PSA4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA4_MOUSE
• UniProt AC: Q9R1P0
• Protein Name: Proteasome subunit alpha type-4
• Gene Name: Psma4
• Organism: Mus musculus (Mouse).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in the cytoplasmic bodies.
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRESGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	DSRTTIFSPEGRLYQ CCCCEEECCCCCEEE	20.42	28066266
33	Phosphorylation	EAIGHAGTCLGILAN HHHCCCHHHHHHHCC	12.82	18579562
54	Ubiquitination	AERRNIHKLLDEVFF HHHCCHHHHHHHHHH	47.12	-
54	Acetylation	AERRNIHKLLDEVFF HHHCCHHHHHHHHHH	47.12	22826441
64	Ubiquitination	DEVFFSEKIYKLNED HHHHHCHHHHHCCCC	50.57	-
74	S-nitrosylation	KLNEDMACSVAGITS HCCCCCCCHHHCCCC	2.42	21278135
74	Glutathionylation	KLNEDMACSVAGITS HCCCCCCCHHHCCCC	2.42	24333276
74	S-nitrosocysteine	KLNEDMACSVAGITS HCCCCCCCHHHCCCC	2.42	-
75	Phosphorylation	LNEDMACSVAGITSD CCCCCCCHHHCCCCC	12.88	18579562
127	Acetylation	AYTQFGGKRPFGVSL HHHHHCCCCCCCEEE	58.22	11924011
168	Phosphorylation	ATCIGNNSAAAVSML EEEECCCHHHHHHHH	24.24	29472430
173	Phosphorylation	NNSAAAVSMLKQDYK CCHHHHHHHHHCCHH	17.42	25521595
176	Malonylation	AAAVSMLKQDYKEGE HHHHHHHHCCHHHCC	32.26	26320211
176	Ubiquitination	AAAVSMLKQDYKEGE HHHHHHHHCCHHHCC	32.26	-
176	Acetylation	AAAVSMLKQDYKEGE HHHHHHHHCCHHHCC	32.26	22733758
180	Succinylation	SMLKQDYKEGEMTLK HHHHCCHHHCCCCHH	68.48	23954790
180	Acetylation	SMLKQDYKEGEMTLK HHHHCCHHHCCCCHH	68.48	22826441
199	Malonylation	LAVKVLNKTMDVSKL HHHHHHHHCCCHHHH	40.85	26320211
199	Ubiquitination	LAVKVLNKTMDVSKL HHHHHHHHCCCHHHH	40.85	27667366
199	Acetylation	LAVKVLNKTMDVSKL HHHHHHHHCCCHHHH	40.85	22826441
205	Ubiquitination	NKTMDVSKLSAEKVE HHCCCHHHHCHHHEE	46.43	-
205	Malonylation	NKTMDVSKLSAEKVE HHCCCHHHHCHHHEE	46.43	26320211
205	Acetylation	NKTMDVSKLSAEKVE HHCCCHHHHCHHHEE	46.43	22826441
210	Ubiquitination	VSKLSAEKVEIATLT HHHHCHHHEEEEEEE	44.90	-
210	Acetylation	VSKLSAEKVEIATLT HHHHCHHHEEEEEEE	44.90	22826441
217	Phosphorylation	KVEIATLTRESGKTV HEEEEEEECCCCCCH	28.21	28066266
220	Phosphorylation	IATLTRESGKTVIRV EEEEECCCCCCHHHH	42.15	26824392
222	Ubiquitination	TLTRESGKTVIRVLK EEECCCCCCHHHHHH	49.23	27667366
231	Ubiquitination	VIRVLKQKEVEQLIK HHHHHHHHHHHHHHH	63.24	27667366
231	Malonylation	VIRVLKQKEVEQLIK HHHHHHHHHHHHHHH	63.24	26320211
238	Ubiquitination	KEVEQLIKKHEEEEA HHHHHHHHHHHHHHH	57.58	27667366
238	Succinylation	KEVEQLIKKHEEEEA HHHHHHHHHHHHHHH	57.58	23954790
238	Malonylation	KEVEQLIKKHEEEEA HHHHHHHHHHHHHHH	57.58	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOS_HUMAN	FOS	physical	20498278

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.