation	WFYTRAASTARHLYL CCHHHHHHHCCHHHH	22.93	19200342
67	Methylation	TARHLYLRGGAGVGS HCCHHHHCCCCCCCC	28.13	29232949
74	Phosphorylation	RGGAGVGSMTKIYGG CCCCCCCCCEEEECC	22.37	30635358
76	Phosphorylation	GAGVGSMTKIYGGRQ CCCCCCCEEEECCCC	18.91	30635358
77	Acetylation	AGVGSMTKIYGGRQR CCCCCCEEEECCCCC	25.86	23806337
77	Succinylation	AGVGSMTKIYGGRQR CCCCCCEEEECCCCC	25.86	23806337
93	Phosphorylation	GVRPSHFSRGSKSVA CCCHHHCCCCCHHHH	30.24	29514104
111	Malonylation	LQALEGLKMVEKDQD HHHHHHHCCEEECCC	52.32	26320211
111	Ubiquitination	LQALEGLKMVEKDQD HHHHHHHCCEEECCC	52.32	27667366
111	Acetylation	LQALEGLKMVEKDQD HHHHHHHCCEEECCC	52.32	22733758
115	Acetylation	EGLKMVEKDQDGGRK HHHCCEEECCCCCCE	49.64	23806337
122	Ubiquitination	KDQDGGRKLTPQGQR ECCCCCCEECCCCHH	61.05	27667366
143	Ubiquitination	GQVAAANKKH----- HHHHHHHCCC-----	47.71	27667366
143	Succinylation	GQVAAANKKH----- HHHHHHHCCC-----	47.71	23806337
143	Malonylation	GQVAAANKKH----- HHHHHHHCCC-----	47.71	26320211
143	Succinylation	GQVAAANKKH----- HHHHHHHCCC-----	47.71	-
143	Acetylation	GQVAAANKKH----- HHHHHHHCCC-----	47.71	23806337
144	Malonylation	QVAAANKKH------ HHHHHHCCC------	55.12	25418362

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
59	S	Phosphorylation	Kinase	CAMK1	Q14012	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RS19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS19_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AROS_MOUSE	Rps19bp1	physical	16289379

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.