PSMD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD3_MOUSE
• UniProt AC: P14685
• Protein Name: 26S proteasome non-ATPase regulatory subunit 3
• Gene Name: Psmd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 530
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MKQEGSARRRGADKAKPPPGGEQEPPPPAPQDVEMKEEAAAGSGSTGEGDGKAAATEHSQRELDTVTLEDIKEHVRQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVHGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASAPLLPEVEAYLQLLMVIFLMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQTDGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKQEGSARRRGAD --CCCCCCCCCCCCC	20.18	25266776
36	Ubiquitination	APQDVEMKEEAAAGS CCCCCCCHHHHHCCC	38.61	22790023
43	Phosphorylation	KEEAAAGSGSTGEGD HHHHHCCCCCCCCCC	25.50	27087446
45	Phosphorylation	EAAAGSGSTGEGDGK HHHCCCCCCCCCCCC	34.63	25521595
46	Phosphorylation	AAAGSGSTGEGDGKA HHCCCCCCCCCCCCC	42.66	27087446
52	Ubiquitination	STGEGDGKAAATEHS CCCCCCCCCHHCHHH	39.32	22790023
72	Acetylation	TVTLEDIKEHVRQLE CCCHHHHHHHHHHHH	54.83	23954790
72	Succinylation	TVTLEDIKEHVRQLE CCCHHHHHHHHHHHH	54.83	23954790
72	Ubiquitination	TVTLEDIKEHVRQLE CCCHHHHHHHHHHHH	54.83	-
80	Ubiquitination	EHVRQLEKAVSGKEP HHHHHHHHHHCCCCC	63.78	27667366
80	Malonylation	EHVRQLEKAVSGKEP HHHHHHHHHHCCCCC	63.78	26320211
83	Phosphorylation	RQLEKAVSGKEPRFV HHHHHHHCCCCCHHH	49.35	18779572
205	Ubiquitination	ALDLVAAKCYYYHAR HHHHHHHHHHHHHHH	17.03	22790023
205	Acetylation	ALDLVAAKCYYYHAR HHHHHHHHHHHHHHH	17.03	22826441
207	Phosphorylation	DLVAAKCYYYHARVY HHHHHHHHHHHHHHH	13.32	23140645
208	Phosphorylation	LVAAKCYYYHARVYE HHHHHHHHHHHHHHH	9.76	23140645
219	Ubiquitination	RVYEFLDKLDVVRSF HHHHHHHHHHHHHHH	49.05	22790023
219	Acetylation	RVYEFLDKLDVVRSF HHHHHHHHHHHHHHH	49.05	22826441
265	Ubiquitination	SLYDQAEKLVSKSVF HHHHHHHHHHHCCCC	58.15	22790023
269	Ubiquitination	QAEKLVSKSVFPEQA HHHHHHHCCCCHHHC	43.06	22790023
292	Ubiquitination	LYYTGRIKAIQLEYS HHHHCCCEEEEEHHH	37.77	27667366
298	Phosphorylation	IKAIQLEYSEARRTM CEEEEEHHHHHHHHH	22.02	28066266
299	Phosphorylation	KAIQLEYSEARRTMT EEEEEHHHHHHHHHH	18.53	28066266
321	Ubiquitination	QHTAVGFKQTVHKLL CCCCCCHHHHHHHHH	38.85	22790023
348	Phosphorylation	RLQFRQPSLKRSLMP HHHCCCHHHHHHHHH	37.88	19854140
370	Acetylation	VRTGNLAKFNQVLDQ HHHCCHHHHHHHHHH	48.27	22826441
407	Phosphorylation	KTGVRMISLSYSRIS HHCCEEEEECCCCCC	11.26	29899451
409	Phosphorylation	GVRMISLSYSRISLA CCEEEEECCCCCCHH	17.80	29472430
410	Phosphorylation	VRMISLSYSRISLAD CEEEEECCCCCCHHH	13.78	29472430
411	Phosphorylation	RMISLSYSRISLADI EEEEECCCCCCHHHH	21.55	29472430
414	Phosphorylation	SLSYSRISLADIAQK EECCCCCCHHHHHHH	19.18	-
421	Ubiquitination	SLADIAQKLQLDSPE CHHHHHHHHCCCCHH	29.22	-
426	Phosphorylation	AQKLQLDSPEDAEFI HHHHCCCCHHHHHHH	38.49	21743459
436	Ubiquitination	DAEFIVAKAIRDGVI HHHHHHHHHHHCCCE	33.19	22790023
446	Phosphorylation	RDGVIEASINHEKGY HCCCEEEEECCCCCC	15.90	25338131
451	Malonylation	EASINHEKGYVQSKE EEEECCCCCCCCCHH	48.25	26320211
457	Ubiquitination	EKGYVQSKEMIDIYS CCCCCCCHHHEEECC	33.92	22790023
477	Phosphorylation	LAFHQRISFCLDIHN HHHHHHHHHHHHHCC	16.46	-
495	Ubiquitination	KAMRFPPKSYNKDLE EEECCCCCCCCCCHH	66.85	27667366
496	Phosphorylation	AMRFPPKSYNKDLES EECCCCCCCCCCHHH	39.45	23737553
497	Phosphorylation	MRFPPKSYNKDLESA ECCCCCCCCCCHHHH	32.15	23737553
499	Acetylation	FPPKSYNKDLESAEE CCCCCCCCCHHHHHH	56.29	23954790
499	Ubiquitination	FPPKSYNKDLESAEE CCCCCCCCCHHHHHH	56.29	22790023
503	Phosphorylation	SYNKDLESAEERRER CCCCCHHHHHHHHHH	48.56	26824392
528	Phosphorylation	MAEDDDDSFP----- HHHCCCCCCC-----	46.54	19854140

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.