MAGE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGE1_MOUSE
• UniProt AC: Q6PCZ4
• Protein Name: Melanoma-associated antigen E1
• Gene Name: Magee1
• Organism: Mus musculus (Mouse).
• Sequence Length: 918
• Subcellular Localization: Cytoplasm, perinuclear region . Nucleus . Cell membrane . In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colo
• Protein Description: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity)..
• Protein Sequence: MSLVSQNSRRRRGGRANARRNNGKGHPAAVPGPDVPRDRNDPKILQGLRASEGPGTSMLPTPREGPSASVPPTASEGSSAPRQFIISQGPNTSEMPTSRKGRGASRPPAVSAGLNTAMSITASEGPNSPVPPTAPKGSKAYEHLPVSEGLAISEQRHSDGGPNMEPTLGEGPGISVPPTFSEESGISDEGLSIFMSPNISEGPGINEPYSVSEDPSTSVPPTDSNGLGINLPPTFGEGLSISMLFSALEEPDIFAPPPSAEGLFASMSPPSGEIQSSWVSPIIMEGCNVNVPPTSKKGLRTSVPSAACESPSTSAEGLSSSLSSISAEGFCSSLAPCAAEGSCELLPCGEGRSTSELHCLGEGSSTSQMSLAAEGPSASGMPTEANNPEEALSCCASERRNKSTSRALQKAKDPSVRPKREDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELLQFLLLKDQTKYPIKESDMREFIDKDYRHQFPEILRRAAVHLECIFRFELKELDTEEHIYILLNKLGPVPFEGLEDVPNGPKMGLLMMILGHILLNGNQAREADIWEMLWRFGVQRERRLSVFGNVKRLLSVEFVWQRYLDYRPLTDCVPVEYEFYWGPRSRAETTKMKILKFMAKIYNKDPMDWPALYNEALEEDADRVVVNNFRVARPFRRPLFAEVAPELDASGSKYSPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEDTEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQNGRKHVITCRYLSQRYLDSLRVPDSDPVQYDFVWGPRARLETSKMKALRYVARIHRKEPEDWPEQYREAMEDEANRAEAGRRPLIVRNLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLVSQNSR ------CCCCCHHHH	37.16	22324799
5	Phosphorylation	---MSLVSQNSRRRR ---CCCCCHHHHHCC	29.01	30635358
8	Phosphorylation	MSLVSQNSRRRRGGR CCCCCHHHHHCCCCC	21.37	26824392
92	Phosphorylation	IISQGPNTSEMPTSR EEECCCCCCCCCCCC	29.24	-
93	Phosphorylation	ISQGPNTSEMPTSRK EECCCCCCCCCCCCC	38.24	-
97	Phosphorylation	PNTSEMPTSRKGRGA CCCCCCCCCCCCCCC	39.59	-
98	Phosphorylation	NTSEMPTSRKGRGAS CCCCCCCCCCCCCCC	26.56	-
128	Phosphorylation	TASEGPNSPVPPTAP CCCCCCCCCCCCCCC	30.33	29514104
141	Phosphorylation	APKGSKAYEHLPVSE CCCCCCCCCCCCCCC	13.97	29514104
364	Phosphorylation	LHCLGEGSSTSQMSL EEEECCCCCCCCCCC	26.58	-
365	Phosphorylation	HCLGEGSSTSQMSLA EEECCCCCCCCCCCC	42.82	-
366	Phosphorylation	CLGEGSSTSQMSLAA EECCCCCCCCCCCCC	25.36	-
447	Phosphorylation	TIMGLGTSRVALTLK EEEEECCCEEEEEEC	23.98	28059163
593	Ubiquitination	LSVFGNVKRLLSVEF HHHCCCHHHHHCCEE	41.13	27667366
644	Phosphorylation	LKFMAKIYNKDPMDW HHHHHHHHCCCCCCH	18.56	-
700	Phosphorylation	GSKYSPHSWPESRLE CCCCCCCCCCHHHHH	47.94	29514104
730	Ubiquitination	TKLPIPKKGILYYIG CCCCCCCCCEEEEEC	45.92	22790023
742	Ubiquitination	YIGRECTKVFPDLLN EECHHHHHHCHHHHH	54.24	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGE1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAGE1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.