HXK1_MOUSE - dbPTM
HXK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXK1_MOUSE
UniProt AC P17710
Protein Name Hexokinase-1
Gene Name Hk1
Organism Mus musculus (Mouse).
Sequence Length 974
Subcellular Localization Isoform HK1: Mitochondrion outer membrane
Peripheral membrane protein.
Isoform HK1-SC: Membrane. Isoform HK1-SC is an integral membrane protein.
Protein Description
Protein Sequence MGWGAPLLSRMLHGPGQAGETSPVPERQSGSENPASEDRRPLEKQCSHHLYTMGQNCQRGQAVDVEPKIRPPLTEEKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDKEGVQNAKEILTRLGVEPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLRGDPTNA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationGWGAPLLSRMLHGPG
CCCHHHHHHHHCCCC		24.2723737553
21 (in isoform 3)Ubiquitination-37.10-
24 (in isoform 3)Ubiquitination-8.45-
62 (in isoform 3)Ubiquitination-11.42-
77 (in isoform 3)Ubiquitination-50.39-
83PhosphorylationEKIDKYLYAMRLSDE
HHHHHHHHHHHCCHH		8.6819186949
118AcetylationYNPTASVKMLPTFVR
CCCCCHHCCCCEEHH		32.0223864654
118UbiquitinationYNPTASVKMLPTFVR
CCCCCHHCCCCEEHH		32.0222790023
118 (in isoform 3)Ubiquitination-32.0222790023
126PhosphorylationMLPTFVRSIPDGSEK
CCCEEHHCCCCCCCC		32.9229899451
133UbiquitinationSIPDGSEKGDFIALD
CCCCCCCCCCEEEEE		66.5322790023
133 (in isoform 3)Ubiquitination-66.5322790023
144PhosphorylationIALDLGGSSFRILRV
EEEECCCCCEEEEEE		25.2220415495
145PhosphorylationALDLGGSSFRILRVQ
EEECCCCCEEEEEEE		23.0920415495
147 (in isoform 3)Ubiquitination-29.04-
158PhosphorylationVQVNHEKSQNVSMES
EEECCCCCCCCCCCE		24.8125293948
162PhosphorylationHEKSQNVSMESEVYD
CCCCCCCCCCEEEEE		25.1225293948
165PhosphorylationSQNVSMESEVYDTPE
CCCCCCCEEEEECCC		24.5825293948
168PhosphorylationVSMESEVYDTPENIV
CCCCEEEEECCCCCC		15.2825293948
170PhosphorylationMESEVYDTPENIVHG
CCEEEEECCCCCCCC		18.1525293948
178PhosphorylationPENIVHGSGSQLFDH
CCCCCCCCHHHHHHH		22.0125293948
180PhosphorylationNIVHGSGSQLFDHVA
CCCCCCHHHHHHHHH		25.9625293948
187 (in isoform 3)Ubiquitination-9.81-
203UbiquitinationKRKIKDKKLPVGFTF
HCCCCCCCCCCCEEE		69.0622790023
203 (in isoform 3)Ubiquitination-69.0622790023
214S-nitrosocysteineGFTFSFPCRQSKIDE
CEEEEEECCCCCCCC		6.11-
214S-nitrosylationGFTFSFPCRQSKIDE
CEEEEEECCCCCCCC		6.1121278135
234PhosphorylationWTKRFKASGVEGADV
ECCCCHHCCCCCHHH		43.9225521595
243AcetylationVEGADVVKLLNKAIK
CCCHHHHHHHHHHHH		47.2923806337
243UbiquitinationVEGADVVKLLNKAIK
CCCHHHHHHHHHHHH		47.2922790023
243 (in isoform 3)Ubiquitination-47.2922790023
315 (in isoform 3)Ubiquitination-17.13-
333 (in isoform 3)Ubiquitination-12.10-
346 (in isoform 3)Ubiquitination-45.12-
