PTN13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN13_MOUSE
• UniProt AC: Q64512
• Protein Name: Tyrosine-protein phosphatase non-receptor type 13
• Gene Name: Ptpn13
• Organism: Mus musculus (Mouse).
• Sequence Length: 2453
• Subcellular Localization: Cytoplasm, cytoskeleton . Nucleus . Cell projection, lamellipodium . Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover.
• Protein Description: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2..
• Protein Sequence: MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVSNQDLRASTAPEVLQSHSLTSLADVEKIHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSNVKQLVKLVLGNISGTDPLSRSSEQKPDRSQAIRDRLRGKGLPTGRSSTSDALDTHEAPLSQQTFVNKGLSKSMGFLSIRDTRDEEDYLKDTPSDNNSRHEDSETFSSPYQFKTSTPQMDALSKKKTWASSMDLLCAANRDISGETGRYQRCDPKTVTGRTSITPRKKEGRYSDGSIALDIFGPQKVEPVIHTRELPTSTAVSSALDRIRERQQKLQVLREAMNVEEPVRRYKTYHSDIFSISSESPSVISSESDFRQVRKSEASKRFESSSGLPGVDETGQTRPSRQYETSLEGNLINQDIMLRRQEEEMMQLQARMALRQSRLSLYPGDTVKASMLDISRDPLREMALETAMTQRKLRNFFGPEFVKMTVEPFVSLDLPRSILSQTKKGKSEDQRRKVNIRLLSGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATRKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHDLTCHQYYLQLRKDLLDERVHCDDEAALLLASLALQAEYGDYQPEVHGVSYFRLEHYLPARVMEKLDVSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLHLCSSQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTINKLAVRPLSVQAEILKRLSSSEWSLYQPLQNSSKEKTDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMEALPQAFAELVGKPLYPMARSDTESLAGLPKLDNSKSVASLNRSPERRNHESDSSTEDPGQAYVVGMSLPSSGKSSSQVPFKDNDTLHKRWSIVSSPEREITLVNLKKDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPSKVPSTPVHFANGMKSYTKKPAYMQDSAMDPSEDQPWPRGTLRHIPESPFGLSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDRGWQEPQHSSPSPSVTTKVNEKTFSDSNRSKAKRRGISDLIEHLDCADSDKDDSTYTSSQDHQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAIIPKGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQVPTSRERDPAGPQSPPPDQDAQRQAPEKVAKQTPHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLIPEQINGSIVRVKKLFPGQPAAESGKIDVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQPSSSVEQGASSDDNGVSGKTKNHCRAPSRRESYSDHSESGEDDSVRAPAKMPNVTRVAAFPHEAPRSQEESICAMFYLPRKIPGKLESESSHPPPLDVSPGQTCQPPAECAPSDATGKHFTHLASQLSKEENITTLKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRAAPKTVRLVLGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAVDGSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVPTTRAAISAPRFTKANGLTSMEPSGQPALMPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYDDPQEAEVIQSLLDVVDEEAQNLLNQRHATRRACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPESVSSGEGKVDLASLTAASQEEKPIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFIVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVILYVLTHLQAEEQKAQQPGLPQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
