I20L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I20L2_HUMAN
• UniProt AC: Q9H9L3
• Protein Name: Interferon-stimulated 20 kDa exonuclease-like 2
• Gene Name: ISG20L2
• Organism: Homo sapiens (Human).
• Sequence Length: 353
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group..
• Protein Sequence: MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSKKGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLGEFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNSTQAHSENKCSGASQKLPRKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLARNPPTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Acetylation	AKHRNFVKKRRLLER HHHCCHHHHHHHHHH	36.10	30589553
31	Acetylation	KHRNFVKKRRLLERR HHCCHHHHHHHHHHH	37.13	30589559
64	Phosphorylation	EPSKKGETPTVDGTW CCCCCCCCCCCCCCC	32.69	28555341
66	Phosphorylation	SKKGETPTVDGTWKT CCCCCCCCCCCCCCC	38.35	24626860
73	Phosphorylation	TVDGTWKTPSFPKKK CCCCCCCCCCCCCCC	18.74	28111955
75	Phosphorylation	DGTWKTPSFPKKKTA CCCCCCCCCCCCCCC	60.45	24626860
81	Phosphorylation	PSFPKKKTAASSNGS CCCCCCCCCCCCCCC	36.01	-
95	Sumoylation	SGQPLDKKAAVSWLT CCCCCCHHHHHHCCC	41.04	-
95	Sumoylation	SGQPLDKKAAVSWLT CCCCCCHHHHHHCCC	41.04	-
99	Phosphorylation	LDKKAAVSWLTPAPS CCHHHHHHCCCCCCC	16.19	-
102	Phosphorylation	KAAVSWLTPAPSKKA HHHHHCCCCCCCCCC	15.90	28555341
107	Acetylation	WLTPAPSKKADSVAA CCCCCCCCCCCHHHH	51.42	25953088
131	Phosphorylation	SALPKINSHPTRSQK HHCHHHHCCCCHHHH	34.03	29052541
134	Phosphorylation	PKINSHPTRSQKKSS HHHHCCCCHHHHHHH	37.21	29052541
136	Phosphorylation	INSHPTRSQKKSSQK HHCCCCHHHHHHHCC	49.16	29052541
189	Phosphorylation	IDCEMVGTGPKGHVS EECEEECCCCCCCHH	38.61	22985185
252	Acetylation	IARGQILKILTGKIV EHHHHHHHHHCCCEE	36.98	26051181
269	Acetylation	HAIHNDFKALQYFHP EHHHCCHHHHHHHCC	51.56	26051181
300	Phosphorylation	ADCPENATMSLKHLT CCCCCCHHHCHHHHH	20.90	29978859
302	Phosphorylation	CPENATMSLKHLTKK CCCCHHHCHHHHHHH	29.88	29978859
307	Phosphorylation	TMSLKHLTKKLLNRD HHCHHHHHHHHHCCC	26.33	29978859
320	Phosphorylation	RDIQVGKSGHSSVED CCCCCCCCCCCCHHH	35.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I20L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I20L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I20L2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of I20L2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.