| UniProt ID | SUCO_HUMAN | |
|---|---|---|
| UniProt AC | Q9UBS9 | |
| Protein Name | SUN domain-containing ossification factor | |
| Gene Name | SUCO | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1254 | |
| Subcellular Localization |
Rough endoplasmic reticulum membrane Single-pass type I membrane protein. |
|
| Protein Description | Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).. | |
| Protein Sequence | MKKHRRALALVSCLFLCSLVWLPSWRVCCKESSSASASSYYSQDDNCALENEDVQFQKKDEREGPINAESLGKSGSNLPISPKEHKLKDDSIVDVQNTESKKLSPPVVETLPTVDLHEESSNAVVDSETVENISSSSTSEITPISKLDEIEKSGTIPIAKPSETEQSETDCDVGEALDASAPIEQPSFVSPPDSLVGQHIENVSSSHGKGKITKSEFESKVSASEQGGGDPKSALNASDNLKNESSDYTKPGDIDPTSVASPKDPEDIPTFDEWKKKVMEVEKEKSQSMHASSNGGSHATKKVQKNRNNYASVECGAKILAANPEAKSTSAILIENMDLYMLNPCSTKIWFVIELCEPIQVKQLDIANYELFSSTPKDFLVSISDRYPTNKWIKLGTFHGRDERNVQSFPLDEQMYAKYVKMFIKYIKVELLSHFGSEHFCPLSLIRVFGTSMVEEYEEIADSQYHSERQELFDEDYDYPLDYNTGEDKSSKNLLGSATNAILNMVNIAANILGAKTEDLTEGNKSISENATATAAPKMPESTPVSTPVPSPEYVTTEVHTHDMEPSTPDTPKESPIVQLVQEEEEEASPSTVTLLGSGEQEDESSPWFESETQIFCSELTTICCISSFSEYIYKWCSVRVALYRQRSRTALSKGKDYLVLAQPPLLLPAESVDVSVLQPLSGELENTNIEREAETVVLGDLSSSMHQDDLVNHTVDAVELEPSHSQTLSQSLLLDITPEINPLPKIEVSESVEYEAGHIPSPVIPQESSVEIDNETEQKSESFSSIEKPSITYETNKVNELMDNIIKEDVNSMQIFTKLSETIVPPINTATVPDNEDGEAKMNIADTAKQTLISVVDSSSLPEVKEEEQSPEDALLRGLQRTATDFYAELQNSTDLGYANGNLVHGSNQKESVFMRLNNRIKALEVNMSLSGRYLEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQSYLVISLVLCVVLGLMLCMQRCRNTSQFDGDYISKLPKSNQYPSPKRCFSSYDDMNLKRRTSFPLMRSKSLQLTGKEVDPNDLYIVEPLKFSPEKKKKRCKYKIEKIETIKPEEPLHPIANGDIKGRKPFTNQRDFSNMGEVYHSSYKGPPSEGSSETSSQSEESYFCGISACTSLCNGQSQKTKTEKRALKRRRSKVQDQGKLIKTLIQTKSGSLPSLHDIIKGNKEITVGTFGVTAVSGHI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | CSLVWLPSWRVCCKE HHHHHCCCCHHEECC | 26091039 | ||
| 75 (in isoform 2) | Phosphorylation | - | 24400094 | ||
| 78 (in isoform 2) | Phosphorylation | - | 24400094 | ||
| 101 | Acetylation | DVQNTESKKLSPPVV ECCCCCCCCCCCCCC | 7395855 | ||
| 142 | Phosphorylation | SSSTSEITPISKLDE CCCCCCCCCCHHHHH | - | ||
| 145 | Phosphorylation | TSEITPISKLDEIEK CCCCCCCHHHHHHHH | - | ||
| 149 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 153 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 202 | N-linked_Glycosylation | LVGQHIENVSSSHGK HCHHHHHHCHHCCCC | UniProtKB CARBOHYD | ||
| 233 | Phosphorylation | QGGGDPKSALNASDN CCCCCHHHHCCCCHH | 28674151 | ||
| 236 | N-linked_Glycosylation | GDPKSALNASDNLKN CCHHHHCCCCHHCCC | UniProtKB CARBOHYD | ||
| 258 | Phosphorylation | PGDIDPTSVASPKDP CCCCCCCCCCCCCCH | 28674151 | ||
| 261 | Phosphorylation | IDPTSVASPKDPEDI CCCCCCCCCCCHHHC | 28674151 | ||
| 340 | Phosphorylation | LIENMDLYMLNPCST EEECCEEEEECCCCC | 26074081 | ||
| 346 | Phosphorylation | LYMLNPCSTKIWFVI EEEECCCCCEEEEEE | 26074081 | ||
| 347 | Phosphorylation | YMLNPCSTKIWFVIE EEECCCCCEEEEEEC | 26074081 | ||
| 408 | Phosphorylation | RDERNVQSFPLDEQM CCCCCCCCCCCCHHH | 29978859 | ||
| 433 | Phosphorylation | YIKVELLSHFGSEHF HHHHHHHHHCCCCCC | 22210691 | ||
| 444 | Phosphorylation | SEHFCPLSLIRVFGT CCCCCCHHHHHHHCC | 22210691 | ||
| 524 | N-linked_Glycosylation | TEDLTEGNKSISENA HHHCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 556 | O-linked_Glycosylation | VPSPEYVTTEVHTHD CCCCCCEEEEEECCC | OGP | ||