181	Phosphorylation	KLVLGNISGTDPLSR HHHHCCCCCCCCCCC	39.37	26239621
183	Phosphorylation	VLGNISGTDPLSRSS HHCCCCCCCCCCCCC	27.87	28066266
187	Phosphorylation	ISGTDPLSRSSEQKP CCCCCCCCCCCCCCC	35.19	28066266
215	Phosphorylation	GLPTGRSSTSDALDT CCCCCCCCCCCCCCC	30.48	21659604
240	Phosphorylation	VNKGLSKSMGFLSIR HCHHHCCCCCEEEEC	22.29	25521595
245	Phosphorylation	SKSMGFLSIRDTRDE CCCCCEEEECCCCCH	17.20	24759943
261	Phosphorylation	DYLKDTPSDNNSRHE HHHCCCCCCCCCCCC	55.87	23375375
265	Phosphorylation	DTPSDNNSRHEDSET CCCCCCCCCCCCCCC	41.07	23375375
270	Phosphorylation	NNSRHEDSETFSSPY CCCCCCCCCCCCCCC	35.24	23375375
272	Phosphorylation	SRHEDSETFSSPYQF CCCCCCCCCCCCCCC	32.54	23375375
281	Phosphorylation	SSPYQFKTSTPQMDA CCCCCCCCCCCCHHH	38.84	24759943
282	Phosphorylation	SPYQFKTSTPQMDAL CCCCCCCCCCCHHHH	38.39	21183079
283	Phosphorylation	PYQFKTSTPQMDALS CCCCCCCCCCHHHHH	23.83	28973931
294	Phosphorylation	DALSKKKTWASSMDL HHHHCCCHHHHHHHH	34.83	29233185
297	Phosphorylation	SKKKTWASSMDLLCA HCCCHHHHHHHHHHH	20.11	26239621
298	Phosphorylation	KKKTWASSMDLLCAA CCCHHHHHHHHHHHH	14.47	26239621
339	Phosphorylation	PRKKEGRYSDGSIAL CCCCCCCCCCCCEEE	23.21	28066266
340	Phosphorylation	RKKEGRYSDGSIALD CCCCCCCCCCCEEEE	33.85	26239621
343	Phosphorylation	EGRYSDGSIALDIFG CCCCCCCCEEEECCC	15.07	26239621
411	Phosphorylation	SDIFSISSESPSVIS CCCEECCCCCCCCCC	40.19	23375375
413	Phosphorylation	IFSISSESPSVISSE CEECCCCCCCCCCCH	25.15	23375375
415	Phosphorylation	SISSESPSVISSESD ECCCCCCCCCCCHHH	41.17	26239621
418	Phosphorylation	SESPSVISSESDFRQ CCCCCCCCCHHHHHH	26.37	23375375
419	Phosphorylation	ESPSVISSESDFRQV CCCCCCCCHHHHHHH	29.96	23375375
490	Phosphorylation	ARMALRQSRLSLYPG HHHHHHHHCHHCCCC	28.84	26239621
493	Phosphorylation	ALRQSRLSLYPGDTV HHHHHCHHCCCCCCC	25.42	26239621
495	Phosphorylation	RQSRLSLYPGDTVKA HHHCHHCCCCCCCCH	11.20	28066266
499	Phosphorylation	LSLYPGDTVKASMLD HHCCCCCCCCHHHHC	29.80	29514104
503	Phosphorylation	PGDTVKASMLDISRD CCCCCCHHHHCCCCC	17.73	28059163
734	Phosphorylation	VMEKLDVSYIKEELP HHHHCCHHHHHHHHH	22.32	24719451
735	Phosphorylation	MEKLDVSYIKEELPK HHHCCHHHHHHHHHH	18.83	24719451
880	Phosphorylation	AQDIERASFRSLNLQ HHHHHHHHHHHCCCC	27.67	29514104
883	Phosphorylation	IERASFRSLNLQAES HHHHHHHHCCCCCEE	21.43	27180971
890	Phosphorylation	SLNLQAESVRGFNMG HCCCCCEECCCCCCC	21.82	19060867
901	Phosphorylation	FNMGRAISTGSLASS CCCCCCHHCCCCCHH	26.23	27087446
902	Phosphorylation	NMGRAISTGSLASST CCCCCHHCCCCCHHH	25.36	26239621
904	Phosphorylation	GRAISTGSLASSTIN CCCHHCCCCCHHHHH	22.35	22942356
907	Phosphorylation	ISTGSLASSTINKLA HHCCCCCHHHHHHHC	33.05	19060867