371UbiquitinationLILVKMAKESLLFEG
HHHHHHHHHHHHHCC		44.3222790023
371 (in isoform 3)Ubiquitination-44.3222790023
389UbiquitinationPELLTRGKFTTSDVA
HHHHHCCCCCHHHEE		35.9322790023
389 (in isoform 3)Ubiquitination-35.9322790023
391PhosphorylationLLTRGKFTTSDVAAI
HHHCCCCCHHHEEEE		28.9529899451
392PhosphorylationLTRGKFTTSDVAAIE
HHCCCCCHHHEEEEE		26.5129899451
393PhosphorylationTRGKFTTSDVAAIET
HCCCCCHHHEEEEEC		27.3425521595
400PhosphorylationSDVAAIETDKEGVQN
HHEEEEECCHHHHHC		46.3826525534
402AcetylationVAAIETDKEGVQNAK
EEEEECCHHHHHCHH		64.8823236377
402UbiquitinationVAAIETDKEGVQNAK
EEEEECCHHHHHCHH		64.8822790023
402 (in isoform 3)Ubiquitination-64.8822790023
418 (in isoform 3)Ubiquitination-39.01-
431GlutathionylationCVSVQHVCTIVSFRS
CCCHHHEEEEEECCC		1.7024333276
451 (in isoform 3)Ubiquitination-34.52-
459PhosphorylationRLRDNKGTPRLRTTV
HHHCCCCCCCCEEEE		13.57-
474UbiquitinationGVDGSLYKMHPQYSR
CCCCCHHCCCHHHHH		35.7122790023
474 (in isoform 3)Ubiquitination-35.7122790023
488 (in isoform 3)Ubiquitination-34.81-
501PhosphorylationSDVRFLLSESGSGKG
HHHEEEEECCCCCHH		31.6820415495
503PhosphorylationVRFLLSESGSGKGAA
HEEEEECCCCCHHHH		34.5820415495
505PhosphorylationFLLSESGSGKGAAMV
EEEECCCCCHHHHHH		46.7620415495
507UbiquitinationLSESGSGKGAAMVTA
EECCCCCHHHHHHHH		47.2622790023
507 (in isoform 3)Ubiquitination-47.2622790023
510 (in isoform 3)Ubiquitination-11.14-
513PhosphorylationGKGAAMVTAVAYRLA
CHHHHHHHHHHHHHH		11.43-
517PhosphorylationAMVTAVAYRLAEQHR
HHHHHHHHHHHHHHH		10.2820415495
529PhosphorylationQHRQIEETLSHFRLS
HHHHHHHHHHHHHHC		22.2929472430
531PhosphorylationRQIEETLSHFRLSKQ
HHHHHHHHHHHHCHH		28.1829472430
536PhosphorylationTLSHFRLSKQALMEV
HHHHHHHCHHHHHHH		20.6125521595
544UbiquitinationKQALMEVKKKLRSEM
HHHHHHHHHHHHHHH		30.7722790023
544 (in isoform 3)Ubiquitination-30.7722790023
549PhosphorylationEVKKKLRSEMEMGLR
HHHHHHHHHHHHHCC		52.2919060867
561PhosphorylationGLRKETNSRATVKML
HCCCCCCCHHHHHCC		30.6129899451
566UbiquitinationTNSRATVKMLPSYVR
CCCHHHHHCCHHHHH		30.3022790023
566 (in isoform 3)Ubiquitination-30.3022790023
592PhosphorylationLALDLGGTNFRVLLV
EEEECCCCEEEEEEE		29.4129899451
608PhosphorylationIRSGKKRTVEMHNKI
ECCCCCEEEEEECEE		29.6926824392
624 (in isoform 3)Ubiquitination-52.54-
657PhosphorylationPRMPLGFTFSFPCKQ
CCCCCEEEEEEECCC		19.3026239621
659PhosphorylationMPLGFTFSFPCKQTS
CCCEEEEEEECCCCC		25.8126239621
662S-nitrosocysteineGFTFSFPCKQTSLDC
EEEEEEECCCCCCCC		4.87-
662S-nitrosylationGFTFSFPCKQTSLDC
EEEEEEECCCCCCCC		4.8721278135
669S-nitrosylationCKQTSLDCGILITWT
CCCCCCCCCEEEEEC		4.4124895380
