PRS8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS8_MOUSE
• UniProt AC: P62196
• Protein Name: 26S proteasome regulatory subunit 8
• Gene Name: Psmc5
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALDGPEQM ------CCCCCHHHC	17.85	16857966
23	Phosphorylation	AGSGLRQYYLSKIEE CCCCHHHHHHHHHHH	10.43	28576409
24	Phosphorylation	GSGLRQYYLSKIEEL CCCHHHHHHHHHHHH	9.00	28576409
38	Ubiquitination	LQLIVNDKSQNLRRL HHHHHCCCCHHHHHH	49.06	-
88	Malonylation	DKKKVLVKVHPEGKF CCCCEEEEEECCCCE	30.57	26320211
88	Ubiquitination	DKKKVLVKVHPEGKF CCCCEEEEEECCCCE	30.57	-
94	Acetylation	VKVHPEGKFVVDVDK EEEECCCCEEEEECC	33.07	23236377
101	Ubiquitination	KFVVDVDKNIDINDV CEEEEECCCCCCCCC	56.50	-
120	Phosphorylation	RVALRNDSYTLHKIL EEEECCCCEEHHHHC	24.46	22817900
122	Phosphorylation	ALRNDSYTLHKILPN EECCCCEEHHHHCCC	26.74	27681418
125	Ubiquitination	NDSYTLHKILPNKVD CCCEEHHHHCCCCCC	49.39	-
148	Phosphorylation	EKVPDSTYEMIGGLD EECCCCHHHHCCCHH	13.88	28576409
170	Ubiquitination	EVIELPVKHPELFEA HHHCCCCCCHHHHHH	52.05	-
189	Phosphorylation	QPKGVLLYGPPGTGK CCCEEEEECCCCCCH	24.35	22817900
196	Ubiquitination	YGPPGTGKTLLARAV ECCCCCCHHHHHHHH	35.52	-
209	Glutathionylation	AVAHHTDCTFIRVSG HHHHCCCCEEEECCH	3.35	24333276
222	Acetylation	SGSELVQKFIGEGAR CHHHHHHHHHHHHHH	31.31	23236377
222	Ubiquitination	SGSELVQKFIGEGAR CHHHHHHHHHHHHHH	31.31	27667366
263	Phosphorylation	SSRLEGGSGGDSEVQ CCCCCCCCCCCHHHH	50.92	27841257
267	Phosphorylation	EGGSGGDSEVQRTML CCCCCCCHHHHHHHH	42.83	22324799
272	O-linked_Glycosylation	GDSEVQRTMLELLNQ CCHHHHHHHHHHHHH	14.71	55413595
287	Ubiquitination	LDGFEATKNIKVIMA CCCHHHCCCCEEEEE	64.82	-
330	Ubiquitination	EARLDILKIHSRKMN HHHHHHHHHHHHCCC	38.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP19_MOUSE	Prpf19	physical	17349974
HOME3_MOUSE	Homer3	physical	22486777
CALR_MOUSE	Calr	physical	22486777
GRM1_MOUSE	Grm1	physical	22486777
PHLP_RAT	Pdcl	physical	9551090

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.