GPAA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPAA1_HUMAN
• UniProt AC: O43292
• Protein Name: Glycosylphosphatidylinositol anchor attachment 1 protein
• Gene Name: GPAA1
• Organism: Homo sapiens (Human).
• Sequence Length: 621
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate..
• Protein Sequence: MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGLLSDPVRRRA ---CCCCCHHHHHHH	44.93	20071362
51 (in isoform 2)	Ubiquitination	-	19.79	21890473
82	Ubiquitination	RDFAAHRKKSGALPV HHHHHHHHHCCCCCH	41.23	22817900
83	Ubiquitination	DFAAHRKKSGALPVA HHHHHHHHCCCCCHH	54.82	22817900
83 (in isoform 1)	Ubiquitination	-	54.82	21890473
84	Phosphorylation	FAAHRKKSGALPVAW HHHHHHHCCCCCHHH	32.12	22210691
107	Phosphorylation	GLEVYTQSFSRKLPF CCEEEECCCCCCCCC	19.86	17081983
109	Phosphorylation	EVYTQSFSRKLPFPD EEEECCCCCCCCCCC	33.48	24719451
111	Ubiquitination	YTQSFSRKLPFPDET EECCCCCCCCCCCCC	60.35	21906983
111 (in isoform 1)	Ubiquitination	-	60.35	21890473
203	N-linked_Glycosylation	LEAYHDVNVTGMQSS HHHHCCCCCCCCCCC	31.52	UniProtKB CARBOHYD
269 (in isoform 2)	Ubiquitination	-	28.90	21890473
329	Ubiquitination	INSFRQYKYDLVAVG CHHHHCCCCCHHHHH	24.77	23000965
329 (in isoform 1)	Ubiquitination	-	24.77	21890473
330	Phosphorylation	NSFRQYKYDLVAVGK HHHHCCCCCHHHHHH	15.02	-
517	N-linked_Glycosylation	LGCIALTNFSLGFLL HHHHHHHHCCHHHHH	25.92	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPAA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPAA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPAA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3E_HUMAN	EIF3E	physical	16169070
PIN1_HUMAN	PIN1	physical	16169070
GPI8_HUMAN	PIGK	physical	12052837
PIGS_HUMAN	PIGS	physical	12052837
PIGT_HUMAN	PIGT	physical	12052837
PIGT_HUMAN	PIGT	physical	22939629
PIGU_HUMAN	PIGU	physical	22939629
PIGT_HUMAN	PIGT	physical	28514442
TP4A2_HUMAN	PTP4A2	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
STOM_HUMAN	STOM	physical	27173435
SOAT1_HUMAN	SOAT1	physical	27173435
NDUS1_HUMAN	NDUFS1	physical	27173435
ACAP2_HUMAN	ACAP2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.