WDR35_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR35_MOUSE
• UniProt AC: Q8BND3
• Protein Name: WD repeat-containing protein 35
• Gene Name: Wdr35
• Organism: Mus musculus (Mouse).
• Sequence Length: 1181
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body . Immunofluorescence studies in IMCD3 cells show that Wdr35 accumulates at and around centrosome
• Protein Description: May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis..
• Protein Sequence: MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	IAVPNNVKLKCISWN EECCCCCEEEEEEEC	44.33	27667366
152	Ubiquitination	DGNRIWGKDLKGIQL CCCEECCCCCCCCEE	44.91	-
487	Phosphorylation	YHVDDVPSGSVDGVF EECCCCCCCCCCCCC	43.48	25293948
489	Phosphorylation	VDDVPSGSVDGVFDY CCCCCCCCCCCCCCH	22.75	25293948
529	Phosphorylation	ESGVIQRYSFPNVAL CCCCEEECCCCCCEE	9.78	21659604
530	Phosphorylation	SGVIQRYSFPNVALI CCCEEECCCCCCEEE	36.09	21659604
577	Phosphorylation	FDLDTRVTDSTGQQV EECCCCCCCCCCCHH	22.42	25293948
579	Phosphorylation	LDTRVTDSTGQQVVG CCCCCCCCCCCHHHH	25.68	25293948
580	Phosphorylation	DTRVTDSTGQQVVGE CCCCCCCCCCHHHHH	41.65	25293948
815	Ubiquitination	EYFADRQKWQNAVQY HHHHHHHHHHHHHHH	52.20	-
877	Phosphorylation	GMCEQAVSAFLKCNQ CCHHHHHHHHHHCCC	19.13	-
963	Acetylation	EEAKKRTKPLRVKKL HHHHHCCCCCHHHHH	46.19	2383467
998	Phosphorylation	GKVKGKNSEATSALA CCCCCCCHHHHHHHH	31.90	25338131
1014	Phosphorylation	LLEEEVLSTTSRFTD HHHHHHHHCCCCCCC	34.51	25338131
1015	Phosphorylation	LEEEVLSTTSRFTDN HHHHHHHCCCCCCCC	25.32	25338131
1090	Acetylation	TCSKAFIKLESLETL CCCHHHHCHHHHHHC	39.48	7719079
1124	Phosphorylation	TPKDNRKSELNSLLE CCCCCCHHHHHHHHC	44.04	25338131
1150	Phosphorylation	TGSPIIEYQFWVCKV CCCCEEEEEHHHHHH	9.90	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR35_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR35_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR35_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR35_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.