| 738 | O-linked_Glycosylation | QSLLLDITPEINPLP HHHHCCCCCCCCCCC | OGP | ||
| 808 | Acetylation | ELMDNIIKEDVNSMQ HHHHHHHHHCHHHHH | 19813627 | ||
| 883 | Phosphorylation | LLRGLQRTATDFYAE HHHHHHHHHHHHHHH | 26074081 | ||
| 885 | Phosphorylation | RGLQRTATDFYAELQ HHHHHHHHHHHHHHH | 26074081 | ||
| 888 | Phosphorylation | QRTATDFYAELQNST HHHHHHHHHHHHCCC | 26074081 | ||
| 928 | N-linked_Glycosylation | RIKALEVNMSLSGRY HHHEEEEECHHCHHH | UniProtKB CARBOHYD | ||
| 955 | N-linked_Glycosylation | EEMQKAFNKTIVKLQ HHHHHHHHHHHHHHH | UniProtKB CARBOHYD | ||
| 964 | Phosphorylation | TIVKLQNTSRIAEEQ HHHHHHHHHHHHHHH | 29978859 | ||
| 965 | Phosphorylation | IVKLQNTSRIAEEQD HHHHHHHHHHHHHHH | 29978859 | ||
| 1055 | Phosphorylation | PKSNQYPSPKRCFSS CCCCCCCCCCCCCCC | 25159151 | ||
| 1061 | Phosphorylation | PSPKRCFSSYDDMNL CCCCCCCCCCCCCCC | 29978859 | ||
| 1062 | Phosphorylation | SPKRCFSSYDDMNLK CCCCCCCCCCCCCCH | 29978859 | ||
| 1072 | Phosphorylation | DMNLKRRTSFPLMRS CCCCHHHCCCHHHCC | 30266825 | ||
| 1073 | Phosphorylation | MNLKRRTSFPLMRSK CCCHHHCCCHHHCCC | 30266825 | ||
| 1079 | Phosphorylation | TSFPLMRSKSLQLTG CCCHHHCCCCEECCC | 28176443 | ||
| 1081 | Phosphorylation | FPLMRSKSLQLTGKE CHHHCCCCEECCCCC | 23401153 | ||
| 1085 | Phosphorylation | RSKSLQLTGKEVDPN CCCCEECCCCCCCCC | 30266825 | ||
| 1095 | Phosphorylation | EVDPNDLYIVEPLKF CCCCCCCEEECCCCC | 27732954 | ||
| 1103 | Phosphorylation | IVEPLKFSPEKKKKR EECCCCCCHHHHHCC | 30266825 | ||
| 1170 | Phosphorylation | SEGSSETSSQSEESY CCCCCCCCCCCCHHC | 30576142 | ||
| 1173 | Phosphorylation | SSETSSQSEESYFCG CCCCCCCCCHHCCCC | 30576142 | ||
| 1176 | Phosphorylation | TSSQSEESYFCGISA CCCCCCHHCCCCHHH | 30576142 | ||
| 1182 | Phosphorylation | ESYFCGISACTSLCN HHCCCCHHHHHHHHC | 18669648 | ||
| 1222 | Phosphorylation | LIKTLIQTKSGSLPS HHHHHHHHCCCCCCC | - | ||
| 1224 | Phosphorylation | KTLIQTKSGSLPSLH HHHHHHCCCCCCCHH | 30266825 | ||
| 1226 | Phosphorylation | LIQTKSGSLPSLHDI HHHHCCCCCCCHHHH | 30266825 | ||
| 1229 | Phosphorylation | TKSGSLPSLHDIIKG HCCCCCCCHHHHHCC | 30266825 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SUCO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUCO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUCO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CALU_HUMAN | CALU | physical | 26496610 | |
| TNPO1_HUMAN | TNPO1 | physical | 26496610 | |
| PDIA1_HUMAN | P4HB | physical | 26496610 | |
| PPCE_HUMAN | PREP | physical | 26496610 | |
| PSD11_HUMAN | PSMD11 | physical | 26496610 | |
| RL10_HUMAN | RPL10 | physical | 26496610 | |
| PHLA2_HUMAN | PHLDA2 | physical | 26496610 | |
| MED24_HUMAN | MED24 | physical | 26496610 | |
| NIPBL_HUMAN | NIPBL | physical | 26496610 | |
| NDUBB_HUMAN | NDUFB11 | physical | 26496610 | |
| S35F6_HUMAN | SLC35F6 | physical | 26496610 | |
| ELOV5_HUMAN | ELOVL5 | physical | 26496610 | |
| GMCL1_HUMAN | GMCL1 | physical | 26496610 | |
| I20L2_HUMAN | ISG20L2 | physical | 26496610 | |
| BAP18_HUMAN | C17orf49 | physical | 26496610 | |
| TAPT1_HUMAN | TAPT1 | physical | 26496610 | |
| LAMA1_HUMAN | LAMA1 | physical | 26496610 | |
| TIM23_HUMAN | TIMM23 | physical | 26496610 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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