PASK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PASK_MOUSE
• UniProt AC: Q8CEE6
• Protein Name: PAS domain-containing serine/threonine-protein kinase
• Gene Name: Pask
• Organism: Mus musculus (Mouse).
• Sequence Length: 1383
• Subcellular Localization: Cytoplasm. Nucleus. Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails..
• Protein Description: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation..
• Protein Sequence: MEDRGPPVFAEDWKCLSESPPVQEGPAAQATFEPSKPLSIAHKHLSRKNGLSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCSGSLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRIGEKIPVSVWIKRLQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLLPDGTIYGVNHSFALMLFGYGKTELLGKNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGEMNSDAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQVSSRTQTRLETGYKILPSSACQPSLGVDSNPEDGEQSLLTDQQSIPKRNLPAHGGQNQLDTSEISLPVLKEHLLSEIQKNISEESPLTHRKWLSKVQQNPTKGSLPIHEEQLLFAGQHIHVLGKEDPSAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVDTCNLHQEAQLELMGVSSPNPWADATMPEPHTTGQIAGGSLTYCPQYRSEWASQQRGQDSAPSPSGMACVLLGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDLGGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHCSCTTSELSEAPSLSVVGSDLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPDPGPNDMCLSAEKPRPSAQITSTPVARGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQGSATLFCCWLVKDLFHSHRDSATRTRLFLASLPSSTHSMPELSGSSFGEVLRAKPWFEESPTPAELEGLAACEGEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQPESGLLSAASLEIGSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDRGPPV -------CCCCCCCC	49.22	-
17	Phosphorylation	AEDWKCLSESPPVQE CCCCCCCCCCCCCCC	45.56	26745281
19	Phosphorylation	DWKCLSESPPVQEGP CCCCCCCCCCCCCCC	31.00	22942356
31	Phosphorylation	EGPAAQATFEPSKPL CCCCCEECCCCCCCC	19.22	22817900
39	Phosphorylation	FEPSKPLSIAHKHLS CCCCCCCHHHHHHHH	26.68	19060867
102	Phosphorylation	PTAGPLGSTSCCSLL CCCCCCCHHHHHHHH	25.49	19060867
103	Phosphorylation	TAGPLGSTSCCSLLR CCCCCCHHHHHHHHH	24.80	25293948
104	Phosphorylation	AGPLGSTSCCSLLRG CCCCCHHHHHHHHHH	18.15	22817900
107	Phosphorylation	LGSTSCCSLLRGLAS CCHHHHHHHHHHHHC	34.46	21183079
114	Phosphorylation	SLLRGLASGCSGSLL HHHHHHHCCCCCEEC	45.43	25293948
117	Phosphorylation	RGLASGCSGSLLSTP HHHHCCCCCEECCCC	34.64	25293948
119	Phosphorylation	LASGCSGSLLSTPVC HHCCCCCEECCCCCC	15.16	25293948
122	Phosphorylation	GCSGSLLSTPVCNPN CCCCEECCCCCCCCC	35.64	25293948
140	Phosphorylation	FTVDAKTTEILVAND EEEECCCCEEEEECH	21.96	22942356
305	Phosphorylation	VGRARDGTTFPLSLK CCCCCCCCEEEEEEE	29.56	29514104
448	Phosphorylation	LARDHMPSQDETLKL EEECCCCCCCCCEEE	42.56	29233185
452	Phosphorylation	HMPSQDETLKLVGGQ CCCCCCCCEEECCCC	37.17	29233185
461	Phosphorylation	KLVGGQVSSRTQTRL EECCCCCCCCCCCCC	13.25	26643407
462	Phosphorylation	LVGGQVSSRTQTRLE ECCCCCCCCCCCCCC	40.25	26643407
464	Phosphorylation	GGQVSSRTQTRLETG CCCCCCCCCCCCCCC	35.92	26643407
466	Phosphorylation	QVSSRTQTRLETGYK CCCCCCCCCCCCCCE	36.29	26643407
483	Phosphorylation	PSSACQPSLGVDSNP CCCCCCCCCCCCCCC	16.33	25293948
488	Phosphorylation	QPSLGVDSNPEDGEQ CCCCCCCCCCCCCCC	52.45	25293948
521	Phosphorylation	GQNQLDTSEISLPVL CCCCCCCCCCCHHHH	32.38	26370283
541	Phosphorylation	SEIQKNISEESPLTH HHHHHCCCCCCCCHH	44.71	28066266
544	Phosphorylation	QKNISEESPLTHRKW HHCCCCCCCCHHHHH	22.58	27600695
547	Phosphorylation	ISEESPLTHRKWLSK CCCCCCCHHHHHHHH	24.02	28066266
612	Phosphorylation	VDAKLFASCEDSEPL CCHHHEECCCCCCCC	15.65	29514104