669S-palmitoylationCKQTSLDCGILITWT
CCCCCCCCCEEEEEC		4.4128680068
680UbiquitinationITWTKGFKATDCVGH
EEECCCCCCCCCCCH		60.0722790023
680 (in isoform 3)Ubiquitination-60.0722790023
684S-nitrosocysteineKGFKATDCVGHDVAT
CCCCCCCCCCHHHHH		3.25-
684S-nitrosylationKGFKATDCVGHDVAT
CCCCCCCCCCHHHHH		3.2521278135
691PhosphorylationCVGHDVATLLRDAVK
CCCHHHHHHHHHHHH		26.6129899451
763 (in isoform 3)Ubiquitination-2.02-
777 (in isoform 3)Ubiquitination-5.22-
792PhosphorylationVDEYSLNSGKQRFEK
HHHHCCCCCHHHHHH		53.3029899451
819AcetylationNILIDFTKKGFLFRG
HHHHHHHCCCEEECE		51.397969715
819UbiquitinationNILIDFTKKGFLFRG
HHHHHHHCCCEEECE		51.3922790023
819 (in isoform 3)Ubiquitination-51.3922790023
828 (in isoform 3)Ubiquitination-5.84-
833UbiquitinationGQISEPLKTRGIFET
EECCCCCCCCCCEEH		47.0622790023
833 (in isoform 3)Ubiquitination-47.0622790023
844PhosphorylationIFETKFLSQIESDRL
CEEHHHHHHHHHHHH		32.0429899451
844 (in isoform 3)Ubiquitination-32.04-
848PhosphorylationKFLSQIESDRLALLQ
HHHHHHHHHHHHHHH		29.6522817900
869S-nitrosocysteineQLGLNSTCDDSILVK
HCCCCCCCCCHHHHH		5.70-
869S-nitrosylationQLGLNSTCDDSILVK
HCCCCCCCCCHHHHH		5.7021278135
877PhosphorylationDDSILVKTVCGVVSK
CCHHHHHHHHHHHCH		17.3529899451
879S-nitrosocysteineSILVKTVCGVVSKRA
HHHHHHHHHHHCHHH		4.08-
879GlutathionylationSILVKTVCGVVSKRA
HHHHHHHHHHHCHHH		4.0824333276
879S-nitrosylationSILVKTVCGVVSKRA
HHHHHHHHHHHCHHH		4.0821278135
884AcetylationTVCGVVSKRAAQLCG
HHHHHHCHHHHHHHC		34.1519842907
884UbiquitinationTVCGVVSKRAAQLCG
HHHHHHCHHHHHHHC		34.1522790023
884 (in isoform 3)Ubiquitination-34.1522790023
885 (in isoform 3)Ubiquitination-27.87-
890S-nitrosocysteineSKRAAQLCGAGMAAV
CHHHHHHHCCCHHHH		2.03-
890S-nitrosylationSKRAAQLCGAGMAAV
CHHHHHHHCCCHHHH		2.0321278135
900AcetylationGMAAVVEKIRENRGL
CHHHHHHHHHHCCCC		35.146567363
900UbiquitinationGMAAVVEKIRENRGL
CHHHHHHHHHHCCCC		35.1422790023
900 (in isoform 3)Ubiquitination-35.1422790023
913PhosphorylationGLDHLNVTVGVDGTL
CCCCEEEEECCCCCE		15.52-
936AcetylationRIMHQTVKELSPKCT
HHHHHHHHHHCCCCE		57.2222733758
941UbiquitinationTVKELSPKCTVSFLL
HHHHHCCCCEEEEEE		38.8822790023
941 (in isoform 3)Ubiquitination-38.8822790023
942S-nitrosocysteineVKELSPKCTVSFLLS
HHHHCCCCEEEEEEC		5.29-
942S-nitrosylationVKELSPKCTVSFLLS
HHHHCCCCEEEEEEC		5.2924895380
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HXK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HXK1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXK1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-83, AND MASSSPECTROMETRY.

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