PSA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA2_MOUSE
• UniProt AC: P49722
• Protein Name: Proteasome subunit alpha type-2
• Gene Name: Psma2
• Organism: Mus musculus (Mouse).
• Sequence Length: 234
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAERGYSFS ------CCCCCCEEE	15.39	16857966
6	Phosphorylation	--MAERGYSFSLTTF --CCCCCCEEEEEEE	15.58	25521595
7	Phosphorylation	-MAERGYSFSLTTFS -CCCCCCEEEEEEEC	15.93	25521595
9	Phosphorylation	AERGYSFSLTTFSPS CCCCCEEEEEEECCC	20.90	26745281
11	Phosphorylation	RGYSFSLTTFSPSGK CCCEEEEEEECCCCC	25.29	26745281
12	Phosphorylation	GYSFSLTTFSPSGKL CCEEEEEEECCCCCE	27.66	26745281
14	Phosphorylation	SFSLTTFSPSGKLVQ EEEEEEECCCCCEEE	18.96	26239621
16	Phosphorylation	SLTTFSPSGKLVQIE EEEEECCCCCEEEEH	47.57	26745281
24	Phosphorylation	GKLVQIEYALAAVAG CCEEEEHHHHHHHHC	14.45	-
50	Ubiquitination	GVVLATEKKQKSILY CEEEEECCCCCCCCC	57.03	-
53	Ubiquitination	LATEKKQKSILYDER EEECCCCCCCCCCCC	48.63	-
53	Malonylation	LATEKKQKSILYDER EEECCCCCCCCCCCC	48.63	26320211
57	Phosphorylation	KKQKSILYDERSVHK CCCCCCCCCCCCCCC	17.68	26032504
70	Acetylation	HKVEPITKHIGLVYS CCCCCCHHHEEEEEC	33.66	-
70	Ubiquitination	HKVEPITKHIGLVYS CCCCCCHHHEEEEEC	33.66	27667366
76	Phosphorylation	TKHIGLVYSGMGPDY HHHEEEEECCCCCCH	12.44	25177544
77	Phosphorylation	KHIGLVYSGMGPDYR HHEEEEECCCCCCHH	18.15	17242355
92	Phosphoglycerylation	VLVHRARKLAQQYYL HHHHHHHHHHHHHHE	47.38	-
92	Ubiquitination	VLVHRARKLAQQYYL HHHHHHHHHHHHHHE	47.38	27667366
92	Acetylation	VLVHRARKLAQQYYL HHHHHHHHHHHHHHE	47.38	23806337
92	Malonylation	VLVHRARKLAQQYYL HHHHHHHHHHHHHHE	47.38	26320211
97	Phosphorylation	ARKLAQQYYLVYQEP HHHHHHHHHEEECCC	6.15	-
98	Phosphorylation	RKLAQQYYLVYQEPI HHHHHHHHEEECCCC	5.83	18563927
101	Phosphorylation	AQQYYLVYQEPIPTA HHHHHEEECCCCCHH	12.45	17242355
121	Phosphorylation	VASVMQEYTQSGGVR HHHHHHHHHHCCCCC	8.00	-
165	Ubiquitination	WKATAMGKNYVNGKT EEEEECCCCCCCCEE	31.83	-
167	Phosphorylation	ATAMGKNYVNGKTFL EEECCCCCCCCEEHH	9.97	-
171	Succinylation	GKNYVNGKTFLEKRY CCCCCCCEEHHHHHH	30.79	23954790
171	Acetylation	GKNYVNGKTFLEKRY CCCCCCCEEHHHHHH	30.79	23806337
171	Ubiquitination	GKNYVNGKTFLEKRY CCCCCCCEEHHHHHH	30.79	-
176	Ubiquitination	NGKTFLEKRYNEDLE CCEEHHHHHHCCCCC	63.43	27667366
198	Phosphorylation	AILTLKESFEGQMTE HHHHHHHHHCCCCCC	27.32	18579562

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADRM1_HUMAN	ADRM1	physical	17139257
TBA1A_HUMAN	TUBA1A	physical	17139257
HSP74_HUMAN	HSPA4	physical	17139257
HSP7C_HUMAN	HSPA8	physical	17139257
GRP78_HUMAN	HSPA5	physical	17139257

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-76, AND MASSSPECTROMETRY.
PubMed: 18034455