689	Phosphorylation	SQQRGQDSAPSPSGM HHHCCCCCCCCCCCC	33.90	25293948
692	Phosphorylation	RGQDSAPSPSGMACV CCCCCCCCCCCCEEE	31.26	25293948
694	Phosphorylation	QDSAPSPSGMACVLL CCCCCCCCCCEEEEC	45.60	25293948
703	Phosphorylation	MACVLLGTPTLDEPW CEEEECCCCCCCCCC	17.05	25293948
705	Phosphorylation	CVLLGTPTLDEPWPG EEECCCCCCCCCCCC	46.83	25293948
732	Phosphorylation	IKEQLSKSSCEGNLG HHHHHCCCCCCCCCC	36.52	28066266
733	Phosphorylation	KEQLSKSSCEGNLGI HHHHCCCCCCCCCCC	21.66	28066266
818	Phosphorylation	LKDQTDRTPSHCSCT HCCCCCCCCCCCCCC	31.77	25293948
820	Phosphorylation	DQTDRTPSHCSCTTS CCCCCCCCCCCCCHH	36.19	25293948
823	Phosphorylation	DRTPSHCSCTTSELS CCCCCCCCCCHHHHC	14.74	25293948
825	Phosphorylation	TPSHCSCTTSELSEA CCCCCCCCHHHHCCC	19.64	25293948
826	Phosphorylation	PSHCSCTTSELSEAP CCCCCCCHHHHCCCC	25.24	25293948
827	Phosphorylation	SHCSCTTSELSEAPS CCCCCCHHHHCCCCC	20.56	25293948
830	Phosphorylation	SCTTSELSEAPSLSV CCCHHHHCCCCCEEE	27.88	25293948
834	Phosphorylation	SELSEAPSLSVVGSD HHHCCCCCEEEECCC	40.08	25293948
836	Phosphorylation	LSEAPSLSVVGSDLD HCCCCCEEEECCCCC	21.06	25293948
840	Phosphorylation	PSLSVVGSDLDVGIL CCEEEECCCCCCCCC	24.32	25293948
851	Phosphorylation	VGILHRQTSDILVDR CCCCCCCCCCEEECH	28.46	28066266
852	Phosphorylation	GILHRQTSDILVDRE CCCCCCCCCEEECHH	17.83	27600695
871	Phosphorylation	TGTYFDLSEGQRFQE HCEEEECCCCHHHHH	41.34	-
936	Phosphorylation	RPSAQITSTPVARGA CCCCCCCCCCCCCCC	32.13	28066266
937	Phosphorylation	PSAQITSTPVARGAT CCCCCCCCCCCCCCC	17.09	28066266
944	Phosphorylation	TPVARGATSLQQEIQ CCCCCCCCCHHHHHH	32.56	25338131
945	Phosphorylation	PVARGATSLQQEIQE CCCCCCCCHHHHHHH	24.52	26370283
996	Phosphorylation	LVKDLFHSHRDSATR HHHHHHHHCCCCHHH	16.94	28066266
1000	Phosphorylation	LFHSHRDSATRTRLF HHHHCCCCHHHHHHH	31.34	25266776
1002	Phosphorylation	HSHRDSATRTRLFLA HHCCCCHHHHHHHHH	36.20	28066266
1010	Phosphorylation	RTRLFLASLPSSTHS HHHHHHHHCCCCCCC	42.85	25293948
1013	Phosphorylation	LFLASLPSSTHSMPE HHHHHCCCCCCCCCC	53.84	25293948
1014	Phosphorylation	FLASLPSSTHSMPEL HHHHCCCCCCCCCCC	28.35	25293948
1015	Phosphorylation	LASLPSSTHSMPELS HHHCCCCCCCCCCCC	23.47	25293948
1017	Phosphorylation	SLPSSTHSMPELSGS HCCCCCCCCCCCCCC	35.80	25293948
1022	Phosphorylation	THSMPELSGSSFGEV CCCCCCCCCCCHHHH	34.66	25293948
1024	Phosphorylation	SMPELSGSSFGEVLR CCCCCCCCCHHHHHH	21.08	25293948
1025	Phosphorylation	MPELSGSSFGEVLRA CCCCCCCCHHHHHHC	40.57	25293948
1039	Phosphorylation	AKPWFEESPTPAELE CCCCCCCCCCHHHHH	27.20	25293948
1041	Phosphorylation	PWFEESPTPAELEGL CCCCCCCCHHHHHHH	44.39	25293948
1221	Phosphorylation	ERGKLFYTFCGTIEY HCCCEEEEECCCHHH	12.71	-
1225	Phosphorylation	LFYTFCGTIEYCAPE EEEEECCCHHHHCCC	16.30	-
1337	Phosphorylation	QPESGLLSAASLEIG CCCCCCCCHHHHCCC	27.17	25266776
1340	Phosphorylation	SGLLSAASLEIGSRS CCCCCHHHHCCCCCC	26.67	26643407
1345	Phosphorylation	AASLEIGSRSPSEMA HHHHCCCCCCHHHHH	34.93	26643407
1347	Phosphorylation	SLEIGSRSPSEMAQR HHCCCCCCHHHHHHH	34.18	26643407
1349	Phosphorylation	EIGSRSPSEMAQREG CCCCCCHHHHHHHHC	41.05	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PASK_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1221	T	Phosphorylation	Autophosphorylated on Thr-1221 and Thr-1225.	-
1225	T	Phosphorylation	Autophosphorylated on Thr-1221 and Thr-1225.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PASK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PASK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.