908	Phosphorylation	STGSLASSTINKLAV HCCCCCHHHHHHHCC	27.92	19060867
909	Phosphorylation	TGSLASSTINKLAVR CCCCCHHHHHHHCCC	26.52	27087446
919	Phosphorylation	KLAVRPLSVQAEILK HHCCCCHHHHHHHHH	18.18	26239621
929	Phosphorylation	AEILKRLSSSEWSLY HHHHHHHCCCCCCHH	35.53	26239621
930	Phosphorylation	EILKRLSSSEWSLYQ HHHHHHCCCCCCHHH	36.55	26239621
931	Phosphorylation	ILKRLSSSEWSLYQP HHHHHCCCCCCHHHC	39.44	26239621
934	Phosphorylation	RLSSSEWSLYQPLQN HHCCCCCCHHHCCCC	17.10	27087446
936	Phosphorylation	SSSEWSLYQPLQNSS CCCCCCHHHCCCCCC	11.54	26239621
947	Phosphorylation	QNSSKEKTDKASWEE CCCCCCCCCCCCHHC	43.77	20495213
951	Phosphorylation	KEKTDKASWEEKPRG CCCCCCCCHHCCCCC	40.54	28507225
960	Phosphorylation	EEKPRGMSKSYHDLS HCCCCCCCCCHHCHH	22.67	28507225
962	Phosphorylation	KPRGMSKSYHDLSQA CCCCCCCCHHCHHHH	22.01	28507225
963	Phosphorylation	PRGMSKSYHDLSQAS CCCCCCCHHCHHHHH	11.77	29514104
967	Phosphorylation	SKSYHDLSQASLCPH CCCHHCHHHHHCCCC	29.74	29233185
1002	Phosphorylation	PLYPMARSDTESLAG CCCCCCCCCCHHHCC	39.07	21659605
1004	Phosphorylation	YPMARSDTESLAGLP CCCCCCCCHHHCCCC	28.81	28066266
1006	Phosphorylation	MARSDTESLAGLPKL CCCCCCHHHCCCCCC	26.13	28066266
1017	Ubiquitination	LPKLDNSKSVASLNR CCCCCCCCCHHHCCC	56.03	-
1018	Phosphorylation	PKLDNSKSVASLNRS CCCCCCCCHHHCCCC	23.80	27087446
1021	Phosphorylation	DNSKSVASLNRSPER CCCCCHHHCCCCHHH	24.83	27087446
1025	Phosphorylation	SVASLNRSPERRNHE CHHHCCCCHHHCCCC	30.00	26239621
1073	Phosphorylation	DTLHKRWSIVSSPER CCCHHHEEECCCCCC	19.69	27087446
1076	Phosphorylation	HKRWSIVSSPEREIT HHHEEECCCCCCEEE	38.21	21659605
1077	Phosphorylation	KRWSIVSSPEREITL HHEEECCCCCCEEEE	21.64	28066266
1221	Phosphorylation	TLRHIPESPFGLSGG CCCCCCCCCCCCCCC	21.85	26239621
1247	Phosphorylation	RTESASLSQSQVNGF CCCCCCCCHHHHHHH	25.87	21082442
1270	Phosphorylation	GWQEPQHSSPSPSVT CCCCCCCCCCCCCCE	38.40	26239621
1271	Phosphorylation	WQEPQHSSPSPSVTT CCCCCCCCCCCCCEE	27.54	26239621
1273	Phosphorylation	EPQHSSPSPSVTTKV CCCCCCCCCCCEEEE	31.58	26239621
1275	Phosphorylation	QHSSPSPSVTTKVNE CCCCCCCCCEEEECC	36.11	28066266
1277	Phosphorylation	SSPSPSVTTKVNEKT CCCCCCCEEEECCCC	25.82	28066266
1278	Phosphorylation	SPSPSVTTKVNEKTF CCCCCCEEEECCCCC	30.73	28066266
1284	Phosphorylation	TTKVNEKTFSDSNRS EEEECCCCCCCCCHH	23.38	27087446
1286	Phosphorylation	KVNEKTFSDSNRSKA EECCCCCCCCCHHHH	45.41	23375375
1288	Phosphorylation	NEKTFSDSNRSKAKR CCCCCCCCCHHHHHH	32.70	29514104
1291	Phosphorylation	TFSDSNRSKAKRRGI CCCCCCHHHHHHCCH	41.01	29514104
1310	Phosphorylation	EHLDCADSDKDDSTY HHHCCCCCCCCCCCC	28.21	26160508
1315	Phosphorylation	ADSDKDDSTYTSSQD CCCCCCCCCCCCCCC	33.19	26160508
1316	Phosphorylation	DSDKDDSTYTSSQDH CCCCCCCCCCCCCCC	37.50	26160508
