AROS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AROS_MOUSE
• UniProt AC: Q8C6B9
• Protein Name: Active regulator of SIRT1
• Gene Name: Rps19bp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 143
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity)..
• Protein Sequence: MSAALVRRGLELLAASEAPRAVPGQVQASGTPAKRTRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPESVTQQILQQNQGRKACDRLVAKTKNKKKKKKKAEGTVFTEEDFQKFQREYFGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Citrullination	-MSAALVRRGLELLA -CCHHHHHHHHHHHH	28.00	-
7	Citrullination	-MSAALVRRGLELLA -CCHHHHHHHHHHHH	28.00	24463520
29	Phosphorylation	VPGQVQASGTPAKRT CCCCCCCCCCCCHHH	26.55	25159016
31	Phosphorylation	GQVQASGTPAKRTRR CCCCCCCCCCHHHHH	19.99	26824392
85	Methylation	LKFMTSMRSTVPESV HHHHHHHHCCCCHHH	29.01	16188307
86	Phosphorylation	KFMTSMRSTVPESVT HHHHHHHCCCCHHHH	25.72	-
103	Methylation	ILQQNQGRKACDRLV HHHHCHHHHHHHHHH	17.40	16188315
143	Phosphorylation	FQREYFGS------- HHHHHHCC-------	27.44	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AROS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AROS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AROS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AROS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.