1317	Phosphorylation	SDKDDSTYTSSQDHQ CCCCCCCCCCCCCCC	14.47	26160508
1318	Phosphorylation	DKDDSTYTSSQDHQT CCCCCCCCCCCCCCC	23.22	26160508
1319	Phosphorylation	KDDSTYTSSQDHQTS CCCCCCCCCCCCCCC	18.65	26160508
1320	Phosphorylation	DDSTYTSSQDHQTSK CCCCCCCCCCCCCCC	31.65	26160508
1340	Phosphorylation	SLSTSNKTSFPTSSA CCCCCCCCCCCCCCC	39.59	26239621
1341	Phosphorylation	LSTSNKTSFPTSSAS CCCCCCCCCCCCCCC	30.73	26239621
1348	Phosphorylation	SFPTSSASPPKPGDT CCCCCCCCCCCCCCE	43.62	26239621
1456	Phosphorylation	RDPAGPQSPPPDQDA CCCCCCCCCCCCHHH	42.37	20139300
1499	Phosphorylation	VKLFKNSSGLGFSFS EEEEECCCCCCCCCC	47.64	28973931
1504	Phosphorylation	NSSGLGFSFSREDNL CCCCCCCCCCCCCCC	22.10	19060867
1506	Phosphorylation	SGLGFSFSREDNLIP CCCCCCCCCCCCCCH	33.30	21183079
1595	Phosphorylation	TTFLNPLYSPANSFL CCCCCCCCCHHHHHH	17.54	26239621
1596	Phosphorylation	TFLNPLYSPANSFLN CCCCCCCCHHHHHHH	25.81	26239621
1612	Phosphorylation	SKETSQPSSSVEQGA CCCCCCCCCCCCCCC	27.84	23375375
1620	Phosphorylation	SSVEQGASSDDNGVS CCCCCCCCCCCCCCC	40.92	23375375
1621	Phosphorylation	SVEQGASSDDNGVSG CCCCCCCCCCCCCCC	48.74	23375375
1642	Phosphorylation	RAPSRRESYSDHSES CCCCCCCCCCCCCCC	28.29	21183079
1643	Phosphorylation	APSRRESYSDHSESG CCCCCCCCCCCCCCC	17.23	21183079
1644	Phosphorylation	PSRRESYSDHSESGE CCCCCCCCCCCCCCC	37.82	21183079
1647	Phosphorylation	RESYSDHSESGEDDS CCCCCCCCCCCCCCC	38.15	21183079
1649	Phosphorylation	SYSDHSESGEDDSVR CCCCCCCCCCCCCCC	50.96	21183079
1709	Phosphorylation	HPPPLDVSPGQTCQP CCCCCCCCCCCCCCC	23.99	28973931
1735	Phosphorylation	KHFTHLASQLSKEEN CHHHHHHHHCCHHCC	37.71	26239621
1738	Phosphorylation	THLASQLSKEENITT HHHHHHCCHHCCHHH	30.31	26239621
1816	Phosphorylation	RLIKVNDTDVTNMTH EEEEECCCCCCCCCH	27.45	29899451
1824	Phosphorylation	DVTNMTHTDAVNLLR CCCCCCHHHHHHHHH	19.25	29899451
1954	Phosphorylation	PTTRAAISAPRFTKA CCCCHHHCCCCCCCC	27.74	24453211
2059	Phosphorylation	HATRRACSPDPLRTN HHHHCCCCCCCCCCC	31.21	20139300
2106	Phosphorylation	LASLTAASQEEKPIE HHHHHHCCCCCCCCC	35.34	28973931
2123	Phosphorylation	ATQESRNSTTETTDG CCHHHHCCCCCCCCC	35.28	28973931
2210	Phosphorylation	ENRRKNRYKNILPYD HHHHHHCCCCCCCCC	20.13	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1073	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
1077	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN13_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRD7_MOUSE	Brd7	physical	10526152
PDE4D_HUMAN	PDE4D	physical	26496610
TTC1_HUMAN	TTC1	physical	26496610
VINC_HUMAN	VCL	physical	26496610
GPAA1_HUMAN	GPAA1	physical	26496610
FND3A_HUMAN	FNDC3A	physical	26496610
SUCO_HUMAN	SUCO	physical	26496610
CHPF2_HUMAN	CHPF2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND MASSSPECTROMETRY.
PubMed: 19367708